Pregnancy is influenced by more than just embryo ploidy: a retrospective study on preimplantation genetic testing
Abstract Background Assisted reproductive technology (ART) has been widely used to treat infertility for more than four decades, but its efficacy is still lower than expected. Therefore, further exploration of the factors that affect the pregnancy outcome of ART treatment is necessary. Materials and...
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BMC
2025-03-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02457-y |
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| author | Sui-Bing Miao Geng Tian Zhen-Chuan Zhao Xiao-Wei Wang Jian Zhao Cai-Ping Geng |
| author_facet | Sui-Bing Miao Geng Tian Zhen-Chuan Zhao Xiao-Wei Wang Jian Zhao Cai-Ping Geng |
| author_sort | Sui-Bing Miao |
| collection | DOAJ |
| description | Abstract Background Assisted reproductive technology (ART) has been widely used to treat infertility for more than four decades, but its efficacy is still lower than expected. Therefore, further exploration of the factors that affect the pregnancy outcome of ART treatment is necessary. Materials and methods A retrospective study of chromosome rearrangement carrier couples who requested preimplantation genetic testing (PGT) for structural rearrangements at the Fourth Hospital of Shijiazhuang was conducted between February 2019 and December 2022. Multivariate logistic regression analysis was performed to determine the risk factors for pregnancy. Results In total, 113 couples were transferred with a single euploid blastocyst, and 77 couples achieved pregnancy. Women with good-quality embryos transferred had a higher probability of pregnancy than women with poor-quality embryos transferred (OR 6.149, 95% CI 2.026–18.658). The chance of pregnancy was higher in women with a pregnancy history than in women without a pregnancy history (OR 3.181, 95% CI 1.157–8.747). The progesterone level on the day of trigger was positively associated with pregnancy (OR 2.605, 95% CI 1.226–5.538). Conclusion Embryo quality is significantly associated with the pregnancy rate in patients treated with PGT. Embryo ploidy is just one of the factors affecting embryo development. Future studies should focus on the molecular mechanisms of embryo development and develop corresponding detection methods. |
| format | Article |
| id | doaj-art-2a51a19f25704f7b890878fd4d26b4ff |
| institution | DOAJ |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-2a51a19f25704f7b890878fd4d26b4ff2025-08-20T02:49:26ZengBMCEuropean Journal of Medical Research2047-783X2025-03-013011710.1186/s40001-025-02457-yPregnancy is influenced by more than just embryo ploidy: a retrospective study on preimplantation genetic testingSui-Bing Miao0Geng Tian1Zhen-Chuan Zhao2Xiao-Wei Wang3Jian Zhao4Cai-Ping Geng5Hebei Key Laboratory of Maternal and Fetal Medicine, Institute of Reproductive Medicine of Shijiazhuang, The Fourth Hospital of Shijiazhuang Affiliated to Hebei Medical UniversityCenter of Reproductive Medicine, The Fourth Hospital of Shijiazhuang Affiliated to Hebei Medical UniversityCenter of Reproductive Medicine, The Fourth Hospital of Shijiazhuang Affiliated to Hebei Medical UniversityCollege of Basic Medicine, Hebei Medical UniversityDepartment of Gynecology, The People’s Hospital of ShijiazhuangCenter of Reproductive Medicine, The Fourth Hospital of Shijiazhuang Affiliated to Hebei Medical UniversityAbstract Background Assisted reproductive technology (ART) has been widely used to treat infertility for more than four decades, but its efficacy is still lower than expected. Therefore, further exploration of the factors that affect the pregnancy outcome of ART treatment is necessary. Materials and methods A retrospective study of chromosome rearrangement carrier couples who requested preimplantation genetic testing (PGT) for structural rearrangements at the Fourth Hospital of Shijiazhuang was conducted between February 2019 and December 2022. Multivariate logistic regression analysis was performed to determine the risk factors for pregnancy. Results In total, 113 couples were transferred with a single euploid blastocyst, and 77 couples achieved pregnancy. Women with good-quality embryos transferred had a higher probability of pregnancy than women with poor-quality embryos transferred (OR 6.149, 95% CI 2.026–18.658). The chance of pregnancy was higher in women with a pregnancy history than in women without a pregnancy history (OR 3.181, 95% CI 1.157–8.747). The progesterone level on the day of trigger was positively associated with pregnancy (OR 2.605, 95% CI 1.226–5.538). Conclusion Embryo quality is significantly associated with the pregnancy rate in patients treated with PGT. Embryo ploidy is just one of the factors affecting embryo development. Future studies should focus on the molecular mechanisms of embryo development and develop corresponding detection methods.https://doi.org/10.1186/s40001-025-02457-yChromosomal structural rearrangementsPreimplantation genetic testingEmbryo qualityPregnancy outcome |
| spellingShingle | Sui-Bing Miao Geng Tian Zhen-Chuan Zhao Xiao-Wei Wang Jian Zhao Cai-Ping Geng Pregnancy is influenced by more than just embryo ploidy: a retrospective study on preimplantation genetic testing European Journal of Medical Research Chromosomal structural rearrangements Preimplantation genetic testing Embryo quality Pregnancy outcome |
| title | Pregnancy is influenced by more than just embryo ploidy: a retrospective study on preimplantation genetic testing |
| title_full | Pregnancy is influenced by more than just embryo ploidy: a retrospective study on preimplantation genetic testing |
| title_fullStr | Pregnancy is influenced by more than just embryo ploidy: a retrospective study on preimplantation genetic testing |
| title_full_unstemmed | Pregnancy is influenced by more than just embryo ploidy: a retrospective study on preimplantation genetic testing |
| title_short | Pregnancy is influenced by more than just embryo ploidy: a retrospective study on preimplantation genetic testing |
| title_sort | pregnancy is influenced by more than just embryo ploidy a retrospective study on preimplantation genetic testing |
| topic | Chromosomal structural rearrangements Preimplantation genetic testing Embryo quality Pregnancy outcome |
| url | https://doi.org/10.1186/s40001-025-02457-y |
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