The efficacy and safety of chemoimmunotherapy in patients with MSI-L/MSS/pMMR status metastatic colorectal cancer: a systematic review and meta-analysis of randomized controlled trials

The efficacy and safety of chemoimmunotherapy in patients with MSI-L/MSS/pMMR status metastatic colorectal cancer: a systematic review and meta-analysis of randomized controlled trials

BackgroundColorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, necessitating innovative therapeutic approaches. Most patients with CRC exhibit microsatellite instability-low/stable (MSI-L/MSS) or proficient mismatch repair (pMMR) status, with chemotherapy being the...

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Bibliographic Details
Main Authors: Qi-Jing Zhang, Jia-xin Zhou, Da-hai Hu, Jing-hua Pan, Si-min Luo, Qi Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
immune checkpoint inhibitors
efficacy
safety
meta-analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1514485/full
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