Association between serum Klotho and all-cause mortality in postmenopausal women: a prospective population-based cohort analysis from NHANES 2007–2016
This study investigated the association between serum Klotho levels and all-cause mortality in postmenopausal women. Utilizing data from 3,448 postmenopausal women in the US National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016, multivariable-adjusted weighted Cox proportional...
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| Format: | Article |
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Taylor & Francis Group
2025-12-01
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| Series: | Gynecological Endocrinology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09513590.2025.2512831 |
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| author | Bo Zhang Ye Zhang Tao Wang Xing Gao |
| author_facet | Bo Zhang Ye Zhang Tao Wang Xing Gao |
| author_sort | Bo Zhang |
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| description | This study investigated the association between serum Klotho levels and all-cause mortality in postmenopausal women. Utilizing data from 3,448 postmenopausal women in the US National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016, multivariable-adjusted weighted Cox proportional hazards models were employed. Over a median follow-up of 106 months, 449 deaths occurred. Compared to the second tertile (T 2, 707.3-936.5 pg/mL), the adjusted HRs for all-cause mortality were 1.44 (95% CI: 1.11-1.86, p=0.005) for the first tertile (T 1, <707.3 pg/mL) and 1.31 (95% CI: 0.94-1.83, p=0.112) for the third tertile (T 3, ≥936.5 pg/mL). The restricted cubic spline model revealed an L-shaped association between serum Klotho levels and all-cause mortality, with an inflection point at an ln-transformed Klotho level of 6.638 pg/mL. Our findings suggest an L-shaped relationship between ln-transformed serum Klotho levels and all-cause mortality in postmenopausal women. Further research is needed to validate these results and elucidate the underlying mechanisms. . |
| format | Article |
| id | doaj-art-2a435a197a6b4556b87aa9ee773cb1b8 |
| institution | OA Journals |
| issn | 0951-3590 1473-0766 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
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| series | Gynecological Endocrinology |
| spelling | doaj-art-2a435a197a6b4556b87aa9ee773cb1b82025-08-20T02:33:39ZengTaylor & Francis GroupGynecological Endocrinology0951-35901473-07662025-12-0141110.1080/09513590.2025.2512831Association between serum Klotho and all-cause mortality in postmenopausal women: a prospective population-based cohort analysis from NHANES 2007–2016Bo Zhang0Ye Zhang1Tao Wang2Xing Gao3Department of Pharmacy, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaGraduate School, Hebei North University, Zhangjiakou, ChinaDepartment of Pharmacy, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Pharmacy, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaThis study investigated the association between serum Klotho levels and all-cause mortality in postmenopausal women. Utilizing data from 3,448 postmenopausal women in the US National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016, multivariable-adjusted weighted Cox proportional hazards models were employed. Over a median follow-up of 106 months, 449 deaths occurred. Compared to the second tertile (T 2, 707.3-936.5 pg/mL), the adjusted HRs for all-cause mortality were 1.44 (95% CI: 1.11-1.86, p=0.005) for the first tertile (T 1, <707.3 pg/mL) and 1.31 (95% CI: 0.94-1.83, p=0.112) for the third tertile (T 3, ≥936.5 pg/mL). The restricted cubic spline model revealed an L-shaped association between serum Klotho levels and all-cause mortality, with an inflection point at an ln-transformed Klotho level of 6.638 pg/mL. Our findings suggest an L-shaped relationship between ln-transformed serum Klotho levels and all-cause mortality in postmenopausal women. Further research is needed to validate these results and elucidate the underlying mechanisms. .https://www.tandfonline.com/doi/10.1080/09513590.2025.2512831Klothoall-cause mortalitypostmenopausal womenNHANESL-shaped association |
| spellingShingle | Bo Zhang Ye Zhang Tao Wang Xing Gao Association between serum Klotho and all-cause mortality in postmenopausal women: a prospective population-based cohort analysis from NHANES 2007–2016 Gynecological Endocrinology Klotho all-cause mortality postmenopausal women NHANES L-shaped association |
| title | Association between serum Klotho and all-cause mortality in postmenopausal women: a prospective population-based cohort analysis from NHANES 2007–2016 |
| title_full | Association between serum Klotho and all-cause mortality in postmenopausal women: a prospective population-based cohort analysis from NHANES 2007–2016 |
| title_fullStr | Association between serum Klotho and all-cause mortality in postmenopausal women: a prospective population-based cohort analysis from NHANES 2007–2016 |
| title_full_unstemmed | Association between serum Klotho and all-cause mortality in postmenopausal women: a prospective population-based cohort analysis from NHANES 2007–2016 |
| title_short | Association between serum Klotho and all-cause mortality in postmenopausal women: a prospective population-based cohort analysis from NHANES 2007–2016 |
| title_sort | association between serum klotho and all cause mortality in postmenopausal women a prospective population based cohort analysis from nhanes 2007 2016 |
| topic | Klotho all-cause mortality postmenopausal women NHANES L-shaped association |
| url | https://www.tandfonline.com/doi/10.1080/09513590.2025.2512831 |
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