Blackleg in inadequately immunized calves and their recovery following antibiotic therapy
Introduction: There is consensus regarding the importance of blackleg vaccination as a preventive measure, and proper immunization protocols are available. However, few studies have evaluated the effectiveness of vaccine protection against Clostridium chauvoei and the treatment of the disease in ca...
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The Journal of Infection in Developing Countries
2020-07-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/12613 |
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| author | Carolina C Guizelini Otávio AC Silvestre Carlos AN Ramos Danilo C Gomes Ricardo Antonio A Lemos |
| author_facet | Carolina C Guizelini Otávio AC Silvestre Carlos AN Ramos Danilo C Gomes Ricardo Antonio A Lemos |
| author_sort | Carolina C Guizelini |
| collection | DOAJ |
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Introduction: There is consensus regarding the importance of blackleg vaccination as a preventive measure, and proper immunization protocols are available. However, few studies have evaluated the effectiveness of vaccine protection against Clostridium chauvoei and the treatment of the disease in calves exhibiting early or advanced clinical courses. This study describes twelve blackleg cases in unvaccinated calves and in calves that received a single dose of the vaccine. It also reports the recovery of some calves after antibiotic therapy.
Methodology: Two necropsies of cattle dead from blackleg were performed. Fragments of skeletal muscle from these two cattle were immersed in paraffin for multiplex polymerase chain reaction (PCR) analysis.
Results: Twelve calves up to nine months of age developed signs of blackleg and eight died. Ten of those 9-month-old calves had received only the first dose of a blackleg vaccine at 4 months of age, but no booster. The last two affected calves belonged to a herd that had never been vaccinated. Four out of five calves treated with penicillin for 6-7 days recovered from the disease. The diagnosis of blackleg was based on necropsy, histopathological findings and detection of C. chauvoei in skeletal muscle samples of two necropsied calves using PCR.
Conclusions: The occurrence of cases only in calves that did not receive a booster dose or were not vaccinated indicated that the vaccine used was effective when performed as recommended by the manufacturer. However, neglecting the booster resulted in casualties due to blackleg.
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| format | Article |
| id | doaj-art-2a30149a795f4787ad6bd6db871ba9d3 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2020-07-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-2a30149a795f4787ad6bd6db871ba9d32025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802020-07-01140710.3855/jidc.12613Blackleg in inadequately immunized calves and their recovery following antibiotic therapyCarolina C Guizelini0Otávio AC Silvestre1Carlos AN Ramos2Danilo C Gomes3Ricardo Antonio A Lemos4Faculdade de Medicina Veterinária e Zootecnia (FAMEZ), Universidade Federal de Mato Grosso do Sul (UFMS), MS, Campo Grande, BrazilLaboratório de Anatomia Patológica, Faculdade de Medicina Veterinária e Zootecnia (FAMEZ), Universidade Federal de Mato Grosso do Sul (UFMS), MS, Campo Grande, BrazilLaboratório de Biologia Molecular, Faculdade de Medicina Veterinária e Zootecnia (FAMEZ), Universidade Federal de Mato Grosso do Sul (UFMS), MS, Campo Grande, BrazilLaboratório de Anatomia Patológica, Faculdade de Medicina Veterinária e Zootecnia (FAMEZ), Universidade Federal de Mato Grosso do Sul (UFMS), MS, Campo Grande, BrazilLaboratório de Anatomia Patológica, Faculdade de Medicina Veterinária e Zootecnia (FAMEZ), Universidade Federal de Mato Grosso do Sul (UFMS), MS, Campo Grande, Brazil Introduction: There is consensus regarding the importance of blackleg vaccination as a preventive measure, and proper immunization protocols are available. However, few studies have evaluated the effectiveness of vaccine protection against Clostridium chauvoei and the treatment of the disease in calves exhibiting early or advanced clinical courses. This study describes twelve blackleg cases in unvaccinated calves and in calves that received a single dose of the vaccine. It also reports the recovery of some calves after antibiotic therapy. Methodology: Two necropsies of cattle dead from blackleg were performed. Fragments of skeletal muscle from these two cattle were immersed in paraffin for multiplex polymerase chain reaction (PCR) analysis. Results: Twelve calves up to nine months of age developed signs of blackleg and eight died. Ten of those 9-month-old calves had received only the first dose of a blackleg vaccine at 4 months of age, but no booster. The last two affected calves belonged to a herd that had never been vaccinated. Four out of five calves treated with penicillin for 6-7 days recovered from the disease. The diagnosis of blackleg was based on necropsy, histopathological findings and detection of C. chauvoei in skeletal muscle samples of two necropsied calves using PCR. Conclusions: The occurrence of cases only in calves that did not receive a booster dose or were not vaccinated indicated that the vaccine used was effective when performed as recommended by the manufacturer. However, neglecting the booster resulted in casualties due to blackleg. https://jidc.org/index.php/journal/article/view/12613Clostridium chauvoeicattle diseaseclostridial diseaseblacklegimmunization |
| spellingShingle | Carolina C Guizelini Otávio AC Silvestre Carlos AN Ramos Danilo C Gomes Ricardo Antonio A Lemos Blackleg in inadequately immunized calves and their recovery following antibiotic therapy Journal of Infection in Developing Countries Clostridium chauvoei cattle disease clostridial disease blackleg immunization |
| title | Blackleg in inadequately immunized calves and their recovery following antibiotic therapy |
| title_full | Blackleg in inadequately immunized calves and their recovery following antibiotic therapy |
| title_fullStr | Blackleg in inadequately immunized calves and their recovery following antibiotic therapy |
| title_full_unstemmed | Blackleg in inadequately immunized calves and their recovery following antibiotic therapy |
| title_short | Blackleg in inadequately immunized calves and their recovery following antibiotic therapy |
| title_sort | blackleg in inadequately immunized calves and their recovery following antibiotic therapy |
| topic | Clostridium chauvoei cattle disease clostridial disease blackleg immunization |
| url | https://jidc.org/index.php/journal/article/view/12613 |
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