Nomogram to predict live birth in infertile women with adenomyosis undergoing IVF/ICSI treatment: a retrospective cohort study
PurposeThe study aimed to develop a nomogram to predict live birth outcomes in infertile women with adenomyosis undergoing IVF/ICSI treatment.Materials and methodsData were collected from the Center for Reproductive Medicine, Shandong University, between January 2016 and December 2020. This study in...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1473923/full |
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| author | Zhongyuan Li Wei Chen Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Li Ge Wenting Wang Ping Zhang |
| author_facet | Zhongyuan Li Wei Chen Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Li Ge Wenting Wang Ping Zhang |
| author_sort | Zhongyuan Li |
| collection | DOAJ |
| description | PurposeThe study aimed to develop a nomogram to predict live birth outcomes in infertile women with adenomyosis undergoing IVF/ICSI treatment.Materials and methodsData were collected from the Center for Reproductive Medicine, Shandong University, between January 2016 and December 2020. This study included 222 fresh embryo transfer (ET) cycles and 266 frozen embryo transfer (FET) cycles. Patients were divided into a modeling cohort and a validation cohort. In the modeling cohort, multivariable logistic regression was used to generate the predictive model and construct the nomogram. The predictive model was subsequently validated and calibrated.ResultsIn total, 249 patients (51.0%) achieved clinical pregnancy, and 165 patients (33.8%) had a live birth. Predictive variables in the final model included mean initial uterine diameter, age, body mass index (BMI), type of infertility (primary or secondary), stage of transferred embryo, endometrial thickness, number of embryos transferred, and pregnancy type. The area under the receiver operating characteristic (ROC) curve for the final prediction model was 0.915 (95% confidence interval [CI]: 88.6%–94.3%) in the modeling cohort and 0.940 (95% CI: 90.3%–97.6%) in the validation cohort. Calibration curves and the Hosmer–Lemeshow (H–L) test demonstrated excellent consistency between predicted and actual live birth outcomes.ConclusionsThis study established a well-calibrated predictive model capable of accurately forecasting live birth outcomes in infertile women with adenomyosis undergoing IVF/ICSI treatment. |
| format | Article |
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| language | English |
| publishDate | 2025-07-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-2a42144a70ed4ce3a794b9d5bfc4ef852025-08-20T03:51:19ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.14739231473923Nomogram to predict live birth in infertile women with adenomyosis undergoing IVF/ICSI treatment: a retrospective cohort studyZhongyuan Li0Wei Chen1Xiaohan Sun2Xiaohan Sun3Xiaohan Sun4Xiaohan Sun5Xiaohan Sun6Xiaohan Sun7Xiaohan Sun8Xiaohan Sun9Xiaohan Sun10Xueqing Zhao11Xueqing Zhao12Xueqing Zhao13Xueqing Zhao14Xueqing Zhao15Xueqing Zhao16Xueqing Zhao17Xueqing Zhao18Xueqing Zhao19Jingmei Hu20Jingmei Hu21Jingmei Hu22Jingmei Hu23Jingmei Hu24Jingmei Hu25Jingmei Hu26Jingmei Hu27Jingmei Hu28Li Ge29Wenting Wang30Ping Zhang31Center for Reproductive Medicine, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaSchool of Radiology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’an, Shandong, ChinaCenter for Reproductive Medicine, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, ChinaState Key Laboratory of Reproductive Medicine and Offspring Health, Shandong University, Jinan, Shandong, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, ChinaKey laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, ChinaShandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, ChinaShandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China0Research Unit of Gametogenesis and Health of Assisted Reproductive Technology (ART)-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, ChinaCenter for Reproductive Medicine, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, ChinaState Key Laboratory of Reproductive Medicine and Offspring Health, Shandong University, Jinan, Shandong, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, ChinaKey laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, ChinaShandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, ChinaShandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China0Research Unit of Gametogenesis and Health of Assisted Reproductive Technology (ART)-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, ChinaCenter for Reproductive Medicine, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, ChinaState Key Laboratory of Reproductive Medicine and Offspring Health, Shandong University, Jinan, Shandong, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, ChinaKey laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, ChinaShandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China0Research Unit of Gametogenesis and Health of Assisted Reproductive Technology (ART)-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China1Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaCenter for Reproductive Medicine, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaCenter for Reproductive Medicine, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China2Gynecologic Department, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaPurposeThe study aimed to develop a nomogram to predict live birth outcomes in infertile women with adenomyosis undergoing IVF/ICSI treatment.Materials and methodsData were collected from the Center for Reproductive Medicine, Shandong University, between January 2016 and December 2020. This study included 222 fresh embryo transfer (ET) cycles and 266 frozen embryo transfer (FET) cycles. Patients were divided into a modeling cohort and a validation cohort. In the modeling cohort, multivariable logistic regression was used to generate the predictive model and construct the nomogram. The predictive model was subsequently validated and calibrated.ResultsIn total, 249 patients (51.0%) achieved clinical pregnancy, and 165 patients (33.8%) had a live birth. Predictive variables in the final model included mean initial uterine diameter, age, body mass index (BMI), type of infertility (primary or secondary), stage of transferred embryo, endometrial thickness, number of embryos transferred, and pregnancy type. The area under the receiver operating characteristic (ROC) curve for the final prediction model was 0.915 (95% confidence interval [CI]: 88.6%–94.3%) in the modeling cohort and 0.940 (95% CI: 90.3%–97.6%) in the validation cohort. Calibration curves and the Hosmer–Lemeshow (H–L) test demonstrated excellent consistency between predicted and actual live birth outcomes.ConclusionsThis study established a well-calibrated predictive model capable of accurately forecasting live birth outcomes in infertile women with adenomyosis undergoing IVF/ICSI treatment.https://www.frontiersin.org/articles/10.3389/fendo.2025.1473923/fulladenomyosislive birthnomogramin vitro fertilization (IVF)intracytoplasmic sperm injection (ICSI) |
| spellingShingle | Zhongyuan Li Wei Chen Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xiaohan Sun Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Xueqing Zhao Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Jingmei Hu Li Ge Wenting Wang Ping Zhang Nomogram to predict live birth in infertile women with adenomyosis undergoing IVF/ICSI treatment: a retrospective cohort study Frontiers in Endocrinology adenomyosis live birth nomogram in vitro fertilization (IVF) intracytoplasmic sperm injection (ICSI) |
| title | Nomogram to predict live birth in infertile women with adenomyosis undergoing IVF/ICSI treatment: a retrospective cohort study |
| title_full | Nomogram to predict live birth in infertile women with adenomyosis undergoing IVF/ICSI treatment: a retrospective cohort study |
| title_fullStr | Nomogram to predict live birth in infertile women with adenomyosis undergoing IVF/ICSI treatment: a retrospective cohort study |
| title_full_unstemmed | Nomogram to predict live birth in infertile women with adenomyosis undergoing IVF/ICSI treatment: a retrospective cohort study |
| title_short | Nomogram to predict live birth in infertile women with adenomyosis undergoing IVF/ICSI treatment: a retrospective cohort study |
| title_sort | nomogram to predict live birth in infertile women with adenomyosis undergoing ivf icsi treatment a retrospective cohort study |
| topic | adenomyosis live birth nomogram in vitro fertilization (IVF) intracytoplasmic sperm injection (ICSI) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1473923/full |
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