Incidence and Implications of Culture-Positive Corneoscleral Rims in Corneal Transplantation
Zuheer Meeraalam,1 Shaker O Alreshidi,2 Hani B ALBalawi,3 Naif M Alali,3 Faris Hashem,3 Omar M Kirat4 1Ophthalmology Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; 2Ophthalmology Division, Department of Surgical Specialties, College of Medicine, Majmaah University, Majmaah, S...
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Dove Medical Press
2025-02-01
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| Series: | Infection and Drug Resistance |
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| author | Meeraalam Z Alreshidi SO ALBalawi HB Alali NM Hashem F Kirat OM |
| author_facet | Meeraalam Z Alreshidi SO ALBalawi HB Alali NM Hashem F Kirat OM |
| author_sort | Meeraalam Z |
| collection | DOAJ |
| description | Zuheer Meeraalam,1 Shaker O Alreshidi,2 Hani B ALBalawi,3 Naif M Alali,3 Faris Hashem,3 Omar M Kirat4 1Ophthalmology Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; 2Ophthalmology Division, Department of Surgical Specialties, College of Medicine, Majmaah University, Majmaah, Saudi Arabia; 3Division of Ophthalmology, Department of Surgery, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia; 4Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi ArabiaCorrespondence: Hani B ALBalawi, Division of Ophthalmology, Department of Surgery, Faculty of Medicine, University of Tabuk, Tabuk, 71491, Saudi Arabia, Email hb.albalawi@ut.edu.saBackground: Corneal transplantation is a critical procedure for restoring vision affected by different corneal pathologies. However, postoperative infections threaten graft survival, particularly microbial keratitis and endophthalmitis.Objective: This study aims to evaluate the incidence of culture-positive corneoscleral rims (CPCR) among transplanted corneas at a tertiary eye hospital and explore its association with death-preservation and preservation-surgery times.Methods: A retrospective analysis of keratoplasty surgeries performed in 2015 was conducted, involving 603 cases meeting the study criteria.Results: The incidence of CPCR was found to be 4.6%, predominantly bacterial (68%), with Methicillin-resistant Staphylococcus epidermidis (MRSE) being the most common isolate, followed by fungal (32%) species, notably Candida. However, none of the cases developed subsequent keratitis or endophthalmitis post-transplantation. Statistical analysis revealed no significant association between CPCR occurrence and death-preservation or preservation-surgery times.Conclusion: The study underscores the reduced impact of contaminated CPCR on graft outcomes, advocating for targeted fungal culturing, intraoperative practices to mitigate post-transplant infections, and maintaining current prophylactic antibiotic regimens, such as optisolGS ™, which contains streptomycin and gentamicin.Keywords: corneal transplant, keratitis, endophthalmitis, infection, bacterial keratitis |
| format | Article |
| id | doaj-art-2a453748e562485f9342285f7a592d17 |
| institution | Kabale University |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj-art-2a453748e562485f9342285f7a592d172025-02-11T17:30:55ZengDove Medical PressInfection and Drug Resistance1178-69732025-02-01Volume 18847853100102Incidence and Implications of Culture-Positive Corneoscleral Rims in Corneal TransplantationMeeraalam ZAlreshidi SOALBalawi HBAlali NMHashem FKirat OMZuheer Meeraalam,1 Shaker O Alreshidi,2 Hani B ALBalawi,3 Naif M Alali,3 Faris Hashem,3 Omar M Kirat4 1Ophthalmology Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; 2Ophthalmology Division, Department of Surgical Specialties, College of Medicine, Majmaah University, Majmaah, Saudi Arabia; 3Division of Ophthalmology, Department of Surgery, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia; 4Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi ArabiaCorrespondence: Hani B ALBalawi, Division of Ophthalmology, Department of Surgery, Faculty of Medicine, University of Tabuk, Tabuk, 71491, Saudi Arabia, Email hb.albalawi@ut.edu.saBackground: Corneal transplantation is a critical procedure for restoring vision affected by different corneal pathologies. However, postoperative infections threaten graft survival, particularly microbial keratitis and endophthalmitis.Objective: This study aims to evaluate the incidence of culture-positive corneoscleral rims (CPCR) among transplanted corneas at a tertiary eye hospital and explore its association with death-preservation and preservation-surgery times.Methods: A retrospective analysis of keratoplasty surgeries performed in 2015 was conducted, involving 603 cases meeting the study criteria.Results: The incidence of CPCR was found to be 4.6%, predominantly bacterial (68%), with Methicillin-resistant Staphylococcus epidermidis (MRSE) being the most common isolate, followed by fungal (32%) species, notably Candida. However, none of the cases developed subsequent keratitis or endophthalmitis post-transplantation. Statistical analysis revealed no significant association between CPCR occurrence and death-preservation or preservation-surgery times.Conclusion: The study underscores the reduced impact of contaminated CPCR on graft outcomes, advocating for targeted fungal culturing, intraoperative practices to mitigate post-transplant infections, and maintaining current prophylactic antibiotic regimens, such as optisolGS ™, which contains streptomycin and gentamicin.Keywords: corneal transplant, keratitis, endophthalmitis, infection, bacterial keratitishttps://www.dovepress.com/incidence-and-implications-of-culture-positive-corneoscleral-rims-in-c-peer-reviewed-fulltext-article-IDRcorneal transplantkeratitisendophthalmitisinfectionbacterial keratitis. |
| spellingShingle | Meeraalam Z Alreshidi SO ALBalawi HB Alali NM Hashem F Kirat OM Incidence and Implications of Culture-Positive Corneoscleral Rims in Corneal Transplantation Infection and Drug Resistance corneal transplant keratitis endophthalmitis infection bacterial keratitis. |
| title | Incidence and Implications of Culture-Positive Corneoscleral Rims in Corneal Transplantation |
| title_full | Incidence and Implications of Culture-Positive Corneoscleral Rims in Corneal Transplantation |
| title_fullStr | Incidence and Implications of Culture-Positive Corneoscleral Rims in Corneal Transplantation |
| title_full_unstemmed | Incidence and Implications of Culture-Positive Corneoscleral Rims in Corneal Transplantation |
| title_short | Incidence and Implications of Culture-Positive Corneoscleral Rims in Corneal Transplantation |
| title_sort | incidence and implications of culture positive corneoscleral rims in corneal transplantation |
| topic | corneal transplant keratitis endophthalmitis infection bacterial keratitis. |
| url | https://www.dovepress.com/incidence-and-implications-of-culture-positive-corneoscleral-rims-in-c-peer-reviewed-fulltext-article-IDR |
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