No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects.
Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated pla...
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2014-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0111156 |
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| author | Jens Baumert Jie Huang Barbara McKnight Maria Sabater-Lleal Maristella Steri Audrey Y Chu Stella Trompet Lorna M Lopez Myriam Fornage Alexander Teumer Weihong Tang Alicja R Rudnicka Anders Mälarstig Jouke-Jan Hottenga Maryam Kavousi Jari Lahti Toshiko Tanaka Caroline Hayward Jennifer E Huffman Pierre-Emmanuel Morange Lynda M Rose Saonli Basu Ann Rumley David J Stott Brendan M Buckley Anton J M de Craen Serena Sanna Marco Masala Reiner Biffar Georg Homuth Angela Silveira Bengt Sennblad Anuj Goel Hugh Watkins Martina Müller-Nurasyid Regina Rückerl Kent Taylor Ming-Huei Chen Eco J C de Geus Albert Hofman Jacqueline C M Witteman Moniek P M de Maat Aarno Palotie Gail Davies David S Siscovick Ivana Kolcic Sarah H Wild Jaejoon Song Wendy L McArdle Ian Ford Naveed Sattar David Schlessinger Anne Grotevendt Maria Grazia Franzosi Thomas Illig Melanie Waldenberger Thomas Lumley Geoffrey H Tofler Gonneke Willemsen André G Uitterlinden Fernando Rivadeneira Katri Räikkönen Daniel I Chasman Aaron R Folsom Gordon D Lowe Rudi G J Westendorp P Eline Slagboom Francesco Cucca Henri Wallaschofski Rona J Strawbridge Udo Seedorf Wolfgang Koenig Joshua C Bis Kenneth J Mukamal Jenny van Dongen Elisabeth Widen Oscar H Franco John M Starr Kiang Liu Luigi Ferrucci Ozren Polasek James F Wilson Tiphaine Oudot-Mellakh Harry Campbell Pau Navarro Stefania Bandinelli Johan Eriksson Dorret I Boomsma Abbas Dehghan Robert Clarke Anders Hamsten Eric Boerwinkle J Wouter Jukema Silvia Naitza Paul M Ridker Henry Völzke Ian J Deary Alexander P Reiner David-Alexandre Trégouët Christopher J O'Donnell David P Strachan Annette Peters Nicholas L Smith |
| author_facet | Jens Baumert Jie Huang Barbara McKnight Maria Sabater-Lleal Maristella Steri Audrey Y Chu Stella Trompet Lorna M Lopez Myriam Fornage Alexander Teumer Weihong Tang Alicja R Rudnicka Anders Mälarstig Jouke-Jan Hottenga Maryam Kavousi Jari Lahti Toshiko Tanaka Caroline Hayward Jennifer E Huffman Pierre-Emmanuel Morange Lynda M Rose Saonli Basu Ann Rumley David J Stott Brendan M Buckley Anton J M de Craen Serena Sanna Marco Masala Reiner Biffar Georg Homuth Angela Silveira Bengt Sennblad Anuj Goel Hugh Watkins Martina Müller-Nurasyid Regina Rückerl Kent Taylor Ming-Huei Chen Eco J C de Geus Albert Hofman Jacqueline C M Witteman Moniek P M de Maat Aarno Palotie Gail Davies David S Siscovick Ivana Kolcic Sarah H Wild Jaejoon Song Wendy L McArdle Ian Ford Naveed Sattar David Schlessinger Anne Grotevendt Maria Grazia Franzosi Thomas Illig Melanie Waldenberger Thomas Lumley Geoffrey H Tofler Gonneke Willemsen André G Uitterlinden Fernando Rivadeneira Katri Räikkönen Daniel I Chasman Aaron R Folsom Gordon D Lowe Rudi G J Westendorp P Eline Slagboom Francesco Cucca Henri Wallaschofski Rona J Strawbridge Udo Seedorf Wolfgang Koenig Joshua C Bis Kenneth J Mukamal Jenny van Dongen Elisabeth Widen Oscar H Franco John M Starr Kiang Liu Luigi Ferrucci Ozren Polasek James F Wilson Tiphaine Oudot-Mellakh Harry Campbell Pau Navarro Stefania Bandinelli Johan Eriksson Dorret I Boomsma Abbas Dehghan Robert Clarke Anders Hamsten Eric Boerwinkle J Wouter Jukema Silvia Naitza Paul M Ridker Henry Völzke Ian J Deary Alexander P Reiner David-Alexandre Trégouët Christopher J O'Donnell David P Strachan Annette Peters Nicholas L Smith |
