Tiny but mighty, an exploration of microbes and plants as sources of small novel bioactive compounds against invasive mycoses.
Despite the high mortality rate involved with invasive cerebral mycoses, there is a relative lack of research available around antifungals capable of crossing the blood brain barrier. In this study the metabolites of four plants (Crocus vernus, Miniature Narcissus (daffodil), Osmanthus delavayi and...
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| Format: | Article |
| Language: | English |
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Technological University Dublin
2023-12-01
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| Series: | SURE Journal: (Science Undergraduate Research Experience Journal) |
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| Online Access: | https://arrow.tudublin.ie/sure_j/vol5/iss1/3 |
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| author | Hannah Mai Peacock James Anthony O'Connor |
| author_facet | Hannah Mai Peacock James Anthony O'Connor |
| author_sort | Hannah Mai Peacock |
| collection | DOAJ |
| description | Despite the high mortality rate involved with invasive cerebral mycoses, there is a relative lack of research available around antifungals capable of crossing the blood brain barrier.
In this study the metabolites of four plants (Crocus vernus, Miniature Narcissus (daffodil), Osmanthus delavayi and Taraxacum officinale (common dandelion)) and two bacteria (Lacticaseibacillus paracasei and Staphylococcus epidermidis) were extracted and assayed for antifungal activity against Candida albicans and Saccharomyces cerevisiae. Thin layer chromatography and bioautography were then employed to assess the activity of the constituent components of sources showing antifungal activity.
Metabolites of S.epidermidis, and extracts of miniature Narcissus and Taraxacum officinal demonstrated no antifungal activity, metabolites of Lacticaseibacillus paracasei demonstrated variable antifungal activity and extracts of Osmanthus delavayi demonstrated previously unreported antifungal activity, although there were issues with repeatability.
Osmanthus delavayi warrants further study, with an aim to separate out each component, test it for bioactivity and/or asses for the presence of synergism between two or more components, determine their interactions with the blood brain barrier and any potential toxicities and therefore assess the therapeutic potential. |
| format | Article |
| id | doaj-art-2a0f42be259e47fab5aa30b09118e2c1 |
| institution | Kabale University |
| issn | 2990-8167 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Technological University Dublin |
| record_format | Article |
| series | SURE Journal: (Science Undergraduate Research Experience Journal) |
| spelling | doaj-art-2a0f42be259e47fab5aa30b09118e2c12025-01-31T10:28:14ZengTechnological University DublinSURE Journal: (Science Undergraduate Research Experience Journal)2990-81672023-12-015110.21427/45q2-g772Tiny but mighty, an exploration of microbes and plants as sources of small novel bioactive compounds against invasive mycoses.Hannah Mai Peacock0James Anthony O'Connor1Munster Technological UniversityMunster Technological UniversityDespite the high mortality rate involved with invasive cerebral mycoses, there is a relative lack of research available around antifungals capable of crossing the blood brain barrier. In this study the metabolites of four plants (Crocus vernus, Miniature Narcissus (daffodil), Osmanthus delavayi and Taraxacum officinale (common dandelion)) and two bacteria (Lacticaseibacillus paracasei and Staphylococcus epidermidis) were extracted and assayed for antifungal activity against Candida albicans and Saccharomyces cerevisiae. Thin layer chromatography and bioautography were then employed to assess the activity of the constituent components of sources showing antifungal activity. Metabolites of S.epidermidis, and extracts of miniature Narcissus and Taraxacum officinal demonstrated no antifungal activity, metabolites of Lacticaseibacillus paracasei demonstrated variable antifungal activity and extracts of Osmanthus delavayi demonstrated previously unreported antifungal activity, although there were issues with repeatability. Osmanthus delavayi warrants further study, with an aim to separate out each component, test it for bioactivity and/or asses for the presence of synergism between two or more components, determine their interactions with the blood brain barrier and any potential toxicities and therefore assess the therapeutic potential.https://arrow.tudublin.ie/sure_j/vol5/iss1/3blood-brain barriercentral nervous systeminvasive mycosesthin layer chromatographymethanol extractioncrocus vernusnarcissusosmanthus delavyitaraxum oficinaledandeliondaffodilstaphylococcus epidermidislactoxaseibacillus paracaseicandida albicanssaccharmocyes cerevisiae |
| spellingShingle | Hannah Mai Peacock James Anthony O'Connor Tiny but mighty, an exploration of microbes and plants as sources of small novel bioactive compounds against invasive mycoses. SURE Journal: (Science Undergraduate Research Experience Journal) blood-brain barrier central nervous system invasive mycoses thin layer chromatography methanol extraction crocus vernus narcissus osmanthus delavyi taraxum oficinale dandelion daffodil staphylococcus epidermidis lactoxaseibacillus paracasei candida albicans saccharmocyes cerevisiae |
| title | Tiny but mighty, an exploration of microbes and plants as sources of small novel bioactive compounds against invasive mycoses. |
| title_full | Tiny but mighty, an exploration of microbes and plants as sources of small novel bioactive compounds against invasive mycoses. |
| title_fullStr | Tiny but mighty, an exploration of microbes and plants as sources of small novel bioactive compounds against invasive mycoses. |
| title_full_unstemmed | Tiny but mighty, an exploration of microbes and plants as sources of small novel bioactive compounds against invasive mycoses. |
| title_short | Tiny but mighty, an exploration of microbes and plants as sources of small novel bioactive compounds against invasive mycoses. |
| title_sort | tiny but mighty an exploration of microbes and plants as sources of small novel bioactive compounds against invasive mycoses |
| topic | blood-brain barrier central nervous system invasive mycoses thin layer chromatography methanol extraction crocus vernus narcissus osmanthus delavyi taraxum oficinale dandelion daffodil staphylococcus epidermidis lactoxaseibacillus paracasei candida albicans saccharmocyes cerevisiae |
| url | https://arrow.tudublin.ie/sure_j/vol5/iss1/3 |
| work_keys_str_mv | AT hannahmaipeacock tinybutmightyanexplorationofmicrobesandplantsassourcesofsmallnovelbioactivecompoundsagainstinvasivemycoses AT jamesanthonyoconnor tinybutmightyanexplorationofmicrobesandplantsassourcesofsmallnovelbioactivecompoundsagainstinvasivemycoses |