Comparative study between ultrasound-guided closed pleural biopsy and thoracoscopic pleural biopsy in undiagnosed exudative pleural effusions
Pleural biopsies are often required to establish a diagnosis in exudative pleural effusions, which remain undiagnosed after initial pleural fluid analysis. Medical thoracoscopy offers a high diagnostic yield but has limited availability in resource-constrained settings. This prospective comparative...
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PAGEPress Publications
2025-03-01
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| Series: | Monaldi Archives for Chest Disease |
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| Online Access: | https://www.monaldi-archives.org/macd/article/view/3361 |
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| author | Sreyas Sharma Nitesh Gupta Pranav Ish Rajnish Kaushik Neeraj Kumar Gupta Tanmaya Talukdar Rohit Kumar |
| author_facet | Sreyas Sharma Nitesh Gupta Pranav Ish Rajnish Kaushik Neeraj Kumar Gupta Tanmaya Talukdar Rohit Kumar |
| author_sort | Sreyas Sharma |
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Pleural biopsies are often required to establish a diagnosis in exudative pleural effusions, which remain undiagnosed after initial pleural fluid analysis. Medical thoracoscopy offers a high diagnostic yield but has limited availability in resource-constrained settings. This prospective comparative study evaluated the diagnostic yield between ultrasound-guided closed pleural biopsy and medical thoracoscopy among patients with undiagnosed exudative pleural effusions with pleural-based lesions at least 10 mm in size. Both groups achieved an equal diagnostic yield of 92% despite fewer biopsy specimens being taken in the ultrasound-guided biopsy group (4.52±0.65) compared to the thoracoscopic group (7.8±1) (p<0.0001). In conclusion, ultrasound-guided closed pleural biopsy is a suitable alternative to medical thoracoscopy in patients with undiagnosed exudative pleural effusion having pleural thickening or nodularity of at least 10 mm in size in terms of having similar diagnostic yield as compared to medical thoracoscopy.
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| format | Article |
| id | doaj-art-2a01f50d060341d49e0c364de92d3c42 |
| institution | OA Journals |
| issn | 1122-0643 2532-5264 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj-art-2a01f50d060341d49e0c364de92d3c422025-08-20T02:06:46ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642025-03-0110.4081/monaldi.2025.3361Comparative study between ultrasound-guided closed pleural biopsy and thoracoscopic pleural biopsy in undiagnosed exudative pleural effusionsSreyas Sharma0https://orcid.org/0009-0005-8156-5381Nitesh Gupta1https://orcid.org/0000-0002-5842-5584Pranav Ish2Rajnish Kaushik3https://orcid.org/0009-0008-3985-4659Neeraj Kumar Gupta4Tanmaya Talukdar5https://orcid.org/0000-0002-4600-4571Rohit Kumar6Department of Pulmonary Medicine, Critical Care and Sleep Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New DelhiDepartment of Pulmonary Medicine, Critical Care and Sleep Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New DelhiDepartment of Pulmonary Medicine, Critical Care and Sleep Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New DelhiDepartment of Pulmonary Medicine, Critical Care and Sleep Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New DelhiDepartment of Pulmonary Medicine, Critical Care and Sleep Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New DelhiDepartment of Pulmonary Medicine, Critical Care and Sleep Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New DelhiDepartment of Pulmonary Medicine, Critical Care and Sleep Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi Pleural biopsies are often required to establish a diagnosis in exudative pleural effusions, which remain undiagnosed after initial pleural fluid analysis. Medical thoracoscopy offers a high diagnostic yield but has limited availability in resource-constrained settings. This prospective comparative study evaluated the diagnostic yield between ultrasound-guided closed pleural biopsy and medical thoracoscopy among patients with undiagnosed exudative pleural effusions with pleural-based lesions at least 10 mm in size. Both groups achieved an equal diagnostic yield of 92% despite fewer biopsy specimens being taken in the ultrasound-guided biopsy group (4.52±0.65) compared to the thoracoscopic group (7.8±1) (p<0.0001). In conclusion, ultrasound-guided closed pleural biopsy is a suitable alternative to medical thoracoscopy in patients with undiagnosed exudative pleural effusion having pleural thickening or nodularity of at least 10 mm in size in terms of having similar diagnostic yield as compared to medical thoracoscopy. https://www.monaldi-archives.org/macd/article/view/3361Ultrasound-guided pleural biopsyimage-guided pleural biopsyclosed pleural biopsymedical thoracoscopyexudative pleural effusion |
| spellingShingle | Sreyas Sharma Nitesh Gupta Pranav Ish Rajnish Kaushik Neeraj Kumar Gupta Tanmaya Talukdar Rohit Kumar Comparative study between ultrasound-guided closed pleural biopsy and thoracoscopic pleural biopsy in undiagnosed exudative pleural effusions Monaldi Archives for Chest Disease Ultrasound-guided pleural biopsy image-guided pleural biopsy closed pleural biopsy medical thoracoscopy exudative pleural effusion |
| title | Comparative study between ultrasound-guided closed pleural biopsy and thoracoscopic pleural biopsy in undiagnosed exudative pleural effusions |
| title_full | Comparative study between ultrasound-guided closed pleural biopsy and thoracoscopic pleural biopsy in undiagnosed exudative pleural effusions |
| title_fullStr | Comparative study between ultrasound-guided closed pleural biopsy and thoracoscopic pleural biopsy in undiagnosed exudative pleural effusions |
| title_full_unstemmed | Comparative study between ultrasound-guided closed pleural biopsy and thoracoscopic pleural biopsy in undiagnosed exudative pleural effusions |
| title_short | Comparative study between ultrasound-guided closed pleural biopsy and thoracoscopic pleural biopsy in undiagnosed exudative pleural effusions |
| title_sort | comparative study between ultrasound guided closed pleural biopsy and thoracoscopic pleural biopsy in undiagnosed exudative pleural effusions |
| topic | Ultrasound-guided pleural biopsy image-guided pleural biopsy closed pleural biopsy medical thoracoscopy exudative pleural effusion |
| url | https://www.monaldi-archives.org/macd/article/view/3361 |
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