Decoding auditory working memory content from EEG responses to auditory-cortical TMS
Working memory (WM), short term maintenance of information for goal directed behavior, is essential to human cognition. Identifying the neural mechanisms supporting WM is a focal point of neuroscientific research. One prominent theory hypothesizes that WM content is carried in “activity-silent” brai...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
|
| Series: | Brain Stimulation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X25000518 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850129621655224320 |
|---|---|
| author | Işıl Uluç Mohammad Daneshzand Mainak Jas Parker Kotlarz Kaisu Lankinen Jennifer L. Fiedler Fahimeh Mamashli Netri Pajankar Tori Turpin Lucia Navarro de Lara Padmavathi Sundaram Tommi Raij Aapo Nummenmaa Jyrki Ahveninen |
| author_facet | Işıl Uluç Mohammad Daneshzand Mainak Jas Parker Kotlarz Kaisu Lankinen Jennifer L. Fiedler Fahimeh Mamashli Netri Pajankar Tori Turpin Lucia Navarro de Lara Padmavathi Sundaram Tommi Raij Aapo Nummenmaa Jyrki Ahveninen |
| author_sort | Işıl Uluç |
| collection | DOAJ |
| description | Working memory (WM), short term maintenance of information for goal directed behavior, is essential to human cognition. Identifying the neural mechanisms supporting WM is a focal point of neuroscientific research. One prominent theory hypothesizes that WM content is carried in “activity-silent” brain states involving short-term synaptic changes. Information carried in such brain states could be decodable from content-specific changes in responses to unrelated “impulse stimuli”. Here, we used single-pulse transcranial magnetic stimulation (spTMS) as the impulse stimulus and then decoded content maintained in WM from EEG using multivariate pattern analysis (MVPA) with robust non-parametric permutation testing. The decoding accuracy of WM content significantly enhanced after spTMS was delivered to the posterior superior temporal cortex during WM maintenance. Our results show that WM maintenance involves brain states, which are activity silent relative to other intrinsic processes visible in the EEG signal. |
| format | Article |
| id | doaj-art-2a5145e7151a46ee92139b278cbce61f |
| institution | OA Journals |
| issn | 1935-861X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Stimulation |
| spelling | doaj-art-2a5145e7151a46ee92139b278cbce61f2025-08-20T02:32:54ZengElsevierBrain Stimulation1935-861X2025-05-0118364965810.1016/j.brs.2025.02.020Decoding auditory working memory content from EEG responses to auditory-cortical TMSIşıl Uluç0Mohammad Daneshzand1Mainak Jas2Parker Kotlarz3Kaisu Lankinen4Jennifer L. Fiedler5Fahimeh Mamashli6Netri Pajankar7Tori Turpin8Lucia Navarro de Lara9Padmavathi Sundaram10Tommi Raij11Aapo Nummenmaa12Jyrki Ahveninen13Athinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USA; Corresponding author. Department of Radiology, Massachusetts General Hospital, CNY 149, 13th St. A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, 02129, USA. iuluc@mgh.harvard.eduAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USAAthinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USAWorking memory (WM), short term maintenance of information for goal directed behavior, is essential to human cognition. Identifying the neural mechanisms supporting WM is a focal point of neuroscientific research. One prominent theory hypothesizes that WM content is carried in “activity-silent” brain states involving short-term synaptic changes. Information carried in such brain states could be decodable from content-specific changes in responses to unrelated “impulse stimuli”. Here, we used single-pulse transcranial magnetic stimulation (spTMS) as the impulse stimulus and then decoded content maintained in WM from EEG using multivariate pattern analysis (MVPA) with robust non-parametric permutation testing. The decoding accuracy of WM content significantly enhanced after spTMS was delivered to the posterior superior temporal cortex during WM maintenance. Our results show that WM maintenance involves brain states, which are activity silent relative to other intrinsic processes visible in the EEG signal.http://www.sciencedirect.com/science/article/pii/S1935861X25000518Working memoryAuditory working memoryTranscranial magnetic stimulationTMS-EEGMVPA |
| spellingShingle | Işıl Uluç Mohammad Daneshzand Mainak Jas Parker Kotlarz Kaisu Lankinen Jennifer L. Fiedler Fahimeh Mamashli Netri Pajankar Tori Turpin Lucia Navarro de Lara Padmavathi Sundaram Tommi Raij Aapo Nummenmaa Jyrki Ahveninen Decoding auditory working memory content from EEG responses to auditory-cortical TMS Brain Stimulation Working memory Auditory working memory Transcranial magnetic stimulation TMS-EEG MVPA |
| title | Decoding auditory working memory content from EEG responses to auditory-cortical TMS |
| title_full | Decoding auditory working memory content from EEG responses to auditory-cortical TMS |
| title_fullStr | Decoding auditory working memory content from EEG responses to auditory-cortical TMS |
| title_full_unstemmed | Decoding auditory working memory content from EEG responses to auditory-cortical TMS |
| title_short | Decoding auditory working memory content from EEG responses to auditory-cortical TMS |
| title_sort | decoding auditory working memory content from eeg responses to auditory cortical tms |
| topic | Working memory Auditory working memory Transcranial magnetic stimulation TMS-EEG MVPA |
| url | http://www.sciencedirect.com/science/article/pii/S1935861X25000518 |
| work_keys_str_mv | AT isıluluc decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT mohammaddaneshzand decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT mainakjas decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT parkerkotlarz decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT kaisulankinen decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT jenniferlfiedler decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT fahimehmamashli decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT netripajankar decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT toriturpin decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT lucianavarrodelara decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT padmavathisundaram decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT tommiraij decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT aaponummenmaa decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms AT jyrkiahveninen decodingauditoryworkingmemorycontentfromeegresponsestoauditorycorticaltms |