Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy
Abstract Tumor immune escape presents a significant challenge in cancer treatment, characterized by the upregulation of immune inhibitory molecules and dysfunction of immune cells. Tumor immunotherapy seeks to restore normal anti-tumor immune responses to control and eliminate tumors effectively. Th...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-025-03378-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850154641030905856 |
|---|---|
| author | Hao Zheng Yiquan Chen Wei Luo Shiqi Han Mengjuan Sun Min Lin Chenghan Wu Lili Gao Tian Xie Na Kong |
| author_facet | Hao Zheng Yiquan Chen Wei Luo Shiqi Han Mengjuan Sun Min Lin Chenghan Wu Lili Gao Tian Xie Na Kong |
| author_sort | Hao Zheng |
| collection | DOAJ |
| description | Abstract Tumor immune escape presents a significant challenge in cancer treatment, characterized by the upregulation of immune inhibitory molecules and dysfunction of immune cells. Tumor immunotherapy seeks to restore normal anti-tumor immune responses to control and eliminate tumors effectively. The active ingredients of traditional Chinese medicine (TCM) demonstrate a variety of anti-tumor activities and mechanisms, including the modulation of immune cell functions and inhibiting tumor-related suppressive factors, thereby potentially enhancing anti-tumor immune responses. Furthermore, nano-delivery systems function as efficient carriers to enhance the bioavailability and targeted delivery of TCM active ingredients, augmenting therapeutic efficacy. This review comprehensively analyzes the impact of TCM active ingredients on the immune system and explores the synergistic application of nano-delivery systems in combination with TCM active ingredients for enhancing tumor immunotherapy. Graphical abstract |
| format | Article |
| id | doaj-art-2a64c0e52e5842bd9eb4b1480e780c40 |
| institution | OA Journals |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-2a64c0e52e5842bd9eb4b1480e780c402025-08-20T02:25:16ZengBMCJournal of Nanobiotechnology1477-31552025-05-0123113010.1186/s12951-025-03378-yIntegration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapyHao Zheng0Yiquan Chen1Wei Luo2Shiqi Han3Mengjuan Sun4Min Lin5Chenghan Wu6Lili Gao7Tian Xie8Na Kong9Department of Neurology, The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityLiangzhu Laboratory, Zhejiang University School of MedicineCollege of Pharmacy, Hangzhou Normal UniversityCollege of Pharmacy, Hangzhou Normal UniversityCollege of Pharmacy, Hangzhou Normal UniversityDepartment of Neurology, The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityDepartment of Neurology, The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityDepartment of Neurology, The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityCollege of Pharmacy, Hangzhou Normal UniversityLiangzhu Laboratory, Zhejiang University School of MedicineAbstract Tumor immune escape presents a significant challenge in cancer treatment, characterized by the upregulation of immune inhibitory molecules and dysfunction of immune cells. Tumor immunotherapy seeks to restore normal anti-tumor immune responses to control and eliminate tumors effectively. The active ingredients of traditional Chinese medicine (TCM) demonstrate a variety of anti-tumor activities and mechanisms, including the modulation of immune cell functions and inhibiting tumor-related suppressive factors, thereby potentially enhancing anti-tumor immune responses. Furthermore, nano-delivery systems function as efficient carriers to enhance the bioavailability and targeted delivery of TCM active ingredients, augmenting therapeutic efficacy. This review comprehensively analyzes the impact of TCM active ingredients on the immune system and explores the synergistic application of nano-delivery systems in combination with TCM active ingredients for enhancing tumor immunotherapy. Graphical abstracthttps://doi.org/10.1186/s12951-025-03378-yTumor immunotherapyTCMActive ingredientsDrug deliveryNanocarriers |
| spellingShingle | Hao Zheng Yiquan Chen Wei Luo Shiqi Han Mengjuan Sun Min Lin Chenghan Wu Lili Gao Tian Xie Na Kong Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy Journal of Nanobiotechnology Tumor immunotherapy TCM Active ingredients Drug delivery Nanocarriers |
| title | Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy |
| title_full | Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy |
| title_fullStr | Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy |
| title_full_unstemmed | Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy |
| title_short | Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy |
| title_sort | integration of active ingredients from traditional chinese medicine with nano delivery systems for tumor immunotherapy |
| topic | Tumor immunotherapy TCM Active ingredients Drug delivery Nanocarriers |
| url | https://doi.org/10.1186/s12951-025-03378-y |
| work_keys_str_mv | AT haozheng integrationofactiveingredientsfromtraditionalchinesemedicinewithnanodeliverysystemsfortumorimmunotherapy AT yiquanchen integrationofactiveingredientsfromtraditionalchinesemedicinewithnanodeliverysystemsfortumorimmunotherapy AT weiluo integrationofactiveingredientsfromtraditionalchinesemedicinewithnanodeliverysystemsfortumorimmunotherapy AT shiqihan integrationofactiveingredientsfromtraditionalchinesemedicinewithnanodeliverysystemsfortumorimmunotherapy AT mengjuansun integrationofactiveingredientsfromtraditionalchinesemedicinewithnanodeliverysystemsfortumorimmunotherapy AT minlin integrationofactiveingredientsfromtraditionalchinesemedicinewithnanodeliverysystemsfortumorimmunotherapy AT chenghanwu integrationofactiveingredientsfromtraditionalchinesemedicinewithnanodeliverysystemsfortumorimmunotherapy AT liligao integrationofactiveingredientsfromtraditionalchinesemedicinewithnanodeliverysystemsfortumorimmunotherapy AT tianxie integrationofactiveingredientsfromtraditionalchinesemedicinewithnanodeliverysystemsfortumorimmunotherapy AT nakong integrationofactiveingredientsfromtraditionalchinesemedicinewithnanodeliverysystemsfortumorimmunotherapy |