Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis
T-helper-17 (Th17) cells are implicated in a number of inflammatory disorders including rheumatoid arthritis. Antagonism of Th17 cells is a treatment option for arthritis. Here, we report that Baicalin, a compound isolated from the Chinese herb Huangqin (Scutellaria baicalensis Georgi), relieved an...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/268065 |
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| author | Xue Yang Ji Yang Hejian Zou |
| author_facet | Xue Yang Ji Yang Hejian Zou |
| author_sort | Xue Yang |
| collection | DOAJ |
| description | T-helper-17 (Th17) cells are implicated in a number of inflammatory disorders including rheumatoid arthritis. Antagonism of Th17 cells is a treatment option for arthritis. Here, we report that Baicalin, a compound isolated from the Chinese herb Huangqin (Scutellaria baicalensis Georgi), relieved ankle swelling and protected the joint against inflammatory destruction in a murine adjuvant-induced arthritis model. Baicalin inhibited splenic Th17 cell population expansion in vivo. Baicalin prevented interleukin- (IL-) 17-mediated lymphocyte adhesion to cultured synoviocytes. Baicalin also blocked IL-17-induced intercellular adhesion molecule 1, vascular cell adhesion molecule 1, IL-6, and tumor necrosis factor-alpha mRNA expression in cultured synoviocytes. Collectively, these findings suggest that Baicalin downregulates the joint inflammation caused by IL-17, which is likely produced by an expanded population of splenic Th17 cells in experimental arthritis. Baicalin might be a promising novel therapeutic agent for treating rheumatoid arthritis in humans. |
| format | Article |
| id | doaj-art-2a006ceed8de4eb298ec1d6499a454bd |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-2a006ceed8de4eb298ec1d6499a454bd2025-08-20T03:54:37ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/268065268065Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced ArthritisXue Yang0Ji Yang1Hejian Zou2Division of Rheumatology, Huashan Hospital, Fudan University, 12 Wulumuqizhong Road, Shanghai 200040, ChinaDepartment of Dermatology, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDivision of Rheumatology, Huashan Hospital, Fudan University, 12 Wulumuqizhong Road, Shanghai 200040, ChinaT-helper-17 (Th17) cells are implicated in a number of inflammatory disorders including rheumatoid arthritis. Antagonism of Th17 cells is a treatment option for arthritis. Here, we report that Baicalin, a compound isolated from the Chinese herb Huangqin (Scutellaria baicalensis Georgi), relieved ankle swelling and protected the joint against inflammatory destruction in a murine adjuvant-induced arthritis model. Baicalin inhibited splenic Th17 cell population expansion in vivo. Baicalin prevented interleukin- (IL-) 17-mediated lymphocyte adhesion to cultured synoviocytes. Baicalin also blocked IL-17-induced intercellular adhesion molecule 1, vascular cell adhesion molecule 1, IL-6, and tumor necrosis factor-alpha mRNA expression in cultured synoviocytes. Collectively, these findings suggest that Baicalin downregulates the joint inflammation caused by IL-17, which is likely produced by an expanded population of splenic Th17 cells in experimental arthritis. Baicalin might be a promising novel therapeutic agent for treating rheumatoid arthritis in humans.http://dx.doi.org/10.1155/2013/268065 |
| spellingShingle | Xue Yang Ji Yang Hejian Zou Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis Clinical and Developmental Immunology |
| title | Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis |
| title_full | Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis |
| title_fullStr | Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis |
| title_full_unstemmed | Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis |
| title_short | Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis |
| title_sort | baicalin inhibits il 17 mediated joint inflammation in murine adjuvant induced arthritis |
| url | http://dx.doi.org/10.1155/2013/268065 |
| work_keys_str_mv | AT xueyang baicalininhibitsil17mediatedjointinflammationinmurineadjuvantinducedarthritis AT jiyang baicalininhibitsil17mediatedjointinflammationinmurineadjuvantinducedarthritis AT hejianzou baicalininhibitsil17mediatedjointinflammationinmurineadjuvantinducedarthritis |