Age outweighs race in survival of sebaceous gland carcinoma of the eyelid: A 21-year SEER database analysis
Purpose: Sebaceous gland carcinomas (SC) are rare neoplasms arising from the eyelids’ sebaceous glands. Investigating racial disparities in their occurrence, management, and outcomes is crucial for enhancing patient care. Design: Retrospective database analysis. Methods: Data were extracted from the...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
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| Series: | AJO International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950253525000322 |
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| Summary: | Purpose: Sebaceous gland carcinomas (SC) are rare neoplasms arising from the eyelids’ sebaceous glands. Investigating racial disparities in their occurrence, management, and outcomes is crucial for enhancing patient care. Design: Retrospective database analysis. Methods: Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database, which collects cancer incidence and survival data from diverse geographic regions in the United States, representing approximately 48 % of the U.S. population, for patients diagnosed with SC between 2000 and 2021. Patients were stratified into four racial groups: White, Black, Asian/Pacific Islander, and American Indian/Alaska Native. Incidence rates, stage at diagnosis, treatment modalities, and survival outcomes were analyzed. A multivariate Cox regression model assessed the prognostic impact of age and radiation therapy on survival, adjusting for relevant confounders. Results: Among 969 patients diagnosed with eyelid SC, 615 were aged 70 years or older, accounting for approximately 63 percent, with a slight female predominance of 55.5 percent. White patients had survival rates of 49.5 % while patients from other racial groups had survival rates of 59.3 %. The Log-Rank test found no statistically significant survival differences by race (P = 0.075). Multivariate analysis identified advanced age (≥70 years) as a strong independent prognostic factor for decreased survival (hazard ratio = 4.50, CI: 2.67–7.59: p < 0.001). Additionally, radiation therapy was significantly associated with an increased risk of mortality (hazard ratio = 1.59, 95 % CI: 1.10–2.29; p = 0.01), highlighting its prognostic significance in the management of SC. While race was not statistically significant, white race exhibited a higher risk (hazard ratio = 1.16, CI: 0.88–1.53; p = 0.28). Conclusion: Survival outcomes did not significantly differ by race; however, age was identified as a critical prognostic factor. Larger sample sizes are needed to establish additional risk factors and assess potential disparities among underrepresented populations. |
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| ISSN: | 2950-2535 |