Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic Studies
An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta with a diameter of at least 3.0 cm. AAAs are often asymptomatic and are discovered as incidental findings in imaging studies or when the AAA ruptures leading to a medical emergency. AAAs are more common in males than females,...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2014/564734 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849307837089447936 |
|---|---|
| author | Helena Kuivaniemi Evan J. Ryer James R. Elmore Irene Hinterseher Diane T. Smelser Gerard Tromp |
| author_facet | Helena Kuivaniemi Evan J. Ryer James R. Elmore Irene Hinterseher Diane T. Smelser Gerard Tromp |
| author_sort | Helena Kuivaniemi |
| collection | DOAJ |
| description | An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta with a diameter of at least 3.0 cm. AAAs are often asymptomatic and are discovered as incidental findings in imaging studies or when the AAA ruptures leading to a medical emergency. AAAs are more common in males than females, in individuals of European ancestry, and in those over 65 years of age. Smoking is the most important environmental risk factor. In addition, a positive family history of AAA increases the person’s risk for AAA. Interestingly, diabetes has been shown to be a protective factor for AAA in many large studies. Hallmarks of AAA pathogenesis include inflammation, vascular smooth muscle cell apoptosis, extracellular matrix degradation, and oxidative stress. Autoimmunity may also play a role in AAA development and progression. In this Outlook paper, we summarize our recent studies on AAA including clinical studies related to surgical repair of AAA and genetic risk factor and large-scale gene expression studies. We conclude with a discussion on our research projects using large data sets available through electronic medical records and biobanks. |
| format | Article |
| id | doaj-art-2a1f10fa1eb347ad853f4315c356a2d5 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-2a1f10fa1eb347ad853f4315c356a2d52025-08-20T03:54:37ZengWileyScientifica2090-908X2014-01-01201410.1155/2014/564734564734Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic StudiesHelena Kuivaniemi0Evan J. Ryer1James R. Elmore2Irene Hinterseher3Diane T. Smelser4Gerard Tromp5The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, PA, USADepartment of Surgery, Temple University School of Medicine, Philadelphia, PA, USADepartment of Surgery, Temple University School of Medicine, Philadelphia, PA, USADepartment of General, Visceral, Vascular and Thoracic Surgery, Charité Universitätsmedizin Berlin, Charité Campus Mitte, Berlin, GermanyThe Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, PA, USAThe Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, PA, USAAn abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta with a diameter of at least 3.0 cm. AAAs are often asymptomatic and are discovered as incidental findings in imaging studies or when the AAA ruptures leading to a medical emergency. AAAs are more common in males than females, in individuals of European ancestry, and in those over 65 years of age. Smoking is the most important environmental risk factor. In addition, a positive family history of AAA increases the person’s risk for AAA. Interestingly, diabetes has been shown to be a protective factor for AAA in many large studies. Hallmarks of AAA pathogenesis include inflammation, vascular smooth muscle cell apoptosis, extracellular matrix degradation, and oxidative stress. Autoimmunity may also play a role in AAA development and progression. In this Outlook paper, we summarize our recent studies on AAA including clinical studies related to surgical repair of AAA and genetic risk factor and large-scale gene expression studies. We conclude with a discussion on our research projects using large data sets available through electronic medical records and biobanks.http://dx.doi.org/10.1155/2014/564734 |
| spellingShingle | Helena Kuivaniemi Evan J. Ryer James R. Elmore Irene Hinterseher Diane T. Smelser Gerard Tromp Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic Studies Scientifica |
| title | Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic Studies |
| title_full | Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic Studies |
| title_fullStr | Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic Studies |
| title_full_unstemmed | Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic Studies |
| title_short | Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic Studies |
| title_sort | update on abdominal aortic aneurysm research from clinical to genetic studies |
| url | http://dx.doi.org/10.1155/2014/564734 |
| work_keys_str_mv | AT helenakuivaniemi updateonabdominalaorticaneurysmresearchfromclinicaltogeneticstudies AT evanjryer updateonabdominalaorticaneurysmresearchfromclinicaltogeneticstudies AT jamesrelmore updateonabdominalaorticaneurysmresearchfromclinicaltogeneticstudies AT irenehinterseher updateonabdominalaorticaneurysmresearchfromclinicaltogeneticstudies AT dianetsmelser updateonabdominalaorticaneurysmresearchfromclinicaltogeneticstudies AT gerardtromp updateonabdominalaorticaneurysmresearchfromclinicaltogeneticstudies |