Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation

Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation

Abstract Background Hypertrophic scar (HS) is a common fibrotic skin disorder characterized by the excessive deposition of extracellular matrix (ECM). Fibroblasts are the most important effector cells involved in HS formation. Currently no satisfactory treatment has been developed. Methods The impac...

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Bibliographic Details
Main Authors: Wei Xu, Hao Lv, Yaxin Xue, Xiaofeng Shi, Shaotian Fu, Xiaojun Li, Chuandong Wang, Danyang Zhao, Dong Han
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Biology Direct
Subjects:
Hypertrophic scar
Cathepsin B
Ferroptosis
Long-read sequencing
Fraxinellone
Online Access:https://doi.org/10.1186/s13062-025-00610-5
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