Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders
Overweight and obesity lead to an increased risk for metabolic disorders such as impaired glucose regulation/insulin resistance, dyslipidemia, and hypertension. Several molecular drug targets with potential to prevent or treat metabolic disorders have been revealed. Interestingly, the activation of...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/679137 |
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| _version_ | 1849307835356151808 |
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| author | Min-Chul Cho Kyoung Lee Sang-Gi Paik Do-Young Yoon |
| author_facet | Min-Chul Cho Kyoung Lee Sang-Gi Paik Do-Young Yoon |
| author_sort | Min-Chul Cho |
| collection | DOAJ |
| description | Overweight and obesity lead to an increased risk for metabolic disorders such as impaired glucose regulation/insulin resistance, dyslipidemia, and hypertension. Several molecular drug targets with potential to prevent or treat metabolic disorders have been revealed. Interestingly, the activation of peroxisome proliferator-activated receptor (PPAR), which belongs to the nuclear receptor superfamily, has many beneficial clinical effects. PPAR directly modulates gene expression by binding to a specific ligand. All PPAR subtypes (α,γ, and σ) are involved in glucose metabolism, lipid metabolism, and energy balance. PPAR agonists play an important role in therapeutic aspects of metabolic disorders. However, undesired effects of the existing PPAR agonists have been reported. A great deal of recent research has focused on the discovery of new PPAR modulators with more beneficial effects and more safety without producing undesired side effects. Herein, we briefly review the roles of PPAR in metabolic disorders, the effects of PPAR modulators in metabolic disorders, and the technologies with which to discover new PPAR modulators. |
| format | Article |
| id | doaj-art-2a1d1cd2494d429eb3f01eac42089dd5 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-2a1d1cd2494d429eb3f01eac42089dd52025-08-20T03:54:37ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/679137679137Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic DisordersMin-Chul Cho0Kyoung Lee1Sang-Gi Paik2Do-Young Yoon3Department of Bioscience & Biotechnology, Konkuk University, Seoul 143-701, South KoreaDepartment of Microbiology, Changwon National University, Changwon 641-773, South KoreaDepartment of Biology, Chungnam National University, Daejeon 305-764, South KoreaDepartment of Bioscience & Biotechnology, Konkuk University, Seoul 143-701, South KoreaOverweight and obesity lead to an increased risk for metabolic disorders such as impaired glucose regulation/insulin resistance, dyslipidemia, and hypertension. Several molecular drug targets with potential to prevent or treat metabolic disorders have been revealed. Interestingly, the activation of peroxisome proliferator-activated receptor (PPAR), which belongs to the nuclear receptor superfamily, has many beneficial clinical effects. PPAR directly modulates gene expression by binding to a specific ligand. All PPAR subtypes (α,γ, and σ) are involved in glucose metabolism, lipid metabolism, and energy balance. PPAR agonists play an important role in therapeutic aspects of metabolic disorders. However, undesired effects of the existing PPAR agonists have been reported. A great deal of recent research has focused on the discovery of new PPAR modulators with more beneficial effects and more safety without producing undesired side effects. Herein, we briefly review the roles of PPAR in metabolic disorders, the effects of PPAR modulators in metabolic disorders, and the technologies with which to discover new PPAR modulators.http://dx.doi.org/10.1155/2008/679137 |
| spellingShingle | Min-Chul Cho Kyoung Lee Sang-Gi Paik Do-Young Yoon Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders PPAR Research |
| title | Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders |
| title_full | Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders |
| title_fullStr | Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders |
| title_full_unstemmed | Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders |
| title_short | Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders |
| title_sort | peroxisome proliferators activated receptor ppar modulators and metabolic disorders |
| url | http://dx.doi.org/10.1155/2008/679137 |
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