Effect of heat-treatment on microstructure of hydroxyapatite porous microspheres for enhanced biocompatibility
Abstract An in-depth exploration into the impact of heat-treatment on the microstructure of HA microspheres is imperative to enhance their biocompatibility, a prerequisite for the development of high-performance HA biomaterials. In this study, the impact of heat-treatment at 600–1000 °C on the micro...
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Journal of Saudi Chemical Society |
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| Online Access: | https://doi.org/10.1007/s44442-025-00010-4 |
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| author | Wei-li Xu Xue-hui Sun Dong Xue Ji-zhao Guo Xin-ke Yan Pei-jian Sun Yi Cao Mei-li Qi Cong Nie |
| author_facet | Wei-li Xu Xue-hui Sun Dong Xue Ji-zhao Guo Xin-ke Yan Pei-jian Sun Yi Cao Mei-li Qi Cong Nie |
| author_sort | Wei-li Xu |
| collection | DOAJ |
| description | Abstract An in-depth exploration into the impact of heat-treatment on the microstructure of HA microspheres is imperative to enhance their biocompatibility, a prerequisite for the development of high-performance HA biomaterials. In this study, the impact of heat-treatment at 600–1000 °C on the microstructure and biocompatibility of HA porous microspheres prepared by the hydrothermal method was investigated. The results showed that the microsheet-assembled HA porous microspheres with diameters of approximately 40–120 μm were obtained. The crystallinity of HA porous microspheres increased with the rise of heat-treatment temperature while the specific surface area and particle size decreased. SEM and TEM observations indicated that the pore size and through porosity of HA microspheres increased under high temperature conditions based on the mechanism of fusion growth of grains. The CCK-8 assay and Live/Dead staining evaluations revealed that heat-treatment promoted the biocompatibility and bioactivity of HA porous microspheres. This study provides new concepts for the controllable optimization of the microstructure and biological properties of HA materials to broaden their clinical applications. |
| format | Article |
| id | doaj-art-2a59ca6cb9914d1ba6370a62d7d300c3 |
| institution | Kabale University |
| issn | 1319-6103 2212-4640 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj-art-2a59ca6cb9914d1ba6370a62d7d300c32025-08-20T04:01:47ZengSpringerJournal of Saudi Chemical Society1319-61032212-46402025-06-012931710.1007/s44442-025-00010-4Effect of heat-treatment on microstructure of hydroxyapatite porous microspheres for enhanced biocompatibilityWei-li Xu0Xue-hui Sun1Dong Xue2Ji-zhao Guo3Xin-ke Yan4Pei-jian Sun5Yi Cao6Mei-li Qi7Cong Nie8Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTCKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTCChina Tobacco Jiangsu Industrial Co., Ltd.Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTCChina Tobacco Jiangsu Industrial Co., Ltd.Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTCChina Tobacco Jiangsu Industrial Co., Ltd.School of Transportation and Civil Engineering, Shandong Jiaotong UniversityKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTCAbstract An in-depth exploration into the impact of heat-treatment on the microstructure of HA microspheres is imperative to enhance their biocompatibility, a prerequisite for the development of high-performance HA biomaterials. In this study, the impact of heat-treatment at 600–1000 °C on the microstructure and biocompatibility of HA porous microspheres prepared by the hydrothermal method was investigated. The results showed that the microsheet-assembled HA porous microspheres with diameters of approximately 40–120 μm were obtained. The crystallinity of HA porous microspheres increased with the rise of heat-treatment temperature while the specific surface area and particle size decreased. SEM and TEM observations indicated that the pore size and through porosity of HA microspheres increased under high temperature conditions based on the mechanism of fusion growth of grains. The CCK-8 assay and Live/Dead staining evaluations revealed that heat-treatment promoted the biocompatibility and bioactivity of HA porous microspheres. This study provides new concepts for the controllable optimization of the microstructure and biological properties of HA materials to broaden their clinical applications.https://doi.org/10.1007/s44442-025-00010-4HydroxyapatiteHeat-treatmentMicrostructureBiocompatibility |
| spellingShingle | Wei-li Xu Xue-hui Sun Dong Xue Ji-zhao Guo Xin-ke Yan Pei-jian Sun Yi Cao Mei-li Qi Cong Nie Effect of heat-treatment on microstructure of hydroxyapatite porous microspheres for enhanced biocompatibility Journal of Saudi Chemical Society Hydroxyapatite Heat-treatment Microstructure Biocompatibility |
| title | Effect of heat-treatment on microstructure of hydroxyapatite porous microspheres for enhanced biocompatibility |
| title_full | Effect of heat-treatment on microstructure of hydroxyapatite porous microspheres for enhanced biocompatibility |
| title_fullStr | Effect of heat-treatment on microstructure of hydroxyapatite porous microspheres for enhanced biocompatibility |
| title_full_unstemmed | Effect of heat-treatment on microstructure of hydroxyapatite porous microspheres for enhanced biocompatibility |
| title_short | Effect of heat-treatment on microstructure of hydroxyapatite porous microspheres for enhanced biocompatibility |
| title_sort | effect of heat treatment on microstructure of hydroxyapatite porous microspheres for enhanced biocompatibility |
| topic | Hydroxyapatite Heat-treatment Microstructure Biocompatibility |
| url | https://doi.org/10.1007/s44442-025-00010-4 |
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