Lack of canonical activities of connexins in highly aggressive human prostate cancer cells

Lack of canonical activities of connexins in highly aggressive human prostate cancer cells

Abstract Connexins (Cxs) have the ability to form channels that allow the exchange of ions/metabolites between adjacent cells (gap junction channels, GJC) or between the intra- and extra-cellular compartments (hemichannels, HC). Cxs were initially classified as tumor suppressors. However, more recen...

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Main Authors: Catalina Asencio, Loreto Véliz, Emilia Flores-Faúndez, Lorena Azócar, Carolina E. Echeverría, Verónica Torres-Estay, Viviana Orellana, Catalina Ramírez-Santelices, Paula Sotomayor, Jorge Cancino, Bredford Kerr, Ainoa Fernandez-Olivares, Mauricio A. Retamal, Juan C. Sáez, Alejandro S. Godoy
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Biological Research
Subjects:
Prostate cancer
Connexins
Gap junctions
Hemichannels
Online Access:https://doi.org/10.1186/s40659-024-00565-3
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