Structural Insights into Salinosporamide a Mediated Inhibition of the Human 20S Proteasome

Structural Insights into Salinosporamide a Mediated Inhibition of the Human 20S Proteasome

The 20S proteasome, a critical component of the ubiquitin–proteasome system, plays a central role in regulating protein degradation in eukaryotic cells. Marizomib (MZB), also known as salinosporamide A, is a natural γ-lactam-β-lactone compound derived from <i>Salinispora tropica</i> and...

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Bibliographic Details
Main Authors: Hagen Sülzen, Pavla Fajtova, Anthony J. O’Donoghue, Jan Silhan, Evzen Boura
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Molecules
Subjects:
20S
proteasome
marizomib
MZB
cryo-EM
Online Access:https://www.mdpi.com/1420-3049/30/6/1386
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