Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age.
<h4>Introduction</h4>The relationship between benzodiazepines, opioids and tricyclic antidepressants and trauma is of great importance because of increased consumption and the growing evidence of a positive association among older adults. The objective of this study was to determine the...
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Public Library of Science (PLoS)
2020-01-01
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| author | Sergio Cordovilla-Guardia Tania Bautista Molina Cristina Franco-Antonio Esperanza Santano-Mogena Raquel Vilar-López |
| author_facet | Sergio Cordovilla-Guardia Tania Bautista Molina Cristina Franco-Antonio Esperanza Santano-Mogena Raquel Vilar-López |
| author_sort | Sergio Cordovilla-Guardia |
| collection | DOAJ |
| description | <h4>Introduction</h4>The relationship between benzodiazepines, opioids and tricyclic antidepressants and trauma is of great importance because of increased consumption and the growing evidence of a positive association among older adults. The objective of this study was to determine the effect size of the association between the consumption of psychotropic medications /opioids and falls in patients who have suffered trauma by studying the role of other variables in this relationship.<h4>Method</h4>From 2011 to 2016, the presence of benzodiazepines, opioids and tricyclic antidepressants and other drugs in 1060 patients admitted for trauma at a level I trauma hospital was analysed. Multivariate models were used to measure the adjusted effect size of the association between consumption of benzodiazepines, opioids and tricyclic antidepressants and falls, and the effect of age on this association was studied.<h4>Results</h4>A total of 192 patients tested positive for benzodiazepines, opioids and tricyclic antidepressants, with same-level falls being the most frequent mechanism of injury in this group (40.1%), with an odds ratio of 1.96 (1.40-2.75), p < 0.001. Once other covariates were introduced, this association was not observed, leaving only age, gender (woman) and, to a lesser extent, sensory conditions as variables associated with falls. Age acted as an effect modifier between benzodiazepines, opioids and tricyclic antidepressants and falls, with significant effect sizes starting at 51.9 years of age.<h4>Conclusions</h4>The association between the consumption of benzodiazepines, opioids and tricyclic antidepressants and falls in patients admitted for trauma is conditioned by other confounding variables, with age being the most influential confounding variable. |
| format | Article |
| id | doaj-art-2a4d764bc3924a6e9476cd58204ebcdc |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-2a4d764bc3924a6e9476cd58204ebcdc2025-08-20T02:54:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01151e022769610.1371/journal.pone.0227696Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age.Sergio Cordovilla-GuardiaTania Bautista MolinaCristina Franco-AntonioEsperanza Santano-MogenaRaquel Vilar-López<h4>Introduction</h4>The relationship between benzodiazepines, opioids and tricyclic antidepressants and trauma is of great importance because of increased consumption and the growing evidence of a positive association among older adults. The objective of this study was to determine the effect size of the association between the consumption of psychotropic medications /opioids and falls in patients who have suffered trauma by studying the role of other variables in this relationship.<h4>Method</h4>From 2011 to 2016, the presence of benzodiazepines, opioids and tricyclic antidepressants and other drugs in 1060 patients admitted for trauma at a level I trauma hospital was analysed. Multivariate models were used to measure the adjusted effect size of the association between consumption of benzodiazepines, opioids and tricyclic antidepressants and falls, and the effect of age on this association was studied.<h4>Results</h4>A total of 192 patients tested positive for benzodiazepines, opioids and tricyclic antidepressants, with same-level falls being the most frequent mechanism of injury in this group (40.1%), with an odds ratio of 1.96 (1.40-2.75), p < 0.001. Once other covariates were introduced, this association was not observed, leaving only age, gender (woman) and, to a lesser extent, sensory conditions as variables associated with falls. Age acted as an effect modifier between benzodiazepines, opioids and tricyclic antidepressants and falls, with significant effect sizes starting at 51.9 years of age.<h4>Conclusions</h4>The association between the consumption of benzodiazepines, opioids and tricyclic antidepressants and falls in patients admitted for trauma is conditioned by other confounding variables, with age being the most influential confounding variable.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227696&type=printable |
| spellingShingle | Sergio Cordovilla-Guardia Tania Bautista Molina Cristina Franco-Antonio Esperanza Santano-Mogena Raquel Vilar-López Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age. PLoS ONE |
| title | Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age. |
| title_full | Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age. |
| title_fullStr | Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age. |
| title_full_unstemmed | Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age. |
| title_short | Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age. |
| title_sort | association of benzodiazepines opioids and tricyclic antidepressants use and falls in trauma patients conditional effect of age |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227696&type=printable |
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