| author_sort | Jens Baumert |
| collection | DOAJ |
| description | Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-scale meta-analyses of genome-wide interaction studies to identify possible interactions of genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentration. The present study included 80,607 subjects of European ancestry from 22 studies. Genome-wide interaction analyses were performed separately in each study for about 2.6 million single nucleotide polymorphisms (SNPs) across the 22 autosomal chromosomes. For each SNP and risk factor, we performed a linear regression under an additive genetic model including an interaction term between SNP and risk factor. Interaction estimates were meta-analysed using a fixed-effects model. No genome-wide significant interaction with smoking status, alcohol consumption or BMI was observed in the meta-analyses. The most suggestive interaction was found for smoking and rs10519203, located in the LOC123688 region on chromosome 15, with a p value of 6.2 × 10(-8). This large genome-wide interaction study including 80,607 participants found no strong evidence of interaction between genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentrations. Further studies are needed to yield deeper insight in the interplay between environmental factors and gene variants on the regulation of fibrinogen concentrations. |
| format | Article |
| id | doaj-art-2a5482c6a0714ca39c607dfcc7abcd70 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-2a5482c6a0714ca39c607dfcc7abcd702025-08-20T02:22:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11115610.1371/journal.pone.0111156No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects.Jens BaumertJie HuangBarbara McKnightMaria Sabater-LlealMaristella SteriAudrey Y ChuStella TrompetLorna M LopezMyriam FornageAlexander TeumerWeihong TangAlicja R RudnickaAnders MälarstigJouke-Jan HottengaMaryam KavousiJari LahtiToshiko TanakaCaroline HaywardJennifer E HuffmanPierre-Emmanuel MorangeLynda M RoseSaonli BasuAnn RumleyDavid J StottBrendan M BuckleyAnton J M de CraenSerena SannaMarco MasalaReiner BiffarGeorg HomuthAngela SilveiraBengt SennbladAnuj GoelHugh WatkinsMartina Müller-NurasyidRegina RückerlKent TaylorMing-Huei ChenEco J C de GeusAlbert HofmanJacqueline C M WittemanMoniek P M de MaatAarno PalotieGail DaviesDavid S SiscovickIvana KolcicSarah H WildJaejoon SongWendy L McArdleIan FordNaveed SattarDavid SchlessingerAnne GrotevendtMaria Grazia FranzosiThomas IlligMelanie WaldenbergerThomas LumleyGeoffrey H ToflerGonneke WillemsenAndré G UitterlindenFernando RivadeneiraKatri RäikkönenDaniel I ChasmanAaron R FolsomGordon D LoweRudi G J WestendorpP Eline SlagboomFrancesco CuccaHenri WallaschofskiRona J StrawbridgeUdo SeedorfWolfgang KoenigJoshua C BisKenneth J MukamalJenny van DongenElisabeth WidenOscar H FrancoJohn M StarrKiang LiuLuigi FerrucciOzren PolasekJames F WilsonTiphaine Oudot-MellakhHarry CampbellPau NavarroStefania BandinelliJohan ErikssonDorret I BoomsmaAbbas DehghanRobert ClarkeAnders HamstenEric BoerwinkleJ Wouter JukemaSilvia NaitzaPaul M RidkerHenry VölzkeIan J DearyAlexander P ReinerDavid-Alexandre TrégouëtChristopher J O'DonnellDavid P StrachanAnnette PetersNicholas L SmithPlasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-scale meta-analyses of genome-wide interaction studies to identify possible interactions of genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentration. The