A Rare Q-Fever Infection Diagnosed Using Metagenomic Next-Generation Sequencing in Liver Transplantation Patient: A Case Report and Literature Review
Xinxin Niu,1,* Shuang Qiu,1,* Yafeng Zheng,2,* Li Li,1 Eryun Tian,1 Jie Liu,1 Wei Gai,2 Qing Zhang,1 Hailong Jin1 1Department of Organ Transplantation, The Third Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 2WillingMed Technology (Beiji...
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Dove Medical Press
2025-01-01
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| Series: | Infection and Drug Resistance |
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| author | Niu X Qiu S Zheng Y Li L Tian E Liu J Gai W Zhang Q Jin H |
| author_facet | Niu X Qiu S Zheng Y Li L Tian E Liu J Gai W Zhang Q Jin H |
| author_sort | Niu X |
| collection | DOAJ |
| description | Xinxin Niu,1,* Shuang Qiu,1,* Yafeng Zheng,2,* Li Li,1 Eryun Tian,1 Jie Liu,1 Wei Gai,2 Qing Zhang,1 Hailong Jin1 1Department of Organ Transplantation, The Third Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 2WillingMed Technology (Beijing) Co., Ltd, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qing Zhang; Hailong Jin, Department of Organ Transplantation, The Third Medical Center of Chinese PLA General Hospital, Beijing, 100039, People’s Republic of China, Email zqy6920@sina.com; jhl309@sina.comAbstract: Q fever is a zoonotic disease caused by the Gram-negative bacterium Coxiella burnetii, typically transmitted through exposure to infected animal secretions. As the clinical signs of Q-fever are largely non-specific in humans, a definitive diagnosis can often be overlooked, particularly when physicians fail to consider C. burnetii on the list of differentials. This case report describes Q-fever in a male patient who had previously undergone orthotopic liver transplantation. The patient had a sudden onset of fever and received the anti-infective moxifloxacin which proved ineffective. Despite the comprehensive laboratory tests and CT imaging that were performed, the etiology remained undetermined. The patient’s blood was subjected to metagenomic next-generation sequencing (mNGS), which identified C. burnetii, after which the patient was treated with doxycycline and recovered well. Eight literature articles on Q fever infection in solid organ transplant recipients were reviewed. To our knowledge, this is the first case of Q fever identified by mNGS in an organ transplantation patient. The case underscores the potential of mNGS has in aiding the rapid detection of rare pathogens in immunocompromised patients.Keywords: Q-fever, metagenomic next-generation sequencing, case report, liver transplant, Coxiella burnetii |
| format | Article |
| id | doaj-art-2a1a4f51db9345a78f26242c93c04bd7 |
| institution | Kabale University |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj-art-2a1a4f51db9345a78f26242c93c04bd72025-01-05T16:36:04ZengDove Medical PressInfection and Drug Resistance1178-69732025-01-01Volume 18253098924A Rare Q-Fever Infection Diagnosed Using Metagenomic Next-Generation Sequencing in Liver Transplantation Patient: A Case Report and Literature ReviewNiu XQiu SZheng YLi LTian ELiu JGai WZhang QJin HXinxin Niu,1,* Shuang Qiu,1,* Yafeng Zheng,2,* Li Li,1 Eryun Tian,1 Jie Liu,1 Wei Gai,2 Qing Zhang,1 Hailong Jin1 1Department of Organ Transplantation, The Third Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 2WillingMed Technology (Beijing) Co., Ltd, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qing Zhang; Hailong Jin, Department of Organ Transplantation, The Third Medical Center of Chinese PLA General Hospital, Beijing, 100039, People’s Republic of China, Email zqy6920@sina.com; jhl309@sina.comAbstract: Q fever is a zoonotic disease caused by the Gram-negative bacterium Coxiella burnetii, typically transmitted through exposure to infected animal secretions. As the clinical signs of Q-fever are largely non-specific in humans, a definitive diagnosis can often be overlooked, particularly when physicians fail to consider C. burnetii on the list of differentials. This case report describes Q-fever in a male patient who had previously undergone orthotopic liver transplantation. The patient had a sudden onset of fever and received the anti-infective moxifloxacin which proved ineffective. Despite the comprehensive laboratory tests and CT imaging that were performed, the etiology remained undetermined. The patient’s blood was subjected to metagenomic next-generation sequencing (mNGS), which identified C. burnetii, after which the patient was treated with doxycycline and recovered well. Eight literature articles on Q fever infection in solid organ transplant recipients were reviewed. To our knowledge, this is the first case of Q fever identified by mNGS in an organ transplantation patient. The case underscores the potential of mNGS has in aiding the rapid detection of rare pathogens in immunocompromised patients.Keywords: Q-fever, metagenomic next-generation sequencing, case report, liver transplant, Coxiella burnetiihttps://www.dovepress.com/a-rare-q-fever-infection-diagnosed-using-metagenomic-next-generation-s-peer-reviewed-fulltext-article-IDRq-fevermetagenomic next-generation sequencingcase reportliver transplantcoxiella burnetiid |
| spellingShingle | Niu X Qiu S Zheng Y Li L Tian E Liu J Gai W Zhang Q Jin H A Rare Q-Fever Infection Diagnosed Using Metagenomic Next-Generation Sequencing in Liver Transplantation Patient: A Case Report and Literature Review Infection and Drug Resistance q-fever metagenomic next-generation sequencing case report liver transplant coxiella burnetiid |
| title | A Rare Q-Fever Infection Diagnosed Using Metagenomic Next-Generation Sequencing in Liver Transplantation Patient: A Case Report and Literature Review |
| title_full | A Rare Q-Fever Infection Diagnosed Using Metagenomic Next-Generation Sequencing in Liver Transplantation Patient: A Case Report and Literature Review |
| title_fullStr | A Rare Q-Fever Infection Diagnosed Using Metagenomic Next-Generation Sequencing in Liver Transplantation Patient: A Case Report and Literature Review |
| title_full_unstemmed | A Rare Q-Fever Infection Diagnosed Using Metagenomic Next-Generation Sequencing in Liver Transplantation Patient: A Case Report and Literature Review |
| title_short | A Rare Q-Fever Infection Diagnosed Using Metagenomic Next-Generation Sequencing in Liver Transplantation Patient: A Case Report and Literature Review |
| title_sort | rare q fever infection diagnosed using metagenomic next generation sequencing in liver transplantation patient a case report and literature review |
| topic | q-fever metagenomic next-generation sequencing case report liver transplant coxiella burnetiid |
| url | https://www.dovepress.com/a-rare-q-fever-infection-diagnosed-using-metagenomic-next-generation-s-peer-reviewed-fulltext-article-IDR |
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