19-Gauge Versus 22-Gauge Franseen Needles, Comparison of the Histological Diagnostic Capability of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Autoimmune Pancreatitis: A Multicenter Retrospective Cohort Study
<b>Background/Objectives</b>: Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is a useful procedure for obtaining histological specimens. However, its utility in diagnosing autoimmune pancreatitis (AIP) has not yet been well studied. This study aimed to assess the diagnostic ca...
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2025-06-01
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| author | Shota Iwata Takuji Iwashita Yosuke Ohashi Akihiko Senju Ryuichi Tezuka Shinya Uemura Kensaku Yoshida Akinori Maruta Yuhei Iwasa Mitsuru Okuno Keisuke Iwata Tatsuhiko Miyazaki Masahito Shimizu |
| author_facet | Shota Iwata Takuji Iwashita Yosuke Ohashi Akihiko Senju Ryuichi Tezuka Shinya Uemura Kensaku Yoshida Akinori Maruta Yuhei Iwasa Mitsuru Okuno Keisuke Iwata Tatsuhiko Miyazaki Masahito Shimizu |
| author_sort | Shota Iwata |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is a useful procedure for obtaining histological specimens. However, its utility in diagnosing autoimmune pancreatitis (AIP) has not yet been well studied. This study aimed to assess the diagnostic capability of EUS-FNB for AIP by comparing a 19-gauge Franseen needle (19FR) and a 22-gauge Franseen needle (22FR). <b>Methods</b>: This study included patients with a final diagnosis of AIP undergoing EUS-FNB for pancreatic lesions between January 2014 and February 2023. All patients underwent EUS-FNB with either 19FR or 22FR. Histological findings were evaluated according to the International Consensus Diagnostic Criteria (ICDC). The primary outcome was the diagnostic yield of Level 1 (≥3 ICDC items) or Level 2 (2 ICDC items). <b>Results</b>: The 19FR group included 31 patients, and the 22FR group included 36 patients. The Level 1 diagnostic rate was significantly higher in the 19FR group than in the 22FR group (90.3% vs. 61.1%, <i>p</i> = 0.010). No significant difference was observed in the Level 2 diagnostic rate. The 19FR group yielded significantly larger histological tissue samples than the 22FR group (median area: 9.19 mm<sup>2</sup>/session vs. 3.36 mm<sup>2</sup>/session, <i>p</i> < 0.001). The analysis demonstrated a positive correlation between tissue area and the number of histological diagnostic items obtained. <b>Conclusions</b>: EUS-FNB performed with the 19FR provided larger histological specimens and a higher histological diagnostic yield than the 22FR in the diagnosis of AIP. Obtaining a larger amount of tissue may facilitate a definitive diagnosis of AIP. |
| format | Article |
| id | doaj-art-2a4ddda31f60441b9f0307bb1ee20080 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-2a4ddda31f60441b9f0307bb1ee200802025-08-20T03:27:28ZengMDPI AGDiagnostics2075-44182025-06-011512149610.3390/diagnostics1512149619-Gauge Versus 22-Gauge Franseen Needles, Comparison of the Histological Diagnostic Capability of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Autoimmune Pancreatitis: A Multicenter Retrospective Cohort StudyShota Iwata0Takuji Iwashita1Yosuke Ohashi2Akihiko Senju3Ryuichi Tezuka4Shinya Uemura5Kensaku Yoshida6Akinori Maruta7Yuhei Iwasa8Mitsuru Okuno9Keisuke Iwata10Tatsuhiko Miyazaki11Masahito Shimizu12First Department of Internal Medicine, Gifu University Hospital, Gifu 501-1194, JapanFirst Department of Internal Medicine, Gifu University Hospital, Gifu 501-1194, JapanFirst Department of Internal Medicine, Gifu University Hospital, Gifu 501-1194, JapanFirst Department of Internal Medicine, Gifu University Hospital, Gifu 501-1194, JapanFirst Department of Internal Medicine, Gifu University Hospital, Gifu 501-1194, JapanFirst Department of Internal Medicine, Gifu University Hospital, Gifu 501-1194, JapanDepartment of Gastroenterology, Gifu Prefectural General Medical Center, Gifu 500-8717, JapanDepartment of Gastroenterology, Gifu Prefectural General Medical Center, Gifu 500-8717, JapanDepartment of Gastroenterology, Gifu Municipal Hospital, Gifu 500-8513, JapanDepartment of Gastroenterology, Gifu Municipal Hospital, Gifu 500-8513, JapanDepartment