Glioblastoma with markedly reduced contrast enhancement after corticosteroid administration: Increased density and reduced diffusion capability are noteworthy

Glioblastoma with markedly reduced contrast enhancement after corticosteroid administration: Increased density and reduced diffusion capability are noteworthy

Corticosteroids are widely used to manage peritumoral edema and associated neurological deficits in patients with brain tumors. We describe the case of a 71-year-old male patient with glioblastoma in which contrast enhancement decreased on radiographic imaging following corticosteroid administration...

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Main Authors: Daiki Toda, MD, Satoshi Nakajima, MD, PhD, Yasutaka Fushimi, MD, PhD, Takaaki Kitano, MD, Masahiro Tanji, MD, PhD, Yohei Mineharu, MD, PhD, Yasuhide Takeuchi, MD, PhD, Hironori Haga, MD, PhD, Yoshiki Arakawa, MD, PhD, Yuji Nakamoto, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Radiology Case Reports
Subjects:
Glioblastoma
Corticosteroid
Contrast enhancement
Density
Diffusion capability
Online Access:http://www.sciencedirect.com/science/article/pii/S1930043325002626
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Summary:Corticosteroids are widely used to manage peritumoral edema and associated neurological deficits in patients with brain tumors. We describe the case of a 71-year-old male patient with glioblastoma in which contrast enhancement decreased on radiographic imaging following corticosteroid administration, which has been reported previously in only 9 cases. This report aims to discuss radiographic changes in glioblastoma (density on computed tomography and diffusion capability on diffusion-weighted magnetic resonance imaging, in addition to enhancement on contrast-enhanced T1-weighted magnetic resonance imaging) following steroid administration and also following steroid discontinuation.
ISSN:1930-0433

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