Efficacy and Safety of a Diet Enriched with EPA and DHA, Turmeric Extract and Hydrolysed Collagen in Management of Naturally Occurring Osteoarthritis in Cats: A Prospective, Randomised, Blinded, Placebo- and Time-Controlled Study
This study evaluated a therapeutic diet high in eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) of marine source (EPA:DHA ratio 0.69:1), turmeric extract, and hydrolysed collagen in cats (<i>N</i> = 30) with naturally occurring osteoarthritis (OA) over a 13-week (W) period, followe...
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MDPI AG
2024-11-01
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| Online Access: | https://www.mdpi.com/2076-2615/14/22/3298 |
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| author | Manuela Lefort-Holguin Aliénor Delsart Colombe Otis Maxim Moreau Maude Barbeau-Grégoire Florence Mellet Vincent Biourge Bertrand Lussier Jean-Pierre Pelletier Johanne Martel-Pelletier Eric Troncy |
| author_facet | Manuela Lefort-Holguin Aliénor Delsart Colombe Otis Maxim Moreau Maude Barbeau-Grégoire Florence Mellet Vincent Biourge Bertrand Lussier Jean-Pierre Pelletier Johanne Martel-Pelletier Eric Troncy |
| author_sort | Manuela Lefort-Holguin |
| collection | DOAJ |
| description | This study evaluated a therapeutic diet high in eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) of marine source (EPA:DHA ratio 0.69:1), turmeric extract, and hydrolysed collagen in cats (<i>N</i> = 30) with naturally occurring osteoarthritis (OA) over a 13-week (W) period, followed by a 4-W washout, using four previously validated pain/functional outcomes. Compared to the placebo diet, the therapeutic diet significantly improved peak vertical force (<i>p</i> = 0.017; W16, 64% responders), correlating to enhanced weight bearing; stair assay compliance (<i>p</i> < 0.001; W16, 87% responders), reflecting reduced fatigue related to OA pain; night-time actimetry (cohort effect; <i>p</i> = 0.05, 67% responders), suggesting greater spontaneous mobility and comfort; and MI-CAT(V) score (cohort effect; <i>p</i> < 0.001, 80% responders), indicating reduced functional impairments. The earliest therapeutic response was observed at W06, marked by an inflection point between actimetric linear regressions of both cohorts, confirmed by significant MI-CAT(V) differences (<i>p</i> < 0.007; W08; W12; W16). The MI-CAT(V) clinical metrology instrument was validated for inter-rater reliability, minimal placebo effect (<15% responders), and OA severity clustering. Despite baseline differences in biomechanical assessments (<i>p</i> < 0.05), both moderate and severe OA clusters responded equally positively to the therapeutic diet. Based on all outcomes, the therapeutic diet showed promise for the long-term management of feline OA, with no observed side effects. |
| format | Article |
| id | doaj-art-2a4e7af826f34c66bf4ba417ecab75d5 |
| institution | OA Journals |
| issn | 2076-2615 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj-art-2a4e7af826f34c66bf4ba417ecab75d52025-08-20T02:08:11ZengMDPI AGAnimals2076-26152024-11-011422329810.3390/ani14223298Efficacy and Safety of a Diet Enriched with EPA and DHA, Turmeric Extract and Hydrolysed Collagen in Management of Naturally Occurring Osteoarthritis in Cats: A Prospective, Randomised, Blinded, Placebo- and Time-Controlled StudyManuela Lefort-Holguin0Aliénor Delsart1Colombe Otis2Maxim Moreau3Maude Barbeau-Grégoire4Florence Mellet5Vincent Biourge6Bertrand Lussier7Jean-Pierre Pelletier8Johanne Martel-Pelletier9Eric Troncy10Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, CanadaGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, CanadaGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, CanadaGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, CanadaGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, CanadaRoyal-Canin S.A.S., F-30470 Aimargues, FranceRoyal-Canin S.A.S., F-30470 Aimargues, FranceGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, CanadaOsteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), Montréal, QC