Alpha-L-fucosidase as a putative prognostic biomarker in breast cancer
Search for reliable biomarkers for predicting progression of breast cancer is essential in managing the disease. So, we are trying to provide new insights into the potential role of alpha-fucosidase (AFU) as a putative prognostic biomarker in breast cancer as compared to classic markers. The study i...
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2024-06-01
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| Series: | The Ukrainian Biochemical Journal |
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| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2024/06/Hamodat_96_3.pdf |
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| author | Z. M. A. A. Hamodat H. H. Abdulwahhab A. R. M. T. Hamodat |
| author_facet | Z. M. A. A. Hamodat H. H. Abdulwahhab A. R. M. T. Hamodat |
| author_sort | Z. M. A. A. Hamodat |
| collection | DOAJ |
| description | Search for reliable biomarkers for predicting progression of breast cancer is essential in managing the disease. So, we are trying to provide new insights into the potential role of alpha-fucosidase (AFU) as a putative prognostic biomarker in breast cancer as compared to classic markers. The study included 56 women with breast cancer; 25 had early breast cancer, and the rest (31) had metastatic breast cancer. Thirty healthy women were considered a control group. Early breast cancer patients had a significantly increased (P ≤ 0.0001) AFU level compared with the control group. A non-significant difference in the De-ritis ratio appeared for early breast cancer compared with control. Metastatic breast cancer had a significantly (P ≤ 0.0001) increased AFU and De-ritis ratio compared with early breast cancer and the control group. A positive significant (P = 0.01) correlation exists between AFU level, age factor (r = 0.295), and the De-ritis ratio in breast cancer patients. We can conclude that it is possible to consider alpha-L-fucosidase (AFU) as a putative prognostic biomarker in breast cancer more potent than the ratio of De-Ritis. Moreover, the coincidence of elevated AFU and De-ritis levels in metastatic breast cancer gives us an idea of the stage of the disease. |
| format | Article |
| id | doaj-art-2a4f3cafb11b4de98fa4bae3abb47efc |
| institution | DOAJ |
| issn | 2409-4943 2413-5003 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj-art-2a4f3cafb11b4de98fa4bae3abb47efc2025-08-20T03:15:39ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032024-06-01963576510.15407/ubj96.03.057Alpha-L-fucosidase as a putative prognostic biomarker in breast cancerZ. M. A. A. Hamodat0H. H. Abdulwahhab1A. R. M. T. Hamodat2Department of Chemistry, College of Science, University of Mosul, IraqNorthern Technical University, AL-dour, IraqMosul Center for Cardiac Medicine and Surgery, Mosul, IraqSearch for reliable biomarkers for predicting progression of breast cancer is essential in managing the disease. So, we are trying to provide new insights into the potential role of alpha-fucosidase (AFU) as a putative prognostic biomarker in breast cancer as compared to classic markers. The study included 56 women with breast cancer; 25 had early breast cancer, and the rest (31) had metastatic breast cancer. Thirty healthy women were considered a control group. Early breast cancer patients had a significantly increased (P ≤ 0.0001) AFU level compared with the control group. A non-significant difference in the De-ritis ratio appeared for early breast cancer compared with control. Metastatic breast cancer had a significantly (P ≤ 0.0001) increased AFU and De-ritis ratio compared with early breast cancer and the control group. A positive significant (P = 0.01) correlation exists between AFU level, age factor (r = 0.295), and the De-ritis ratio in breast cancer patients. We can conclude that it is possible to consider alpha-L-fucosidase (AFU) as a putative prognostic biomarker in breast cancer more potent than the ratio of De-Ritis. Moreover, the coincidence of elevated AFU and De-ritis levels in metastatic breast cancer gives us an idea of the stage of the disease.http://ukrbiochemjournal.org/wp-content/uploads/2024/06/Hamodat_96_3.pdfalpha-l-fucosidaseearly breast cancermetastasisthe de-ritis ratio |
| spellingShingle | Z. M. A. A. Hamodat H. H. Abdulwahhab A. R. M. T. Hamodat Alpha-L-fucosidase as a putative prognostic biomarker in breast cancer The Ukrainian Biochemical Journal alpha-l-fucosidase early breast cancer metastasis the de-ritis ratio |
| title | Alpha-L-fucosidase as a putative prognostic biomarker in breast cancer |
| title_full | Alpha-L-fucosidase as a putative prognostic biomarker in breast cancer |
| title_fullStr | Alpha-L-fucosidase as a putative prognostic biomarker in breast cancer |
| title_full_unstemmed | Alpha-L-fucosidase as a putative prognostic biomarker in breast cancer |
| title_short | Alpha-L-fucosidase as a putative prognostic biomarker in breast cancer |
| title_sort | alpha l fucosidase as a putative prognostic biomarker in breast cancer |
| topic | alpha-l-fucosidase early breast cancer metastasis the de-ritis ratio |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2024/06/Hamodat_96_3.pdf |
| work_keys_str_mv | AT zmaahamodat alphalfucosidaseasaputativeprognosticbiomarkerinbreastcancer AT hhabdulwahhab alphalfucosidaseasaputativeprognosticbiomarkerinbreastcancer AT armthamodat alphalfucosidaseasaputativeprognosticbiomarkerinbreastcancer |