Reassessing lidocaine as an electroporation sensitizer in vitro

Reassessing lidocaine as an electroporation sensitizer in vitro

Abstract High-intensity pulsed electric fields induce transient increase in membrane permeability, a phenomenon known as electroporation, with broad applications in medicine, including electrochemotherapy (ECT), gene electrotransfer and tissue ablation. As electroporation technologies become increas...

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Bibliographic Details
Main Authors: Anja Blažič, Rok Šmerc, Tamara Polajžer, Damijan Miklavčič, Lea Rems
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Electroporation
Sensitization
Electropermeabilization
Cell survival
Lidocaine
Melanoma cells
Online Access:https://doi.org/10.1038/s41598-025-11695-3
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