NITROIMIDAZOLES VIII [I]. SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-PYRIDYL-NITROIMIDAZOLES
Starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles (2-5) were prepared. From the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole (15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3- pyridy1)-4-nitroimidazole (6,)w as prepared. Reaction of compound 15 with diazomethan...
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| Format: | Article |
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| Language: | English |
| Published: |
University of Tehran
1990-06-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Online Access: | https://jsciences.ut.ac.ir/article_31325_61cf2735d9cfb28c7d99ac4350f15b56.pdf |
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| Summary: | Starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles
(2-5) were prepared. From the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole
(15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3-
pyridy1)-4-nitroimidazole (6,)w as prepared. Reaction of compound 15 with diazomethane gave I-methyl-2-(3-pyridy1)-5- nitroimidazol(e7 ) in addition to 6. The antibacterial and antifungal activities of compounds 5, 6, and 7 against a number of microorganisms were determined |
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| ISSN: | 1016-1104 2345-6914 |