Clinical Clues and Diagnostic Workup of Cardiac Amyloidosis
Cardiac amyloidosis is increasingly recognized as an underlying cause of left ventricular wall thickening, heart failure, and arrhythmia with variable clinical presentation. Due to the subtle cardiac findings in early transthyretin cardiac amyloidosis and the availability of therapies that can modif...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Houston Methodist DeBakey Heart & Vascular Center
2022-03-01
|
| Series: | Methodist DeBakey Cardiovascular Journal |
| Subjects: | |
| Online Access: | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1061 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850128275988283392 |
|---|---|
| author | Sajan S. Gill Eric Fellin Lisa Stampke Yuanzi Zhao Ahmad Masri |
| author_facet | Sajan S. Gill Eric Fellin Lisa Stampke Yuanzi Zhao Ahmad Masri |
| author_sort | Sajan S. Gill |
| collection | DOAJ |
| description | Cardiac amyloidosis is increasingly recognized as an underlying cause of left ventricular wall thickening, heart failure, and arrhythmia with variable clinical presentation. Due to the subtle cardiac findings in early transthyretin cardiac amyloidosis and the availability of therapies that can modify but not reverse the disease progression, early recognition is vital. In light chain amyloidosis, timely diagnosis and treatment can significantly improve survival. In this manuscript, we review the clinical, imaging, and electrocardiographic clues that should raise suspicion for cardiac amyloidosis and provide a simplified diagnostic workup algorithm that ensures an accurate diagnosis. The evolution of the noninvasive diagnosis of cardiac amyloidosis has significantly influenced our understanding of disease prevalence, presentations, and outcomes. However, clinical recognition of clues and red flags remains the most important factor in advancing the care of patients with cardiac amyloidosis. |
| format | Article |
| id | doaj-art-2a1e0874492948a4b5647705d7d08c7a |
| institution | OA Journals |
| issn | 1947-6108 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Houston Methodist DeBakey Heart & Vascular Center |
| record_format | Article |
| series | Methodist DeBakey Cardiovascular Journal |
| spelling | doaj-art-2a1e0874492948a4b5647705d7d08c7a2025-08-20T02:33:23ZengHouston Methodist DeBakey Heart & Vascular CenterMethodist DeBakey Cardiovascular Journal1947-61082022-03-01182364610.14797/mdcvj.1061398Clinical Clues and Diagnostic Workup of Cardiac AmyloidosisSajan S. Gill0https://orcid.org/0000-0002-9156-7103Eric Fellin1Lisa Stampke2Yuanzi Zhao3Ahmad Masri4https://orcid.org/0000-0002-6390-6526Knight Cardiovascular Institute, Oregon Health & Science University School of Medicine, Portland, OregonOregon Health & Science University School of Medicine, Portland, OregonOregon Health & Science University School of Medicine, Portland, OregonKnight Cardiovascular Institute, Oregon Health & Science University School of Medicine, Portland, OregonKnight Cardiovascular Institute, Oregon Health & Science University School of Medicine, Portland, OregonCardiac amyloidosis is increasingly recognized as an underlying cause of left ventricular wall thickening, heart failure, and arrhythmia with variable clinical presentation. Due to the subtle cardiac findings in early transthyretin cardiac amyloidosis and the availability of therapies that can modify but not reverse the disease progression, early recognition is vital. In light chain amyloidosis, timely diagnosis and treatment can significantly improve survival. In this manuscript, we review the clinical, imaging, and electrocardiographic clues that should raise suspicion for cardiac amyloidosis and provide a simplified diagnostic workup algorithm that ensures an accurate diagnosis. The evolution of the noninvasive diagnosis of cardiac amyloidosis has significantly influenced our understanding of disease prevalence, presentations, and outcomes. However, clinical recognition of clues and red flags remains the most important factor in advancing the care of patients with cardiac amyloidosis.https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1061cardiac amyloidosissystemic amyloidosisimmunoglobulin light chaintransthyretinleft ventricular hypertrophyheart failureaortic stenosisbone scintigraphycardiac magnetic resonance imagingendomyocardial biopsy |
| spellingShingle | Sajan S. Gill Eric Fellin Lisa Stampke Yuanzi Zhao Ahmad Masri Clinical Clues and Diagnostic Workup of Cardiac Amyloidosis Methodist DeBakey Cardiovascular Journal cardiac amyloidosis systemic amyloidosis immunoglobulin light chain transthyretin left ventricular hypertrophy heart failure aortic stenosis bone scintigraphy cardiac magnetic resonance imaging endomyocardial biopsy |
| title | Clinical Clues and Diagnostic Workup of Cardiac Amyloidosis |
| title_full | Clinical Clues and Diagnostic Workup of Cardiac Amyloidosis |
| title_fullStr | Clinical Clues and Diagnostic Workup of Cardiac Amyloidosis |
| title_full_unstemmed | Clinical Clues and Diagnostic Workup of Cardiac Amyloidosis |
| title_short | Clinical Clues and Diagnostic Workup of Cardiac Amyloidosis |
| title_sort | clinical clues and diagnostic workup of cardiac amyloidosis |
| topic | cardiac amyloidosis systemic amyloidosis immunoglobulin light chain transthyretin left ventricular hypertrophy heart failure aortic stenosis bone scintigraphy cardiac magnetic resonance imaging endomyocardial biopsy |
| url | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1061 |
| work_keys_str_mv | AT sajansgill clinicalcluesanddiagnosticworkupofcardiacamyloidosis AT ericfellin clinicalcluesanddiagnosticworkupofcardiacamyloidosis AT lisastampke clinicalcluesanddiagnosticworkupofcardiacamyloidosis AT yuanzizhao clinicalcluesanddiagnosticworkupofcardiacamyloidosis AT ahmadmasri clinicalcluesanddiagnosticworkupofcardiacamyloidosis |