Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy
Abstract Medical interns are at high risk of acquiring Hepatitis B Virus (HBV) infection during their training. HBV vaccination is the most effective measure to reduce the global incidence of HBV. The duration of protection after HBV vaccination is still controversial. We aimed to determine the prev...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-00055-w |
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| author | Nesrine Fathi Hanafi Nashwa Naguib Omar Ghada Abdelwahed Ismail Amani Ali El-Kholy Ahmed ElShafei Sara AbdelAziz Essa |
| author_facet | Nesrine Fathi Hanafi Nashwa Naguib Omar Ghada Abdelwahed Ismail Amani Ali El-Kholy Ahmed ElShafei Sara AbdelAziz Essa |
| author_sort | Nesrine Fathi Hanafi |
| collection | DOAJ |
| description | Abstract Medical interns are at high risk of acquiring Hepatitis B Virus (HBV) infection during their training. HBV vaccination is the most effective measure to reduce the global incidence of HBV. The duration of protection after HBV vaccination is still controversial. We aimed to determine the prevalence of protective anti-HBs levels among medical interns who had received compulsory hepatitis B vaccination in infancy, and to assess the anamnestic response of those subjects with non-protective antibodies titers, to a booster dose of the vaccine. We conducted a cross-sectional study on 519 medical interns in 2022. We examined their immunization status and records. Blood samples were collected and qualitative testing of Hepatitis B surface antigen (HBsAg), and quantitative testing of Hepatitis B surface antibody (anti-HBs) were performed. For medical interns whose titers were ˂ 10 mIU/mL, a booster dose of the vaccine was given, followed by repeat testing of anti-HBs 2 months later. About 304 (58.6%) of the medical interns revealed titers higher than or equal 10 mIU/mL. About (44.93%) of male medical interns showed an immunity level below 10 mIU/mL. However, (43.91%) of female medical interns had an antibody titer of 100 mIU/mL or higher. All subjects who got a booster dose presented a titer level of 10 mIU/mL 2 months later. About (41.4%) of our medical interns enrolled in the study had anti-HBs titer ˂ 10 mIU/mL. This raises the importance of establishing a screening protocol and offering booster dose for those at risk to protect them against the high risk of infection. |
| format | Article |
| id | doaj-art-2a392a84ce7f43b5a80bfc353deac49e |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-2a392a84ce7f43b5a80bfc353deac49e2025-08-20T03:09:35ZengNature PortfolioScientific Reports2045-23222025-05-011511610.1038/s41598-025-00055-wAnti-HBs persistence and anamnestic response among medical interns vaccinated in infancyNesrine Fathi Hanafi0Nashwa Naguib Omar1Ghada Abdelwahed Ismail2Amani Ali El-Kholy3Ahmed ElShafei4Sara AbdelAziz Essa5Department of Medical Microbiology and Immunology, Faculty of Medicine, Alexandria UniversityDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams UniversityDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams UniversityDepartment of Clinical Pathology, Faculty of Medicine, Cairo UniversityModern University for Information and TechnologyDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Alexandria UniversityAbstract Medical interns are at high risk of acquiring Hepatitis B Virus (HBV) infection during their training. HBV vaccination is the most effective measure to reduce the global incidence of HBV. The duration of protection after HBV vaccination is still controversial. We aimed to determine the prevalence of protective anti-HBs levels among medical interns who had received compulsory hepatitis B vaccination in infancy, and to assess the anamnestic response of those subjects with non-protective antibodies titers, to a booster dose of the vaccine. We conducted a cross-sectional study on 519 medical interns in 2022. We examined their immunization status and records. Blood samples were collected and qualitative testing of Hepatitis B surface antigen (HBsAg), and quantitative testing of Hepatitis B surface antibody (anti-HBs) were performed. For medical interns whose titers were ˂ 10 mIU/mL, a booster dose of the vaccine was given, followed by repeat testing of anti-HBs 2 months later. About 304 (58.6%) of the medical interns revealed titers higher than or equal 10 mIU/mL. About (44.93%) of male medical interns showed an immunity level below 10 mIU/mL. However, (43.91%) of female medical interns had an antibody titer of 100 mIU/mL or higher. All subjects who got a booster dose presented a titer level of 10 mIU/mL 2 months later. About (41.4%) of our medical interns enrolled in the study had anti-HBs titer ˂ 10 mIU/mL. This raises the importance of establishing a screening protocol and offering booster dose for those at risk to protect them against the high risk of infection.https://doi.org/10.1038/s41598-025-00055-wHepatitis BVaccineImmunizationBoosterEgypt |
| spellingShingle | Nesrine Fathi Hanafi Nashwa Naguib Omar Ghada Abdelwahed Ismail Amani Ali El-Kholy Ahmed ElShafei Sara AbdelAziz Essa Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy Scientific Reports Hepatitis B Vaccine Immunization Booster Egypt |
| title | Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy |
| title_full | Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy |
| title_fullStr | Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy |
| title_full_unstemmed | Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy |
| title_short | Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy |
| title_sort | anti hbs persistence and anamnestic response among medical interns vaccinated in infancy |
| topic | Hepatitis B Vaccine Immunization Booster Egypt |
| url | https://doi.org/10.1038/s41598-025-00055-w |
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