Analysis of histone modifications in key cellular subpopulations in the context of azoospermia using spermatogenic single-cell RNA-seq data

Analysis of histone modifications in key cellular subpopulations in the context of azoospermia using spermatogenic single-cell RNA-seq data

IntroductionThe molecular underpinnings of non-obstructive azoospermia (NOA), a severe form of male infertility characterized by the absence of sperm in the ejaculate, remain unclear.MethodsIn this study, we demonstrate the role of histone modifications within specific testicular cell subpopulations...

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Bibliographic Details
Main Authors: Qiu Wang, Hong Yang, Fang Li, Song Ge, Ling Ji, Xiaofeng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bioinformatics
Subjects:
male infertility
histone modification gene
non-obstructive azoospermia
single-cell RNA sequencing
Leydig cells
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1626153/full
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