Key motor and non-motor features in early dementia with Lewy bodies
ObjectiveThe objective of our study was to characterize early-stage dementia with Lewy bodies (DLB) focusing on motor and non-motor symptoms.MethodsThis cross-sectional study prospectively included newly diagnosed DLB patients within 3 years of cognitive symptom onset. Comparisons were made with ind...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1555175/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850226508951453696 |
|---|---|
| author | Anna Planas-Ballvé Anna Planas-Ballvé José Rios Lourdes Ispierto Mireia Gea Laia Grau Marta Jiménez Cynthia Cáceres Sílvia Martínez Katrin Beyer Ramiro Álvarez Pau Pastor Dolores Vilas Dolores Vilas |
| author_facet | Anna Planas-Ballvé Anna Planas-Ballvé José Rios Lourdes Ispierto Mireia Gea Laia Grau Marta Jiménez Cynthia Cáceres Sílvia Martínez Katrin Beyer Ramiro Álvarez Pau Pastor Dolores Vilas Dolores Vilas |
| author_sort | Anna Planas-Ballvé |
| collection | DOAJ |
| description | ObjectiveThe objective of our study was to characterize early-stage dementia with Lewy bodies (DLB) focusing on motor and non-motor symptoms.MethodsThis cross-sectional study prospectively included newly diagnosed DLB patients within 3 years of cognitive symptom onset. Comparisons were made with individuals with Parkinson’s disease (PD), Alzheimer’s disease (AD), and controls. Demographic and clinical data were collected, and motor and non-motor symptoms were assessed using structured interviews and validated scales and questionnaires.ResultsA total of 107 participants were included (23 DLB, 27 PD, 26 AD, and 31 controls). DLB patients (median age 75 years, median disease duration since diagnosis 2 months) commonly reported motor symptoms, including gait disturbances (91.3%), tremor (73.9%), and bradykinesia (87%), with tremor being predominantly unilateral (76.5%) and action-type (52.9%). The most frequent motor subtype was akinetic-rigid (52.2%). Motor symptoms were similar to PD, except for more frequent falls (34.8% vs. 11.1%, p = 0.044) and gait disturbances in DLB patients (91.3% vs. 63%, p = 0.019). Non-motor symptoms, particularly visual hallucinations and neuropsychiatric symptoms were more prevalent in DLB than in PD, while sleep and autonomic symptoms were similar. An abnormal orthostatic test was more frequent in DLB than in PD (45.5% vs. 11.5%, p < 0.008). Compared to AD, all non-motor symptoms were significantly more frequent in DLB. Finally, DLB patients had lower functional independence and quality of life than both PD and AD (p < 0.0001).ConclusionEarly-stage DLB closely resembles PD in motor symptoms but has more neuropsychiatric non-motor symptoms compared to PD and overall non-motor symptoms than AD. |
| format | Article |
| id | doaj-art-2a46b4fa2e444c4f80aa9d90b6cda66b |
| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-2a46b4fa2e444c4f80aa9d90b6cda66b2025-08-20T02:05:03ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-03-011610.3389/fneur.2025.15551751555175Key motor and non-motor features in early dementia with Lewy bodiesAnna Planas-Ballvé0Anna Planas-Ballvé1José Rios2Lourdes Ispierto3Mireia Gea4Laia Grau5Marta Jiménez6Cynthia Cáceres7Sílvia Martínez8Katrin Beyer9Ramiro Álvarez10Pau Pastor11Dolores Vilas12Dolores Vilas13Movement Disorders Unit, Neurology Department, Complex Hospitalari Moisès Broggi, Barcelona, SpainMovement Disorders Unit, Neurology Department, Hospital Universitari Germans Trias i Pujol, Barcelona, SpainDepartment of Clinical Pharmacology, Hospital Clinic, IDIBAPS, Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, SpainMovement Disorders Unit, Neurology Department, Hospital Universitari Germans Trias i Pujol, Barcelona, SpainMovement Disorders Unit, Neurology Department, Hospital Universitari Germans Trias i Pujol, Barcelona, SpainEpilepsy Unit, Neurology Department, Hospital Universitari Germans Trias i Pujol, Badalona, SpainEpilepsy Unit, Neurology Department, Hospital Universitari Germans Trias i Pujol, Badalona, SpainNeuropsychology Unit, Neurology Department, Hospital Universitari Germans Trias i Pujol, Badalona, SpainNeuropsychology Unit, Neurology Department, Hospital Universitari Germans Trias i Pujol, Badalona, SpainDepartment of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, SpainMovement Disorders Unit, Neurology Department, Hospital