PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA. REVIEW
Advances in understanding of the molecular mechanisms underlying oral squamous cell carcinoma (OSCC) have resulted in an increasing number of molecules-biomarkers that can be used for prediction of behaviour of this disease to achieve the above objective.We identified and classified 24 molecular bio...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-04-01
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| Series: | Опухоли головы и шеи |
| Subjects: | |
| Online Access: | https://ogsh.abvpress.ru/jour/article/view/111 |
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| author | A. V. Ignatova A. M. Mudunov M. N. Narimanov |
| author_facet | A. V. Ignatova A. M. Mudunov M. N. Narimanov |
| author_sort | A. V. Ignatova |
| collection | DOAJ |
| description | Advances in understanding of the molecular mechanisms underlying oral squamous cell carcinoma (OSCC) have resulted in an increasing number of molecules-biomarkers that can be used for prediction of behaviour of this disease to achieve the above objective.We identified and classified 24 molecular biomarkers into five groups based on their biological functions: 1) cell cycle acceleration and proliferation; 2) hypoxia-inducible factors; 3) tumour suppression and apoptosis; 4) angiogenesis; 5) cell adhesion and matrix degradation. We considered articles published in PubMed-indexed journals over the past 8 years and conducted a literature review of studies examining the role of immunohistochemistry-based protein biomarkers in predicting OSCC outcome. |
| format | Article |
| id | doaj-art-2a0abf293c144974ae22f03280444fc8 |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2015-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-2a0abf293c144974ae22f03280444fc82025-08-20T03:37:43ZrusABV-pressОпухоли головы и шеи2222-14682411-46342015-04-0104283310.17650/2222-1468-2014-0-4-28-33111PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA. REVIEWA. V. Ignatova0A. M. Mudunov1M. N. Narimanov2Russian Medical Academy of Post-Graduate Education., MoscowResearch Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, MoscowResearch Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, MoscowAdvances in understanding of the molecular mechanisms underlying oral squamous cell carcinoma (OSCC) have resulted in an increasing number of molecules-biomarkers that can be used for prediction of behaviour of this disease to achieve the above objective.We identified and classified 24 molecular biomarkers into five groups based on their biological functions: 1) cell cycle acceleration and proliferation; 2) hypoxia-inducible factors; 3) tumour suppression and apoptosis; 4) angiogenesis; 5) cell adhesion and matrix degradation. We considered articles published in PubMed-indexed journals over the past 8 years and conducted a literature review of studies examining the role of immunohistochemistry-based protein biomarkers in predicting OSCC outcome.https://ogsh.abvpress.ru/jour/article/view/111oral squamous cell carcinoma, biomarker, survival, prognosis, outcome, immunohistochemistry, cell cycle, hypoxia, apoptosis, angiogenesis, adhesion |
| spellingShingle | A. V. Ignatova A. M. Mudunov M. N. Narimanov PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA. REVIEW Опухоли головы и шеи oral squamous cell carcinoma, biomarker, survival, prognosis, outcome, immunohistochemistry, cell cycle, hypoxia, apoptosis, angiogenesis, adhesion |
| title | PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA. REVIEW |
| title_full | PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA. REVIEW |
| title_fullStr | PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA. REVIEW |
| title_full_unstemmed | PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA. REVIEW |
| title_short | PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA. REVIEW |
| title_sort | prognostic significance of biomarkers in oral squamous cell carcinoma review |
| topic | oral squamous cell carcinoma, biomarker, survival, prognosis, outcome, immunohistochemistry, cell cycle, hypoxia, apoptosis, angiogenesis, adhesion |
| url | https://ogsh.abvpress.ru/jour/article/view/111 |
| work_keys_str_mv | AT avignatova prognosticsignificanceofbiomarkersinoralsquamouscellcarcinomareview AT ammudunov prognosticsignificanceofbiomarkersinoralsquamouscellcarcinomareview AT mnnarimanov prognosticsignificanceofbiomarkersinoralsquamouscellcarcinomareview |