A Rare Case of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare clinical condition with only about 100 cases reported in the literature. It is characterized by primary hyperplasia of pulmonary neuroendocrine cells (PNECs) which are specialized epithelial cells located throughout the...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2015/318175 |
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| author | Godwin Ofikwu Vishnu R. Mani Ajai Rajabalan Albert Adu Leaque Ahmed Dennis Vega |
| author_facet | Godwin Ofikwu Vishnu R. Mani Ajai Rajabalan Albert Adu Leaque Ahmed Dennis Vega |
| author_sort | Godwin Ofikwu |
| collection | DOAJ |
| description | Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare clinical condition with only about 100 cases reported in the literature. It is characterized by primary hyperplasia of pulmonary neuroendocrine cells (PNECs) which are specialized epithelial cells located throughout the entire respiratory tract, from the trachea to the terminal airways. DIPNECH appears in various forms that include diffuse proliferation of scattered neuroendocrine cells, small nodules, or a linear proliferation. It is usually seen in middle-aged, nonsmoking women with symptoms of cough, dyspnea, and wheezing. We present a 45-year-old, nonsmoking woman who presented with symptoms of DIPNECH associated with bilateral pulmonary nodules and left hilar adenopathy. Of interest, DIPNECH in our patient was associated with metastatic pulmonary carcinoids, papillary carcinoma of the left breast, oncocytoma and angiomyolipoma of her left kidney, and cortical nodules suggestive of tuberous sclerosis. She had video assisted thoracoscopic surgery (VATS), modified radical mastectomy with reconstruction, and radical nephrectomy. She is currently symptom-free most of the time with over two years of follow-up. |
| format | Article |
| id | doaj-art-2a5dd76e2c8e4796be6ffb05120f1fbd |
| institution | OA Journals |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-2a5dd76e2c8e4796be6ffb05120f1fbd2025-08-20T02:04:02ZengWileyCase Reports in Surgery2090-69002090-69192015-01-01201510.1155/2015/318175318175A Rare Case of Diffuse Idiopathic Pulmonary Neuroendocrine Cell HyperplasiaGodwin Ofikwu0Vishnu R. Mani1Ajai Rajabalan2Albert Adu3Leaque Ahmed4Dennis Vega5Department of Surgery, Columbia University College of Physicians and Surgeons at Harlem Hospital, New York, NY 10037, USADepartment of Surgery, New York University School of Medicine, New York, NY 10016, USADepartment of Surgery, Columbia University College of Physicians and Surgeons at Harlem Hospital, New York, NY 10037, USADepartment of Surgery, Columbia University College of Physicians and Surgeons at Harlem Hospital, New York, NY 10037, USADepartment of Surgery, Columbia University College of Physicians and Surgeons at Harlem Hospital, New York, NY 10037, USADepartment of Cardiothoracic Surgery, Harlem Hospital Center, New York, NY 10037, USADiffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare clinical condition with only about 100 cases reported in the literature. It is characterized by primary hyperplasia of pulmonary neuroendocrine cells (PNECs) which are specialized epithelial cells located throughout the entire respiratory tract, from the trachea to the terminal airways. DIPNECH appears in various forms that include diffuse proliferation of scattered neuroendocrine cells, small nodules, or a linear proliferation. It is usually seen in middle-aged, nonsmoking women with symptoms of cough, dyspnea, and wheezing. We present a 45-year-old, nonsmoking woman who presented with symptoms of DIPNECH associated with bilateral pulmonary nodules and left hilar adenopathy. Of interest, DIPNECH in our patient was associated with metastatic pulmonary carcinoids, papillary carcinoma of the left breast, oncocytoma and angiomyolipoma of her left kidney, and cortical nodules suggestive of tuberous sclerosis. She had video assisted thoracoscopic surgery (VATS), modified radical mastectomy with reconstruction, and radical nephrectomy. She is currently symptom-free most of the time with over two years of follow-up.http://dx.doi.org/10.1155/2015/318175 |
| spellingShingle | Godwin Ofikwu Vishnu R. Mani Ajai Rajabalan Albert Adu Leaque Ahmed Dennis Vega A Rare Case of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia Case Reports in Surgery |
| title | A Rare Case of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia |
| title_full | A Rare Case of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia |
| title_fullStr | A Rare Case of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia |
| title_full_unstemmed | A Rare Case of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia |
| title_short | A Rare Case of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia |
| title_sort | rare case of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia |
| url | http://dx.doi.org/10.1155/2015/318175 |
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