The Role of Exercise in Regulating the Generation of Extracellular Vesicles in Cardiovascular Diseases
Extracellular vesicles (EVs) are nanoscale vesicles released by cells, which play an important role in intercellular communication by transporting proteins, lipids, nucleic acids, and other molecules. Different intensities of exercise can induce the release of EVs from cells and tissues, such as end...
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| Format: | Article |
| Language: | English |
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IMR Press
2024-11-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/25/11/10.31083/j.rcm2511392 |
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| author | Peng Shen Yue Qiu Yan-Yan Sun Yue-Ying Jiang Xiu-Mei Guan Min Cheng Yan-Xia Wang |
| author_facet | Peng Shen Yue Qiu Yan-Yan Sun Yue-Ying Jiang Xiu-Mei Guan Min Cheng Yan-Xia Wang |
| author_sort | Peng Shen |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are nanoscale vesicles released by cells, which play an important role in intercellular communication by transporting proteins, lipids, nucleic acids, and other molecules. Different intensities of exercise can induce the release of EVs from cells and tissues, such as endothelial cells, skeletal muscle and adipose tissue, hepatocytes, immune cells, and neuronal cells. Exercise-induced EVs exert cardiovascular protective effects such as anti-inflammatory and anti-oxidative by altering their contents. This paper reviews the cell and tissue sources of EVs induced by exercise of different intensities, the regulatory effects of different exercise intensities on EVs, and their mechanisms of action in cardiovascular diseases. The aim is to provide new insights for the treatment of cardiovascular diseases and offer scientific evidence for the construction of engineered EVs mimicking the effects of exercise. |
| format | Article |
| id | doaj-art-29ffd3744f0f4051af9cf1513e8fab9e |
| institution | OA Journals |
| issn | 1530-6550 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-29ffd3744f0f4051af9cf1513e8fab9e2025-08-20T02:07:34ZengIMR PressReviews in Cardiovascular Medicine1530-65502024-11-01251139210.31083/j.rcm2511392S1530-6550(24)01584-9The Role of Exercise in Regulating the Generation of Extracellular Vesicles in Cardiovascular DiseasesPeng Shen0Yue Qiu1Yan-Yan Sun2Yue-Ying Jiang3Xiu-Mei Guan4Min Cheng5Yan-Xia Wang6School of Rehabilitation Medicine, Shandong Second Medical University, 261053 Weifang, Shandong, ChinaSchool of Rehabilitation Medicine, Shandong Second Medical University, 261053 Weifang, Shandong, ChinaSchool of Rehabilitation Medicine, Shandong Second Medical University, 261053 Weifang, Shandong, ChinaSchool of Rehabilitation Medicine, Shandong Second Medical University, 261053 Weifang, Shandong, ChinaSchool of Basic Medical Sciences, Shandong Second Medical University, 261053 Weifang, Shandong, ChinaSchool of Basic Medical Sciences, Shandong Second Medical University, 261053 Weifang, Shandong, ChinaSchool of Rehabilitation Medicine, Shandong Second Medical University, 261053 Weifang, Shandong, ChinaExtracellular vesicles (EVs) are nanoscale vesicles released by cells, which play an important role in intercellular communication by transporting proteins, lipids, nucleic acids, and other molecules. Different intensities of exercise can induce the release of EVs from cells and tissues, such as endothelial cells, skeletal muscle and adipose tissue, hepatocytes, immune cells, and neuronal cells. Exercise-induced EVs exert cardiovascular protective effects such as anti-inflammatory and anti-oxidative by altering their contents. This paper reviews the cell and tissue sources of EVs induced by exercise of different intensities, the regulatory effects of different exercise intensities on EVs, and their mechanisms of action in cardiovascular diseases. The aim is to provide new insights for the treatment of cardiovascular diseases and offer scientific evidence for the construction of engineered EVs mimicking the effects of exercise.https://www.imrpress.com/journal/RCM/25/11/10.31083/j.rcm2511392evsexercisecardiovascular diseasesmirna |
| spellingShingle | Peng Shen Yue Qiu Yan-Yan Sun Yue-Ying Jiang Xiu-Mei Guan Min Cheng Yan-Xia Wang The Role of Exercise in Regulating the Generation of Extracellular Vesicles in Cardiovascular Diseases Reviews in Cardiovascular Medicine evs exercise cardiovascular diseases mirna |
| title | The Role of Exercise in Regulating the Generation of Extracellular Vesicles in Cardiovascular Diseases |
| title_full | The Role of Exercise in Regulating the Generation of Extracellular Vesicles in Cardiovascular Diseases |
| title_fullStr | The Role of Exercise in Regulating the Generation of Extracellular Vesicles in Cardiovascular Diseases |
| title_full_unstemmed | The Role of Exercise in Regulating the Generation of Extracellular Vesicles in Cardiovascular Diseases |
| title_short | The Role of Exercise in Regulating the Generation of Extracellular Vesicles in Cardiovascular Diseases |
| title_sort | role of exercise in regulating the generation of extracellular vesicles in cardiovascular diseases |
| topic | evs exercise cardiovascular diseases mirna |
| url | https://www.imrpress.com/journal/RCM/25/11/10.31083/j.rcm2511392 |
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