Association of cartilage T1ρ and T2 relaxation time measurement with hip osteoarthritis progression: A 5-year longitudinal study using voxel-based relaxometry and Z-score normalization
Objective: To study the longitudinal changes of cartilage T1ρ and T2 relaxation time measurements in hip-OA patients. Methods: A calibration study compared two scanner data, Scanner-1 (GE Discovery MR750 3.0T) with unilateral acquisition protocol and Scanner-2 (GE Signa Premier 3.0T) with bilateral...
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Elsevier
2024-12-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913124001055 |
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| author | Rafeek Thahakoya Koren E. Roach Misung Han Rupsa Bhattacharjee Fei Jiang Johanna Luitjens Emma Bahroos Valentina Pedoia Richard B. Souza Sharmila Majumdar |
| author_facet | Rafeek Thahakoya Koren E. Roach Misung Han Rupsa Bhattacharjee Fei Jiang Johanna Luitjens Emma Bahroos Valentina Pedoia Richard B. Souza Sharmila Majumdar |
| author_sort | Rafeek Thahakoya |
| collection | DOAJ |
| description | Objective: To study the longitudinal changes of cartilage T1ρ and T2 relaxation time measurements in hip-OA patients. Methods: A calibration study compared two scanner data, Scanner-1 (GE Discovery MR750 3.0T) with unilateral acquisition protocol and Scanner-2 (GE Signa Premier 3.0T) with bilateral acquisition protocol, using nine subjects(average age = 40.33 ± 13.53 years, 5 females), including one hip-OA subject. Quantified parameters from the Scanner-2 were adjusted using voxel-based relaxometry(VBR) and Z-score normalization to reduce the inter-scanner variability. Eighteen hip-OA Subjects (age = 53.11 ± 14.96 years, 12 females) were recruited to the longitudinal variability study from 2016, comprising five assessments at 1-year intervals. Baseline to 3rd-year data used unilateral acquisition with Scanner-1, while 4th-year data used bilateral acquisition with Scanner-2. A linear mixed-effects model(LME) assessed trajectory analyses, with acquisition year, age, sex, body mass index(BMI), and Kellgren-Lawrence(KL) score as predictor variables and cartilage mean T1ρ and T2 values as outcomes. Results: VBR analysis after Z-score normalization showed that only a few of the whole cartilage voxels had significant differences in T1ρ(femur-2.36 % and acetabular-3.23 %) and T2 (femur-2.30 % and acetabular-2.94 %) values between the scanners. The LME analysis showed that the BMI predictor variable was significantly correlated with the femur T1ρ (p < 0.0001) and T2 (p < 0.0001) and acetabular T1ρ (p < 0.0001) and T2 (p < 0.0001) cartilage region. Conclusion: The calibration study demonstrated the effectiveness of VBR and Z-score normalization in reducing inter-scanner variability. The longitudinal study revealed a significant correlation between T1ρ and T2 values of the cartilage and BMI; also the T1ρ and T2 values increased over time in some of the cartilage subregions. |
| format | Article |
| id | doaj-art-2a28c04fd2c04366a0abbfbb1ee8f21d |
| institution | OA Journals |
| issn | 2665-9131 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-2a28c04fd2c04366a0abbfbb1ee8f21d2025-08-20T01:52:45ZengElsevierOsteoarthritis and Cartilage Open2665-91312024-12-016410053810.1016/j.ocarto.2024.100538Association of cartilage T1ρ and T2 relaxation time measurement with hip osteoarthritis progression: A 5-year longitudinal study using voxel-based relaxometry and Z-score normalizationRafeek Thahakoya0Koren E. Roach1Misung Han2Rupsa Bhattacharjee3Fei Jiang4Johanna Luitjens5Emma Bahroos6Valentina Pedoia7Richard B. Souza8Sharmila Majumdar9Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA; Corresponding author. 1700 4th Street, #201, San Francisco, CA 94158, USA.Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA; Department of Biomedical Engineering, Schulich School of Engineering, University of Calgary, Calgary, Alberta, Canada; Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, Calgary, Alberta, CanadaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USADepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USADepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USADepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USADepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USADepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USADepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA; Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, USADepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USAObjective: To study the longitudinal changes of cartilage T1ρ and T2 relaxation time measurements in hip-OA patients. Methods: A calibration study compared two scanner data, Scanner-1 (GE Discovery MR750 3.0T) with unilateral acquisition protocol and Scanner-2 (GE Signa Premier 3.0T) with bilateral acquisition protocol, using nine subjects(average age = 40.33 ± 13.53 years, 5 females), including one hip-OA subject. Quantified parameters from the Scanner-2 were adjusted using voxel-based relaxometry(VBR) and Z-score normalization to reduce the inter-scanner variability. Eighteen hip-OA Subjects (age = 53.11 ± 14.96 years, 12 females) were recruited to the longitudinal variability study from 2016, comprising five assessments at 1-year intervals. Baseline to 3rd-year data used unilateral acquisition with Scanner-1, while 4th-year data used bilateral acquisition with Scanner-2. A linear mixed-effects model(LME) assessed trajectory analyses, with acquisition year, age, sex, body mass index(BMI), and Kellgren-Lawrence(KL) score as predictor variables and cartilage mean T1ρ and T2 values as outcomes. Results: VBR analysis after Z-score normalization showed that only a few of the whole cartilage voxels had significant differences in T1ρ(femur-2.36 % and acetabular-3.23 %) and T2 (femur-2.30 % and acetabular-2.94 %) values between the scanners. The LME analysis showed that the BMI predictor variable was significantly correlated with the femur T1ρ (p < 0.0001) and T2 (p < 0.0001) and acetabular T1ρ (p < 0.0001) and T2 (p < 0.0001) cartilage region. Conclusion: The calibration study demonstrated the effectiveness of VBR and Z-score normalization in reducing inter-scanner variability. The longitudinal study revealed a significant correlation between T1ρ and T2 values of the cartilage and BMI; also the T1ρ and T2 values increased over time in some of the cartilage subregions.http://www.sciencedirect.com/science/article/pii/S2665913124001055Articular cartilageHip osteoarthritisVBR analysisLongitudinal study |
| spellingShingle | Rafeek Thahakoya Koren E. Roach Misung Han Rupsa Bhattacharjee Fei Jiang Johanna Luitjens Emma Bahroos Valentina Pedoia Richard B. Souza Sharmila Majumdar Association of cartilage T1ρ and T2 relaxation time measurement with hip osteoarthritis progression: A 5-year longitudinal study using voxel-based relaxometry and Z-score normalization Osteoarthritis and Cartilage Open Articular cartilage Hip osteoarthritis VBR analysis Longitudinal study |
| title | Association of cartilage T1ρ and T2 relaxation time measurement with hip osteoarthritis progression: A 5-year longitudinal study using voxel-based relaxometry and Z-score normalization |
| title_full | Association of cartilage T1ρ and T2 relaxation time measurement with hip osteoarthritis progression: A 5-year longitudinal study using voxel-based relaxometry and Z-score normalization |
| title_fullStr | Association of cartilage T1ρ and T2 relaxation time measurement with hip osteoarthritis progression: A 5-year longitudinal study using voxel-based relaxometry and Z-score normalization |
| title_full_unstemmed | Association of cartilage T1ρ and T2 relaxation time measurement with hip osteoarthritis progression: A 5-year longitudinal study using voxel-based relaxometry and Z-score normalization |
| title_short | Association of cartilage T1ρ and T2 relaxation time measurement with hip osteoarthritis progression: A 5-year longitudinal study using voxel-based relaxometry and Z-score normalization |
| title_sort | association of cartilage t1ρ and t2 relaxation time measurement with hip osteoarthritis progression a 5 year longitudinal study using voxel based relaxometry and z score normalization |
| topic | Articular cartilage Hip osteoarthritis VBR analysis Longitudinal study |
| url | http://www.sciencedirect.com/science/article/pii/S2665913124001055 |
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