MicroRNA-499a in heart diseases: prospects for use in diagnostics. A review
Cardiac-specific (or myomiR) miRNA-499a (miR-499a) is a small (21–22 bp) non-coding RNA that is involved in the regulation of cardiac function both under normal and in various pathological conditions. Every year new studies expand the range of known biological processes that are regulated by miR-499...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2025-01-01
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| Series: | Терапевтический архив |
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| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/634674/194496 |
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| author | Maria V. Pisklova Natalia M. Baulina Ivan S. Kiselev Olga O. Favorova |
| author_facet | Maria V. Pisklova Natalia M. Baulina Ivan S. Kiselev Olga O. Favorova |
| author_sort | Maria V. Pisklova |
| collection | DOAJ |
| description | Cardiac-specific (or myomiR) miRNA-499a (miR-499a) is a small (21–22 bp) non-coding RNA that is involved in the regulation of cardiac function both under normal and in various pathological conditions. Every year new studies expand the range of known biological processes that are regulated by miR-499a in the heart. In acute and chronic cardiovascular diseases accompanied by cardiomyocyte damage, miR-499a enters the bloodstream and can circulate there for a long time. At the same time, it is detected in plasma significantly earlier than traditional protein biomarkers, which makes it a new promising biomarker for early diagnosis and prognosis of heart diseases. This review describes the functions of human miR-499a and its involvement in the development of heart diseases. The data indicating the high diagnostic value of this miRNA in blood are presented. |
| format | Article |
| id | doaj-art-2a0c1d645f3e46c8ad0b7ea14011b21f |
| institution | OA Journals |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| publishDate | 2025-01-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj-art-2a0c1d645f3e46c8ad0b7ea14011b21f2025-08-20T02:25:44Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422025-01-0197435335910.26442/00403660.2025.04.20316178575MicroRNA-499a in heart diseases: prospects for use in diagnostics. A reviewMaria V. Pisklova0https://orcid.org/0000-0001-7844-3328Natalia M. Baulina1https://orcid.org/0000-0001-8767-2958Ivan S. Kiselev2https://orcid.org/0000-0003-3366-4113Olga O. Favorova3https://orcid.org/0000-0002-5271-6698Pirogov Russian National Research Medical University (Pirogov University)Pirogov Russian National Research Medical University (Pirogov University)Pirogov Russian National Research Medical University (Pirogov University)Pirogov Russian National Research Medical University (Pirogov University)Cardiac-specific (or myomiR) miRNA-499a (miR-499a) is a small (21–22 bp) non-coding RNA that is involved in the regulation of cardiac function both under normal and in various pathological conditions. Every year new studies expand the range of known biological processes that are regulated by miR-499a in the heart. In acute and chronic cardiovascular diseases accompanied by cardiomyocyte damage, miR-499a enters the bloodstream and can circulate there for a long time. At the same time, it is detected in plasma significantly earlier than traditional protein biomarkers, which makes it a new promising biomarker for early diagnosis and prognosis of heart diseases. This review describes the functions of human miR-499a and its involvement in the development of heart diseases. The data indicating the high diagnostic value of this miRNA in blood are presented.https://ter-arkhiv.ru/0040-3660/article/viewFile/634674/194496micrornamir-499acardiovascular systemheart diseasesgene expressionexpression regulation |
| spellingShingle | Maria V. Pisklova Natalia M. Baulina Ivan S. Kiselev Olga O. Favorova MicroRNA-499a in heart diseases: prospects for use in diagnostics. A review Терапевтический архив microrna mir-499a cardiovascular system heart diseases gene expression expression regulation |
| title | MicroRNA-499a in heart diseases: prospects for use in diagnostics. A review |
| title_full | MicroRNA-499a in heart diseases: prospects for use in diagnostics. A review |
| title_fullStr | MicroRNA-499a in heart diseases: prospects for use in diagnostics. A review |
| title_full_unstemmed | MicroRNA-499a in heart diseases: prospects for use in diagnostics. A review |
| title_short | MicroRNA-499a in heart diseases: prospects for use in diagnostics. A review |
| title_sort | microrna 499a in heart diseases prospects for use in diagnostics a review |
| topic | microrna mir-499a cardiovascular system heart diseases gene expression expression regulation |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/634674/194496 |
| work_keys_str_mv | AT mariavpisklova microrna499ainheartdiseasesprospectsforuseindiagnosticsareview AT nataliambaulina microrna499ainheartdiseasesprospectsforuseindiagnosticsareview AT ivanskiselev microrna499ainheartdiseasesprospectsforuseindiagnosticsareview AT olgaofavorova microrna499ainheartdiseasesprospectsforuseindiagnosticsareview |