Evaluation of ior ® Leukocim efficacy on patients with Neutropenia.
<p><strong>Bakground:</strong> Neutropenia and infections are the most restrictive side effects in chemotherapy application. The granulocytic colonies stimulating factor activates the neutrophils, shortens the neutropenic period and can be effective against the potential risk of in...
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| Format: | Article |
| Language: | Spanish |
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Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2007-12-01
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| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/289 |
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| author | Ana María Ramos Cedeño Leslie Pérez Ruiz Julio Dámaso Fernández Águila Tamara Guerra Maritza Cabrera Zamora Hailen Bobillo López |
| author_facet | Ana María Ramos Cedeño Leslie Pérez Ruiz Julio Dámaso Fernández Águila Tamara Guerra Maritza Cabrera Zamora Hailen Bobillo López |
| author_sort | Ana María Ramos Cedeño |
| collection | DOAJ |
| description | <p><strong>Bakground:</strong> Neutropenia and infections are the most restrictive side effects in chemotherapy application. The granulocytic colonies stimulating factor activates the neutrophils, shortens the neutropenic period and can be effective against the potential risk of infection. There is a need of studies for its commercialization to endorse their effectiveness and security. <strong>Objective:</strong> To evaluate the impact of the G-CSF in primary and secondary prevention and neutropenia episodes, in onco-haematological patients in Cienfuegos. <strong>Method:</strong> 95 neutropenic episodes were studied, picked up in clinical histories and data collection notebooks belonging to 47 patients treated in the University Hospital ¨Dr. Gustavo Aldereguía Lima¨ in Cienfuegos and happened during one year (2005-2006). It was analyzed: demographic data, absolute neutrophils count values, number of administered doses, treatment regime and possible treatment interruptions <strong>Results:</strong> 50, 5% received treatment in an ambulatory way. There was treatment interruption in 9 episodes, 9,5% and the mean dose number administered to obtain the recovery of neutrophils absolute count was 6,69. <strong>Conclusions:</strong> The product was effective, sine the decrease of neutropenic episodes could be verified, as the elevation of neutrophil values in approximately one week, what allowed a better pursuit of chemotherapy to patients of the studied series.</p><p><strong>Abstract</strong></p><p>To demonstrate the effectiveness of Leukocim an open, phase IV clinical trial was designed, 39 patients from Cienfuegos were evaluated with 73 neutropenic episodes in primary or secondary prophylaxis or treatment, the demographic parameters behaved with an age 49.86 year old average, the predominant sex was the feminine 64.38%, 73.97% belonged to the white race, when the effectiveness was analyzed we obtained that 46.5% received the treatment in an ambulatory way, whereas 52.1% was hospitalized; one patient abandoned before beginning the treatment, the 12,3% of patients abandoned the study, the dose number received in order to correction CAN was between 3 and 7, behaving with a stocking of 1.26 before receiving the treatment and of 5.82 after the same one receiving the next cycle chemo y/o radiotherapy in time demonstrating this way the effectiveness of the product.</p> |
| format | Article |
| id | doaj-art-2a129308154e4e5b84019d48d692371f |
| institution | Kabale University |
| issn | 1727-897X |
| language | Spanish |
| publishDate | 2007-12-01 |
| publisher | Centro Provincial de Información de Ciencias Médicas. Cienfuegos |
| record_format | Article |
| series | Medisur |
| spelling | doaj-art-2a129308154e4e5b84019d48d692371f2025-01-30T21:28:39ZspaCentro Provincial de Información de Ciencias Médicas. CienfuegosMedisur1727-897X2007-12-01532326288Evaluation of ior ® Leukocim efficacy on patients with Neutropenia.Ana María Ramos CedeñoLeslie Pérez RuizJulio Dámaso Fernández ÁguilaTamara GuerraMaritza Cabrera ZamoraHailen Bobillo López<p><strong>Bakground:</strong> Neutropenia and infections are the most restrictive side effects in chemotherapy application. The granulocytic colonies stimulating factor activates the neutrophils, shortens the neutropenic period and can be effective against the potential risk of infection. There is a need of studies for its commercialization to endorse their effectiveness and security. <strong>Objective:</strong> To evaluate the impact of the G-CSF in primary and secondary prevention and neutropenia episodes, in onco-haematological patients in Cienfuegos. <strong>Method:</strong> 95 neutropenic episodes were studied, picked up in clinical histories and data collection notebooks belonging to 47 patients treated in the University Hospital ¨Dr. Gustavo Aldereguía Lima¨ in Cienfuegos and happened during one year (2005-2006). It was analyzed: demographic data, absolute neutrophils count values, number of administered doses, treatment regime and possible treatment interruptions <strong>Results:</strong> 50, 5% received treatment in an ambulatory way. There was treatment interruption in 9 episodes, 9,5% and the mean dose number administered to obtain the recovery of neutrophils absolute count was 6,69. <strong>Conclusions:</strong> The product was effective, sine the decrease of neutropenic episodes could be verified, as the elevation of neutrophil values in approximately one week, what allowed a better pursuit of chemotherapy to patients of the studied series.</p><p><strong>Abstract</strong></p><p>To demonstrate the effectiveness of Leukocim an open, phase IV clinical trial was designed, 39 patients from Cienfuegos were evaluated with 73 neutropenic episodes in primary or secondary prophylaxis or treatment, the demographic parameters behaved with an age 49.86 year old average, the predominant sex was the feminine 64.38%, 73.97% belonged to the white race, when the effectiveness was analyzed we obtained that 46.5% received the treatment in an ambulatory way, whereas 52.1% was hospitalized; one patient abandoned before beginning the treatment, the 12,3% of patients abandoned the study, the dose number received in order to correction CAN was between 3 and 7, behaving with a stocking of 1.26 before receiving the treatment and of 5.82 after the same one receiving the next cycle chemo y/o radiotherapy in time demonstrating this way the effectiveness of the product.</p>http://medisur.sld.cu/index.php/medisur/article/view/289evaluación de medicamentosneutropenianeutrófilosoncología por radiaciónhematologíaenfermedades hematológicasquimioterapia |
| spellingShingle | Ana María Ramos Cedeño Leslie Pérez Ruiz Julio Dámaso Fernández Águila Tamara Guerra Maritza Cabrera Zamora Hailen Bobillo López Evaluation of ior ® Leukocim efficacy on patients with Neutropenia. Medisur evaluación de medicamentos neutropenia neutrófilos oncología por radiación hematología enfermedades hematológicas quimioterapia |
| title | Evaluation of ior ® Leukocim efficacy on patients with Neutropenia. |
| title_full | Evaluation of ior ® Leukocim efficacy on patients with Neutropenia. |
| title_fullStr | Evaluation of ior ® Leukocim efficacy on patients with Neutropenia. |
| title_full_unstemmed | Evaluation of ior ® Leukocim efficacy on patients with Neutropenia. |
| title_short | Evaluation of ior ® Leukocim efficacy on patients with Neutropenia. |
| title_sort | evaluation of ior r leukocim efficacy on patients with neutropenia |
| topic | evaluación de medicamentos neutropenia neutrófilos oncología por radiación hematología enfermedades hematológicas quimioterapia |
| url | http://medisur.sld.cu/index.php/medisur/article/view/289 |
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