The gut-heart axis: unveiling the roles of gut microbiota in cardiovascular diseases
The gut microbiome refers to the collective genomes of the approximately 1,000–1,150 microbial species found in the human gut, called the gut microbiota. Changing the gut microbiota composition has been shown to affect cardiovascular health significantly. Numerous studies have demonstrated the part...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1572948/full |
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| author | Yuan Zhang Yuan Zhang Huimin Wu Mu Jin Guirong Feng Sheng Wang Sheng Wang |
| author_facet | Yuan Zhang Yuan Zhang Huimin Wu Mu Jin Guirong Feng Sheng Wang Sheng Wang |
| author_sort | Yuan Zhang |
| collection | DOAJ |
| description | The gut microbiome refers to the collective genomes of the approximately 1,000–1,150 microbial species found in the human gut, called the gut microbiota. Changing the gut microbiota composition has been shown to affect cardiovascular health significantly. Numerous studies have demonstrated the part that gut microbiota and its metabolites play in the development and course of several illnesses, including colon cancer, heart failure, stroke, hypertension, and inflammatory bowel disease. With cardiovascular diseases responsible for more than 31% of all fatalities globally, conditions like hypertension, atherosclerosis, and heart failure are serious global health issues. Developing preventive measures to fight cardiovascular diseases requires understanding how the gut microbiota interacts with the cardiovascular system. Understanding the distinctive gut microbiota linked to cardiovascular diseases has been made possible by microbial sequencing analysis. The gut microbiota and cardiovascular diseases are closely related, and more profound knowledge of this association may result in treatment strategies and broad guidelines for enhancing cardiovascular health through gut microbiome modification. This review summarizes the role of gut microbiota in cardiovascular diseases, highlighting their influence on disease progression and potential therapeutic implications. |
| format | Article |
| id | doaj-art-2a4f2d2f491c4220b3094eac47403ced |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-2a4f2d2f491c4220b3094eac47403ced2025-08-20T03:48:23ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-05-011210.3389/fcvm.2025.15729481572948The gut-heart axis: unveiling the roles of gut microbiota in cardiovascular diseasesYuan Zhang0Yuan Zhang1Huimin Wu2Mu Jin3Guirong Feng4Sheng Wang5Sheng Wang6Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Anesthesiology, International Mongolian Hospital of Inner Mongolia, Hohhot, Inner Mongolia, ChinaDepartment of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Anesthesiology, International Mongolian Hospital of Inner Mongolia, Hohhot, Inner Mongolia, ChinaDepartment of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaLinzhi People’s Hospital, Linzhi, Tibet, ChinaThe gut microbiome refers to the collective genomes of the approximately 1,000–1,150 microbial species found in the human gut, called the gut microbiota. Changing the gut microbiota composition has been shown to affect cardiovascular health significantly. Numerous studies have demonstrated the part that gut microbiota and its metabolites play in the development and course of several illnesses, including colon cancer, heart failure, stroke, hypertension, and inflammatory bowel disease. With cardiovascular diseases responsible for more than 31% of all fatalities globally, conditions like hypertension, atherosclerosis, and heart failure are serious global health issues. Developing preventive measures to fight cardiovascular diseases requires understanding how the gut microbiota interacts with the cardiovascular system. Understanding the distinctive gut microbiota linked to cardiovascular diseases has been made possible by microbial sequencing analysis. The gut microbiota and cardiovascular diseases are closely related, and more profound knowledge of this association may result in treatment strategies and broad guidelines for enhancing cardiovascular health through gut microbiome modification. This review summarizes the role of gut microbiota in cardiovascular diseases, highlighting their influence on disease progression and potential therapeutic implications.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1572948/fullgut microbiotacardiovascular diseasesheart failuremetabolitesmicrobiota composition |
| spellingShingle | Yuan Zhang Yuan Zhang Huimin Wu Mu Jin Guirong Feng Sheng Wang Sheng Wang The gut-heart axis: unveiling the roles of gut microbiota in cardiovascular diseases Frontiers in Cardiovascular Medicine gut microbiota cardiovascular diseases heart failure metabolites microbiota composition |
| title | The gut-heart axis: unveiling the roles of gut microbiota in cardiovascular diseases |
| title_full | The gut-heart axis: unveiling the roles of gut microbiota in cardiovascular diseases |
| title_fullStr | The gut-heart axis: unveiling the roles of gut microbiota in cardiovascular diseases |
| title_full_unstemmed | The gut-heart axis: unveiling the roles of gut microbiota in cardiovascular diseases |
| title_short | The gut-heart axis: unveiling the roles of gut microbiota in cardiovascular diseases |
| title_sort | gut heart axis unveiling the roles of gut microbiota in cardiovascular diseases |
| topic | gut microbiota cardiovascular diseases heart failure metabolites microbiota composition |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1572948/full |
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