present study included 80,607 subjects of European ancestry from 22 studies. Genome-wide interaction analyses were performed separately in each study for about 2.6 million single nucleotide polymorphisms (SNPs) across the 22 autosomal chromosomes. For each SNP and risk factor, we performed a linear regression under an additive genetic model including an interaction term between SNP and risk factor. Interaction estimates were meta-analysed using a fixed-effects model. No genome-wide significant interaction with smoking status, alcohol consumption or BMI was observed in the meta-analyses. The most suggestive interaction was found for smoking and rs10519203, located in the LOC123688 region on chromosome 15, with a p value of 6.2 × 10(-8). This large genome-wide interaction study including 80,607 participants found no strong evidence of interaction between genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentrations. Further studies are needed to yield deeper insight in the interplay between environmental factors and gene variants on the regulation of fibrinogen concentrations.https://doi.org/10.1371/journal.pone.0111156 |
| spellingShingle | Jens Baumert Jie Huang Barbara McKnight Maria Sabater-Lleal Maristella Steri Audrey Y Chu Stella Trompet Lorna M Lopez Myriam Fornage Alexander Teumer Weihong Tang Alicja R Rudnicka Anders Mälarstig Jouke-Jan Hottenga Maryam Kavousi Jari Lahti Toshiko Tanaka Caroline Hayward Jennifer E Huffman Pierre-Emmanuel Morange Lynda M Rose Saonli Basu Ann Rumley David J Stott Brendan M Buckley Anton J M de Craen Serena Sanna Marco Masala Reiner Biffar Georg Homuth Angela Silveira Bengt Sennblad Anuj Goel Hugh Watkins Martina Müller-Nurasyid Regina Rückerl Kent Taylor Ming-Huei Chen Eco J C de Geus Albert Hofman Jacqueline C M Witteman Moniek P M de Maat Aarno Palotie Gail Davies David S Siscovick Ivana Kolcic Sarah H Wild Jaejoon Song Wendy L McArdle Ian Ford Naveed Sattar David Schlessinger Anne Grotevendt Maria Grazia Franzosi Thomas Illig Melanie Waldenberger Thomas Lumley Geoffrey H Tofler Gonneke Willemsen André G Uitterlinden Fernando Rivadeneira Katri Räikkönen Daniel I Chasman Aaron R Folsom Gordon D Lowe Rudi G J Westendorp P Eline Slagboom Francesco Cucca Henri Wallaschofski Rona J Strawbridge Udo Seedorf Wolfgang Koenig Joshua C Bis Kenneth J Mukamal Jenny van Dongen Elisabeth Widen Oscar H Franco John M Starr Kiang Liu Luigi Ferrucci Ozren Polasek James F Wilson Tiphaine Oudot-Mellakh Harry Campbell Pau Navarro Stefania Bandinelli Johan Eriksson Dorret I Boomsma Abbas Dehghan Robert Clarke Anders Hamsten Eric Boerwinkle J Wouter Jukema Silvia Naitza Paul M Ridker Henry Völzke Ian J Deary Alexander P Reiner David-Alexandre Trégouët Christopher J O'Donnell David P Strachan Annette Peters Nicholas L Smith No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. PLoS ONE |
| title | No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. |
| title_full | No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. |
| title_fullStr | No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. |
| title_full_unstemmed | No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. |
| title_short | No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. |
| title_sort | no evidence for genome wide interactions on plasma fibrinogen by smoking alcohol consumption and body mass index results from meta analyses of 80 607 subjects |
| url | https://doi.org/10.1371/journal.pone.0111156 |
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