Nutritional assessment using subjective global assessment identifies energy malnutrition and predicts mortality in patients with liver cirrhosis
Abstract This study aimed to evaluate whether the subjective global assessment (SGA) could effectively predict energy malnutrition, as assessed by indirect calorimetry, and mortality in hospitalized patients with cirrhosis. Energy malnutrition was defined by a nonprotein respiratory quotient (npRQ) ...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-89803-6 |
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| author | Takao Miwa Tatsunori Hanai Kayoko Nishimura Sachiyo Hirata Shinji Unome Yuki Nakahata Kenji Imai Atsushi Suetsugu Koji Takai Masahito Shimizu |
| author_facet | Takao Miwa Tatsunori Hanai Kayoko Nishimura Sachiyo Hirata Shinji Unome Yuki Nakahata Kenji Imai Atsushi Suetsugu Koji Takai Masahito Shimizu |
| author_sort | Takao Miwa |
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| description | Abstract This study aimed to evaluate whether the subjective global assessment (SGA) could effectively predict energy malnutrition, as assessed by indirect calorimetry, and mortality in hospitalized patients with cirrhosis. Energy malnutrition was defined by a nonprotein respiratory quotient (npRQ) < 0.85 using an indirect calorimetry. The usefulness of the SGA in identifying energy malnutrition and predicting mortality was assessed by the logistic regression and Cox proportional hazards models, respectively. Out of the 230 patients analyzed, 43% were found to have energy malnutrition. The distribution of SGA classifications was 54% for SGA-A, 32% for SGA-B, and 14% for SGA-C. Multivariable analysis indicated that both SGA-B (odds ratio, 3.59; 95% confidence interval [CI], 1.59–8.10) and SGA-C (odds ratio, 19.70; 95% CI, 3.46–112.00), along with free fatty acids (FFA), were independently linked to energy malnutrition. Regarding mortality, 125 patients (54%) died over a median follow-up period of 2.8 years. After adjustment, SGA-B (hazard ratio, 1.81; 95% CI, 1.08–3.03) and SGA-C (hazard ratio, 3.35; 95% CI, 1.28–8.76) were predictors of mortality in cirrhosis patients, while energy malnutrition and FFA were not. The SGA is a valuable tool for identifying energy malnutrition and predicting mortality in patients with cirrhosis. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-2a1a2125d4be454fb16e3d104e49322e2025-02-09T12:36:27ZengNature PortfolioScientific Reports2045-23222025-02-011511810.1038/s41598-025-89803-6Nutritional assessment using subjective global assessment identifies energy malnutrition and predicts mortality in patients with liver cirrhosisTakao Miwa0Tatsunori Hanai1Kayoko Nishimura2Sachiyo Hirata3Shinji Unome4Yuki Nakahata5Kenji Imai6Atsushi Suetsugu7Koji Takai8Masahito Shimizu9Department of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu UniversityDepartment of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu UniversityCenter for Nutrition Support & Infection Control, Gifu University HospitalCenter for Nutrition Support & Infection Control, Gifu University HospitalDepartment of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu UniversityDepartment of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu UniversityDepartment of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu UniversityDepartment of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu UniversityDepartment of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu UniversityDepartment of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu UniversityAbstract This study aimed to evaluate whether the subjective global assessment (SGA) could effectively predict energy malnutrition, as assessed by indirect calorimetry, and mortality in hospitalized patients with cirrhosis. Energy malnutrition was defined by a nonprotein respiratory quotient (npRQ) < 0.85 using an indirect calorimetry. The usefulness of the SGA in identifying energy malnutrition and predicting mortality was assessed by the logistic regression and Cox proportional hazards models, respectively. Out of the 230 patients analyzed, 43% were found to have energy malnutrition. The distribution of SGA classifications was 54% for SGA-A, 32% for SGA-B, and 14% for SGA-C. Multivariable analysis indicated that both SGA-B (odds ratio, 3.59; 95% confidence interval [CI], 1.59–8.10) and SGA-C (odds ratio, 19.70; 95% CI, 3.46–112.00), along with free fatty acids (FFA), were independently linked to energy malnutrition. Regarding mortality, 125 patients (54%) died over a median follow-up period of 2.8 years. After adjustment, SGA-B (hazard ratio, 1.81; 95% CI, 1.08–3.03) and SGA-C (hazard ratio, 3.35; 95% CI, 1.28–8.76) were predictors of mortality in cirrhosis patients, while energy malnutrition and FFA were not. The SGA is a valuable tool for identifying energy malnutrition and predicting mortality in patients with cirrhosis.https://doi.org/10.1038/s41598-025-89803-6Chronic liver diseaseLiver cirrhosisNutritionSarcopeniaSurvivalMalnutrition |
| spellingShingle | Takao Miwa Tatsunori Hanai Kayoko Nishimura Sachiyo Hirata Shinji Unome Yuki Nakahata Kenji Imai Atsushi Suetsugu Koji Takai Masahito Shimizu Nutritional assessment using subjective global assessment identifies energy malnutrition and predicts mortality in patients with liver cirrhosis Scientific Reports Chronic liver disease Liver cirrhosis Nutrition Sarcopenia Survival Malnutrition |
| title | Nutritional assessment using subjective global assessment identifies energy malnutrition and predicts mortality in patients with liver cirrhosis |
| title_full | Nutritional assessment using subjective global assessment identifies energy malnutrition and predicts mortality in patients with liver cirrhosis |
| title_fullStr | Nutritional assessment using subjective global assessment identifies energy malnutrition and predicts mortality in patients with liver cirrhosis |
| title_full_unstemmed | Nutritional assessment using subjective global assessment identifies energy malnutrition and predicts mortality in patients with liver cirrhosis |
| title_short | Nutritional assessment using subjective global assessment identifies energy malnutrition and predicts mortality in patients with liver cirrhosis |
| title_sort | nutritional assessment using subjective global assessment identifies energy malnutrition and predicts mortality in patients with liver cirrhosis |
| topic | Chronic liver disease Liver cirrhosis Nutrition Sarcopenia Survival Malnutrition |
| url | https://doi.org/10.1038/s41598-025-89803-6 |
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