Potentially Biodynamic Tetraaza Macrocycles and their Manganese Complexes: Antiandrogen, Antimicrobial and PDI Studies
Fourteen to eighteen membered tetraazamacrocyclic ligands N4TTD1–N4TTD4 have been synthesized by the condensation of aliphatic diamines. H2N–(CH2)y–NH2 (y = 2 or 3) and dicarboxylic acids, HOOC- (CH2)x–COOH (x = 1 or 2) in the presence of condensing reagents dicyclohexylcarbodiimide (DCHC) and 4- di...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
|
| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/BCA.2005.161 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850229878092201984 |
|---|---|
| author | Ashu Chaudhary Anita Phor R. V. Singh |
| author_facet | Ashu Chaudhary Anita Phor R. V. Singh |
| author_sort | Ashu Chaudhary |
| collection | DOAJ |
| description | Fourteen to eighteen membered tetraazamacrocyclic ligands N4TTD1–N4TTD4 have been synthesized by
the condensation of aliphatic diamines. H2N–(CH2)y–NH2 (y = 2 or 3) and dicarboxylic acids, HOOC-
(CH2)x–COOH (x = 1 or 2) in the presence of condensing reagents dicyclohexylcarbodiimide (DCHC) and 4-
dimethylaminopyridine (DMAP). On reduction these macrocyclic ligands give N4TTD5-N4TTD8, which form
complexes with manganese(II) acetate. The new products with octahedral geometry have been characterized
by elemental analyses, molecular weight determinations, magnetic moment and spectral studies viz., infrared,
electronic, mass and X-ray. On the basis of the spectral studies the binding sites are proposed as the nitrogen
atom of the macrocycles. The formulation of the complexes as [Mn(CH3COO)2(N4TTDn)] (where n = 1 - 8)
has been established on the basis of chemical composition. To assess the growth inhibiting potential of the
ligands and their manganese (II) complexes biological screening have been undertaken. The testicular
morphology, testicular sperm density, sperm motility, density of cauda epididymal spermatozoa and fertility
in mating trials and biochemical parameters of reproductive organs with ligands and their corresponding
complexes, in vivo have also been described in the this communication. |
| format | Article |
| id | doaj-art-2a2f7eff9a704c77a12ce470af7ae8f0 |
| institution | OA Journals |
| issn | 1565-3633 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-2a2f7eff9a704c77a12ce470af7ae8f02025-08-20T02:04:02ZengWileyBioinorganic Chemistry and Applications1565-36332005-01-0133-416117710.1155/BCA.2005.161Potentially Biodynamic Tetraaza Macrocycles and their Manganese Complexes: Antiandrogen, Antimicrobial and PDI StudiesAshu Chaudhary0Anita Phor1R. V. Singh2Department of Chemistry, University of Rajasthan, Jaipur 302 004, IndiaHindu College Sonipat, 131001, IndiaDepartment of Chemistry, University of Rajasthan, Jaipur 302 004, IndiaFourteen to eighteen membered tetraazamacrocyclic ligands N4TTD1–N4TTD4 have been synthesized by the condensation of aliphatic diamines. H2N–(CH2)y–NH2 (y = 2 or 3) and dicarboxylic acids, HOOC- (CH2)x–COOH (x = 1 or 2) in the presence of condensing reagents dicyclohexylcarbodiimide (DCHC) and 4- dimethylaminopyridine (DMAP). On reduction these macrocyclic ligands give N4TTD5-N4TTD8, which form complexes with manganese(II) acetate. The new products with octahedral geometry have been characterized by elemental analyses, molecular weight determinations, magnetic moment and spectral studies viz., infrared, electronic, mass and X-ray. On the basis of the spectral studies the binding sites are proposed as the nitrogen atom of the macrocycles. The formulation of the complexes as [Mn(CH3COO)2(N4TTDn)] (where n = 1 - 8) has been established on the basis of chemical composition. To assess the growth inhibiting potential of the ligands and their manganese (II) complexes biological screening have been undertaken. The testicular morphology, testicular sperm density, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs with ligands and their corresponding complexes, in vivo have also been described in the this communication.http://dx.doi.org/10.1155/BCA.2005.161 |
| spellingShingle | Ashu Chaudhary Anita Phor R. V. Singh Potentially Biodynamic Tetraaza Macrocycles and their Manganese Complexes: Antiandrogen, Antimicrobial and PDI Studies Bioinorganic Chemistry and Applications |
| title | Potentially Biodynamic Tetraaza Macrocycles and their
Manganese Complexes: Antiandrogen, Antimicrobial
and PDI Studies |
| title_full | Potentially Biodynamic Tetraaza Macrocycles and their
Manganese Complexes: Antiandrogen, Antimicrobial
and PDI Studies |
| title_fullStr | Potentially Biodynamic Tetraaza Macrocycles and their
Manganese Complexes: Antiandrogen, Antimicrobial
and PDI Studies |
| title_full_unstemmed | Potentially Biodynamic Tetraaza Macrocycles and their
Manganese Complexes: Antiandrogen, Antimicrobial
and PDI Studies |
| title_short | Potentially Biodynamic Tetraaza Macrocycles and their
Manganese Complexes: Antiandrogen, Antimicrobial
and PDI Studies |
| title_sort | potentially biodynamic tetraaza macrocycles and their manganese complexes antiandrogen antimicrobial and pdi studies |
| url | http://dx.doi.org/10.1155/BCA.2005.161 |
| work_keys_str_mv | AT ashuchaudhary potentiallybiodynamictetraazamacrocyclesandtheirmanganesecomplexesantiandrogenantimicrobialandpdistudies AT anitaphor potentiallybiodynamictetraazamacrocyclesandtheirmanganesecomplexesantiandrogenantimicrobialandpdistudies AT rvsingh potentiallybiodynamictetraazamacrocyclesandtheirmanganesecomplexesantiandrogenantimicrobialandpdistudies |