H2X 0A9, CanadaOsteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), Montréal, QC H2X 0A9, CanadaGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, CanadaThis study evaluated a therapeutic diet high in eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) of marine source (EPA:DHA ratio 0.69:1), turmeric extract, and hydrolysed collagen in cats (<i>N</i> = 30) with naturally occurring osteoarthritis (OA) over a 13-week (W) period, followed by a 4-W washout, using four previously validated pain/functional outcomes. Compared to the placebo diet, the therapeutic diet significantly improved peak vertical force (<i>p</i> = 0.017; W16, 64% responders), correlating to enhanced weight bearing; stair assay compliance (<i>p</i> < 0.001; W16, 87% responders), reflecting reduced fatigue related to OA pain; night-time actimetry (cohort effect; <i>p</i> = 0.05, 67% responders), suggesting greater spontaneous mobility and comfort; and MI-CAT(V) score (cohort effect; <i>p</i> < 0.001, 80% responders), indicating reduced functional impairments. The earliest therapeutic response was observed at W06, marked by an inflection point between actimetric linear regressions of both cohorts, confirmed by significant MI-CAT(V) differences (<i>p</i> < 0.007; W08; W12; W16). The MI-CAT(V) clinical metrology instrument was validated for inter-rater reliability, minimal placebo effect (<15% responders), and OA severity clustering. Despite baseline differences in biomechanical assessments (<i>p</i> < 0.05), both moderate and severe OA clusters responded equally positively to the therapeutic diet. Based on all outcomes, the therapeutic diet showed promise for the long-term management of feline OA, with no observed side effects.https://www.mdpi.com/2076-2615/14/22/3298omega-3curcuminoidfelinechronic painbiomechanicalfunctional alterations |
| spellingShingle | Manuela Lefort-Holguin Aliénor Delsart Colombe Otis Maxim Moreau Maude Barbeau-Grégoire Florence Mellet Vincent Biourge Bertrand Lussier Jean-Pierre Pelletier Johanne Martel-Pelletier Eric Troncy Efficacy and Safety of a Diet Enriched with EPA and DHA, Turmeric Extract and Hydrolysed Collagen in Management of Naturally Occurring Osteoarthritis in Cats: A Prospective, Randomised, Blinded, Placebo- and Time-Controlled Study Animals omega-3 curcuminoid feline chronic pain biomechanical functional alterations |
| title | Efficacy and Safety of a Diet Enriched with EPA and DHA, Turmeric Extract and Hydrolysed Collagen in Management of Naturally Occurring Osteoarthritis in Cats: A Prospective, Randomised, Blinded, Placebo- and Time-Controlled Study |
| title_full | Efficacy and Safety of a Diet Enriched with EPA and DHA, Turmeric Extract and Hydrolysed Collagen in Management of Naturally Occurring Osteoarthritis in Cats: A Prospective, Randomised, Blinded, Placebo- and Time-Controlled Study |
| title_fullStr | Efficacy and Safety of a Diet Enriched with EPA and DHA, Turmeric Extract and Hydrolysed Collagen in Management of Naturally Occurring Osteoarthritis in Cats: A Prospective, Randomised, Blinded, Placebo- and Time-Controlled Study |
| title_full_unstemmed | Efficacy and Safety of a Diet Enriched with EPA and DHA, Turmeric Extract and Hydrolysed Collagen in Management of Naturally Occurring Osteoarthritis in Cats: A Prospective, Randomised, Blinded, Placebo- and Time-Controlled Study |
| title_short | Efficacy and Safety of a Diet Enriched with EPA and DHA, Turmeric Extract and Hydrolysed Collagen in Management of Naturally Occurring Osteoarthritis in Cats: A Prospective, Randomised, Blinded, Placebo- and Time-Controlled Study |
| title_sort | efficacy and safety of a diet enriched with epa and dha turmeric extract and hydrolysed collagen in management of naturally occurring osteoarthritis in cats a prospective randomised blinded placebo and time controlled study |
| topic | omega-3 curcuminoid feline chronic pain biomechanical functional alterations |
| url | https://www.mdpi.com/2076-2615/14/22/3298 |
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