Universitari Germans Trias i Pujol, Barcelona, SpainMovement Disorders Unit, Neurology Department, Hospital Universitari Germans Trias i Pujol, Barcelona, SpainMovement Disorders Unit, Neurology Department, Hospital Universitari Germans Trias i Pujol, Barcelona, SpainDepartment of Medicine, Universitat Autònoma de Barcelona, Barcelona, SpainObjectiveThe objective of our study was to characterize early-stage dementia with Lewy bodies (DLB) focusing on motor and non-motor symptoms.MethodsThis cross-sectional study prospectively included newly diagnosed DLB patients within 3 years of cognitive symptom onset. Comparisons were made with individuals with Parkinson’s disease (PD), Alzheimer’s disease (AD), and controls. Demographic and clinical data were collected, and motor and non-motor symptoms were assessed using structured interviews and validated scales and questionnaires.ResultsA total of 107 participants were included (23 DLB, 27 PD, 26 AD, and 31 controls). DLB patients (median age 75 years, median disease duration since diagnosis 2 months) commonly reported motor symptoms, including gait disturbances (91.3%), tremor (73.9%), and bradykinesia (87%), with tremor being predominantly unilateral (76.5%) and action-type (52.9%). The most frequent motor subtype was akinetic-rigid (52.2%). Motor symptoms were similar to PD, except for more frequent falls (34.8% vs. 11.1%, p = 0.044) and gait disturbances in DLB patients (91.3% vs. 63%, p = 0.019). Non-motor symptoms, particularly visual hallucinations and neuropsychiatric symptoms were more prevalent in DLB than in PD, while sleep and autonomic symptoms were similar. An abnormal orthostatic test was more frequent in DLB than in PD (45.5% vs. 11.5%, p < 0.008). Compared to AD, all non-motor symptoms were significantly more frequent in DLB. Finally, DLB patients had lower functional independence and quality of life than both PD and AD (p < 0.0001).ConclusionEarly-stage DLB closely resembles PD in motor symptoms but has more neuropsychiatric non-motor symptoms compared to PD and overall non-motor symptoms than AD.https://www.frontiersin.org/articles/10.3389/fneur.2025.1555175/fulldementia with Lewy bodiesmotor symptomsnon-motor symptomsneurodegenerative diseasesdifferential diagnosis |
| spellingShingle | Anna Planas-Ballvé Anna Planas-Ballvé José Rios Lourdes Ispierto Mireia Gea Laia Grau Marta Jiménez Cynthia Cáceres Sílvia Martínez Katrin Beyer Ramiro Álvarez Pau Pastor Dolores Vilas Dolores Vilas Key motor and non-motor features in early dementia with Lewy bodies Frontiers in Neurology dementia with Lewy bodies motor symptoms non-motor symptoms neurodegenerative diseases differential diagnosis |
| title | Key motor and non-motor features in early dementia with Lewy bodies |
| title_full | Key motor and non-motor features in early dementia with Lewy bodies |
| title_fullStr | Key motor and non-motor features in early dementia with Lewy bodies |
| title_full_unstemmed | Key motor and non-motor features in early dementia with Lewy bodies |
| title_short | Key motor and non-motor features in early dementia with Lewy bodies |
| title_sort | key motor and non motor features in early dementia with lewy bodies |
| topic | dementia with Lewy bodies motor symptoms non-motor symptoms neurodegenerative diseases differential diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1555175/full |
| work_keys_str_mv | AT annaplanasballve keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT annaplanasballve keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT joserios keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT lourdesispierto keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT mireiagea keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT laiagrau keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT martajimenez keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT cynthiacaceres keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT silviamartinez keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT katrinbeyer keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT ramiroalvarez keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT paupastor keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT doloresvilas keymotorandnonmotorfeaturesinearlydementiawithlewybodies AT doloresvilas keymotorandnonmotorfeaturesinearlydementiawithlewybodies |