of Gastroenterology, Gifu Municipal Hospital, Gifu 500-8513, JapanDepartment of Pathology, Gifu University Hospital, Gifu 501-1194, JapanFirst Department of Internal Medicine, Gifu University Hospital, Gifu 501-1194, Japan<b>Background/Objectives</b>: Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is a useful procedure for obtaining histological specimens. However, its utility in diagnosing autoimmune pancreatitis (AIP) has not yet been well studied. This study aimed to assess the diagnostic capability of EUS-FNB for AIP by comparing a 19-gauge Franseen needle (19FR) and a 22-gauge Franseen needle (22FR). <b>Methods</b>: This study included patients with a final diagnosis of AIP undergoing EUS-FNB for pancreatic lesions between January 2014 and February 2023. All patients underwent EUS-FNB with either 19FR or 22FR. Histological findings were evaluated according to the International Consensus Diagnostic Criteria (ICDC). The primary outcome was the diagnostic yield of Level 1 (≥3 ICDC items) or Level 2 (2 ICDC items). <b>Results</b>: The 19FR group included 31 patients, and the 22FR group included 36 patients. The Level 1 diagnostic rate was significantly higher in the 19FR group than in the 22FR group (90.3% vs. 61.1%, <i>p</i> = 0.010). No significant difference was observed in the Level 2 diagnostic rate. The 19FR group yielded significantly larger histological tissue samples than the 22FR group (median area: 9.19 mm<sup>2</sup>/session vs. 3.36 mm<sup>2</sup>/session, <i>p</i> < 0.001). The analysis demonstrated a positive correlation between tissue area and the number of histological diagnostic items obtained. <b>Conclusions</b>: EUS-FNB performed with the 19FR provided larger histological specimens and a higher histological diagnostic yield than the 22FR in the diagnosis of AIP. Obtaining a larger amount of tissue may facilitate a definitive diagnosis of AIP.https://www.mdpi.com/2075-4418/15/12/1496autoimmune pancreatitis19-gauge22-gaugeendoscopic ultrasound-guided fine needle biopsyFranseen needle |
| spellingShingle | Shota Iwata Takuji Iwashita Yosuke Ohashi Akihiko Senju Ryuichi Tezuka Shinya Uemura Kensaku Yoshida Akinori Maruta Yuhei Iwasa Mitsuru Okuno Keisuke Iwata Tatsuhiko Miyazaki Masahito Shimizu 19-Gauge Versus 22-Gauge Franseen Needles, Comparison of the Histological Diagnostic Capability of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Autoimmune Pancreatitis: A Multicenter Retrospective Cohort Study Diagnostics autoimmune pancreatitis 19-gauge 22-gauge endoscopic ultrasound-guided fine needle biopsy Franseen needle |
| title | 19-Gauge Versus 22-Gauge Franseen Needles, Comparison of the Histological Diagnostic Capability of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Autoimmune Pancreatitis: A Multicenter Retrospective Cohort Study |
| title_full | 19-Gauge Versus 22-Gauge Franseen Needles, Comparison of the Histological Diagnostic Capability of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Autoimmune Pancreatitis: A Multicenter Retrospective Cohort Study |
| title_fullStr | 19-Gauge Versus 22-Gauge Franseen Needles, Comparison of the Histological Diagnostic Capability of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Autoimmune Pancreatitis: A Multicenter Retrospective Cohort Study |
| title_full_unstemmed | 19-Gauge Versus 22-Gauge Franseen Needles, Comparison of the Histological Diagnostic Capability of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Autoimmune Pancreatitis: A Multicenter Retrospective Cohort Study |
| title_short | 19-Gauge Versus 22-Gauge Franseen Needles, Comparison of the Histological Diagnostic Capability of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Autoimmune Pancreatitis: A Multicenter Retrospective Cohort Study |
| title_sort | 19 gauge versus 22 gauge franseen needles comparison of the histological diagnostic capability of endoscopic ultrasound guided fine needle biopsy for autoimmune pancreatitis a multicenter retrospective cohort study |
| topic | autoimmune pancreatitis 19-gauge 22-gauge endoscopic ultrasound-guided fine needle biopsy Franseen needle |
| url | https://www.mdpi.com/2075-4418/15/12/1496 |
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