Peripheral blood mitochondrial DNA copy number as a predictor of steatotic liver disease development: insights from epidemiological and experimental studies

Peripheral blood mitochondrial DNA copy number as a predictor of steatotic liver disease development: insights from epidemiological and experimental studies

Background: Mitochondria, which harbor their own genome (mtDNA), have attracted attention due to the potential of mtDNA copy number (mtDNA-CN) as an indicator of mitochondrial dysfunction. Although mtDNA-CN has been proposed as a simple and accessible biomarker for metabolic disorders such as metabo...

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Main Authors: Genki Mizuno, Atsushi Teshigawara, Hiroya Yamada, Eiji Munetsuna, Yoshiki Tsuboi, Yuji Hattori, Mirai Yamazaki, Yoshitaka Ando, Itsuki Kageyama, Takuya Wakasugi, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Ryosuke Fujii, Hiroaki Ishikawa, Nobutaka Ohgami, Koji Ohashi, Koji Suzuki
Format: Article
Language:English
Published: Komiyama Printing Co. Ltd 2025-05-01
Series:Environmental Health and Preventive Medicine
Subjects:
mitochondria
mitochondrial dna-copy number
steatotic liver disease
peripheral blood
predictive marker
Online Access:https://www.jstage.jst.go.jp/article/ehpm/30/0/30_25-00025/_html/-char/en
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