The challenge of managing isolated STIC lesions: A single-center experience
Objectives: High-grade serous carcinoma (HGSC) arise from serous tubal intraepithelial carcinoma (STIC) lesions, a precursor that develops from the fallopian tube epithelium. Patients with incidental isolated STIC lesions found on salpingectomy specimen have up to 25% risk of developing HGSC or peri...
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Elsevier
2025-04-01
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| Series: | Gynecologic Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578925000414 |
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| author | Renata Sabelli Basile Tessier-Cloutier Lili Fu Shuk On Annie Leung Xing Zeng Reitan Ribeiro Victoria Mandilaras Lucy Gilbert Laurence Bernard |
| author_facet | Renata Sabelli Basile Tessier-Cloutier Lili Fu Shuk On Annie Leung Xing Zeng Reitan Ribeiro Victoria Mandilaras Lucy Gilbert Laurence Bernard |
| author_sort | Renata Sabelli |
| collection | DOAJ |
| description | Objectives: High-grade serous carcinoma (HGSC) arise from serous tubal intraepithelial carcinoma (STIC) lesions, a precursor that develops from the fallopian tube epithelium. Patients with incidental isolated STIC lesions found on salpingectomy specimen have up to 25% risk of developing HGSC or peritoneal carcinomatosis in the future, yet there is no established consensus to guide management. Methods: This retrospective case series includes patients diagnosed with isolated STIC lesions between April 2017 and January 2024. Patient data was extracted from clinical and pathological databases. Results: During the study period, 10 patients were diagnosed with an isolated STIC lesion. The fallopian tubes were removed either as part of a hysterectomy for endometrial cancer (n = 3); a prophylactic risk-reducing surgery for BRCA1 or BRCA2 mutation (n = 3); or a benign gynecologic condition (n = 4). The median age of the patients was 64 years (range: 53–80). Among patients who underwent genetic testing (n = 9), only three were found to have a deleterious germline mutation in BRCA1 or BRCA2. The patients either received adjuvant chemotherapy (n = 5) or underwent active surveillance (n = 5). One surveillance patient was managed with completion bilateral oophorectomy and omentectomy. Median number of chemotherapy cycles was four (range 4–6 cycles). The median follow-up was 27 months (range: 5–83 months). One patient under active surveillance was diagnosed with peritoneal carcinomatosis 5 years after initial diagnosis of STIC whereas none recurred in the chemotherapy group. Conclusion: The wide variety of treatment approaches we observed highlights a need for more data on this entity to support management guidelines. |
| format | Article |
| id | doaj-art-2a0197f6dfb546c19d48da26b9452400 |
| institution | OA Journals |
| issn | 2352-5789 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj-art-2a0197f6dfb546c19d48da26b94524002025-08-20T02:17:29ZengElsevierGynecologic Oncology Reports2352-57892025-04-015810171610.1016/j.gore.2025.101716The challenge of managing isolated STIC lesions: A single-center experienceRenata Sabelli0Basile Tessier-Cloutier1Lili Fu2Shuk On Annie Leung3Xing Zeng4Reitan Ribeiro5Victoria Mandilaras6Lucy Gilbert7Laurence Bernard8Faculty of Medicine and Health Sciences, McGill University, CanadaFaculty of Medicine and Health Sciences, McGill University, Canada; Department of Pathology, McGill University, CanadaFaculty of Medicine and Health Sciences, McGill University, Canada; Department of Pathology, McGill University, CanadaFaculty of Medicine and Health Sciences, McGill University, Canada; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, McGill University, CanadaFaculty of Medicine and Health Sciences, McGill University, Canada; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, McGill University, CanadaFaculty of Medicine and Health Sciences, McGill University, Canada; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, McGill University, CanadaFaculty of Medicine and Health Sciences, McGill University, Canada; Gerald Bronfman Department of Oncology, McGill University, CanadaFaculty of Medicine and Health Sciences, McGill University, Canada; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, McGill University, Canada; Gerald Bronfman Department of Oncology, McGill University, CanadaFaculty of Medicine and Health Sciences, McGill University, Canada; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, McGill University, Canada; Corresponding author at: 1001 Décarie Bvd, Montréal, QC H4A 3J1, Canada.Objectives: High-grade serous carcinoma (HGSC) arise from serous tubal intraepithelial carcinoma (STIC) lesions, a precursor that develops from the fallopian tube epithelium. Patients with incidental isolated STIC lesions found on salpingectomy specimen have up to 25% risk of developing HGSC or peritoneal carcinomatosis in the future, yet there is no established consensus to guide management. Methods: This retrospective case series includes patients diagnosed with isolated STIC lesions between April 2017 and January 2024. Patient data was extracted from clinical and pathological databases. Results: During the study period, 10 patients were diagnosed with an isolated STIC lesion. The fallopian tubes were removed either as part of a hysterectomy for endometrial cancer (n = 3); a prophylactic risk-reducing surgery for BRCA1 or BRCA2 mutation (n = 3); or a benign gynecologic condition (n = 4). The median age of the patients was 64 years (range: 53–80). Among patients who underwent genetic testing (n = 9), only three were found to have a deleterious germline mutation in BRCA1 or BRCA2. The patients either received adjuvant chemotherapy (n = 5) or underwent active surveillance (n = 5). One surveillance patient was managed with completion bilateral oophorectomy and omentectomy. Median number of chemotherapy cycles was four (range 4–6 cycles). The median follow-up was 27 months (range: 5–83 months). One patient under active surveillance was diagnosed with peritoneal carcinomatosis 5 years after initial diagnosis of STIC whereas none recurred in the chemotherapy group. Conclusion: The wide variety of treatment approaches we observed highlights a need for more data on this entity to support management guidelines.http://www.sciencedirect.com/science/article/pii/S2352578925000414Adjuvant ChemotherapyHigh-grade serous ovarian cancer (HGSC)Management & Treatment.Peritoneal carcinomatosis (PC)Serous Tubal Intraepithelial Carcinoma (STIC) |
| spellingShingle | Renata Sabelli Basile Tessier-Cloutier Lili Fu Shuk On Annie Leung Xing Zeng Reitan Ribeiro Victoria Mandilaras Lucy Gilbert Laurence Bernard The challenge of managing isolated STIC lesions: A single-center experience Gynecologic Oncology Reports Adjuvant Chemotherapy High-grade serous ovarian cancer (HGSC) Management & Treatment. Peritoneal carcinomatosis (PC) Serous Tubal Intraepithelial Carcinoma (STIC) |
| title | The challenge of managing isolated STIC lesions: A single-center experience |
| title_full | The challenge of managing isolated STIC lesions: A single-center experience |
| title_fullStr | The challenge of managing isolated STIC lesions: A single-center experience |
| title_full_unstemmed | The challenge of managing isolated STIC lesions: A single-center experience |
| title_short | The challenge of managing isolated STIC lesions: A single-center experience |
| title_sort | challenge of managing isolated stic lesions a single center experience |
| topic | Adjuvant Chemotherapy High-grade serous ovarian cancer (HGSC) Management & Treatment. Peritoneal carcinomatosis (PC) Serous Tubal Intraepithelial Carcinoma (STIC) |
| url | http://www.sciencedirect.com/science/article/pii/S2352578925000414 |
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