Microwave‐Assisted Tragacanth Gum–Based Grafted Silver Nanocomposite Hydrogel for Sustained Release Formulations of Diclofenac Sodium and Antibacterial Assay
ABSTRACT In this work, novel tragacanth gum‐graft‐poly(2‐acrylamido‐2‐methylpropanesulfonic acid) (TG‐g‐PAMPS) hydrogel was synthesized via free radical copolymerization of TG, 2‐acrylamido‐2‐methylpropanesulfonic acid by using ammonium peroxodisulfate and N,N‐methylene‐bis‐acrylamide under microwav...
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Wiley-VCH
2024-12-01
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| Series: | Nano Select |
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| Online Access: | https://doi.org/10.1002/nano.202300200 |
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| author | Sharanappa Chapi Gangadhar Babaladimath M. V. Murugendrappa Anjanapura V. Raghu |
| author_facet | Sharanappa Chapi Gangadhar Babaladimath M. V. Murugendrappa Anjanapura V. Raghu |
| author_sort | Sharanappa Chapi |
| collection | DOAJ |
| description | ABSTRACT In this work, novel tragacanth gum‐graft‐poly(2‐acrylamido‐2‐methylpropanesulfonic acid) (TG‐g‐PAMPS) hydrogel was synthesized via free radical copolymerization of TG, 2‐acrylamido‐2‐methylpropanesulfonic acid by using ammonium peroxodisulfate and N,N‐methylene‐bis‐acrylamide under microwave radiation, resulting in the cross‐linked graft copolymer network. Silver nanoparticles (SNs) were formed and stabilized by the reduction of silver nitrate using tri‐sodium citrate. The TG‐g‐PAMPS gel and its nanocomposite were characterized and confirmed using FTIR, TGA, XRD, SEM, EDS, and TEM techniques. It is observed that the presence of SNs significantly improves the swelling ability of the TG‐g‐PAMPS gel. Degradation studies of both hydrogels were studied using the soil burial method and determining the respective weight loss. The presence of SNs is found to impart significant antibacterial properties to the gel against Pseudomonas aeruginosa and Escherichia coli bacteria. Further, the TG‐g‐PAMPS gel and TG‐g‐PAMPS‐SN were evaluated as matrix materials for the release of the drug (diclofenac sodium) and the effect of SNs on the release was examined. The in‐vitro released data were analyzed using empirical equations to understand the mechanism of release. Among the various models, the released data were well fitted into the Korsmeyer–Peppas equation and the released kinetics followed non‐Fickian diffusion. |
| format | Article |
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| institution | OA Journals |
| issn | 2688-4011 |
| language | English |
| publishDate | 2024-12-01 |
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| series | Nano Select |
| spelling | doaj-art-29f2cc3d7a2a4e78b7516a92f9327fe92025-08-20T02:21:52ZengWiley-VCHNano Select2688-40112024-12-01512n/an/a10.1002/nano.202300200Microwave‐Assisted Tragacanth Gum–Based Grafted Silver Nanocomposite Hydrogel for Sustained Release Formulations of Diclofenac Sodium and Antibacterial AssaySharanappa Chapi0Gangadhar Babaladimath1M. V. Murugendrappa2Anjanapura V. Raghu3Department of Physics B.M.S. College of Engineering Bengaluru Karnataka IndiaPost‐Graduation Department of Chemistry KLE Society's Raja Lakhamagouda Science Institute Belagavi Karnataka IndiaDepartment of Physics B.M.S. College of Engineering Bengaluru Karnataka IndiaDepartment of Basic Sciences Faculty of Engineering and Technology CMR University Bangalore IndiaABSTRACT In this work, novel tragacanth gum‐graft‐poly(2‐acrylamido‐2‐methylpropanesulfonic acid) (TG‐g‐PAMPS) hydrogel was synthesized via free radical copolymerization of TG, 2‐acrylamido‐2‐methylpropanesulfonic acid by using ammonium peroxodisulfate and N,N‐methylene‐bis‐acrylamide under microwave radiation, resulting in the cross‐linked graft copolymer network. Silver nanoparticles (SNs) were formed and stabilized by the reduction of silver nitrate using tri‐sodium citrate. The TG‐g‐PAMPS gel and its nanocomposite were characterized and confirmed using FTIR, TGA, XRD, SEM, EDS, and TEM techniques. It is observed that the presence of SNs significantly improves the swelling ability of the TG‐g‐PAMPS gel. Degradation studies of both hydrogels were studied using the soil burial method and determining the respective weight loss. The presence of SNs is found to impart significant antibacterial properties to the gel against Pseudomonas aeruginosa and Escherichia coli bacteria. Further, the TG‐g‐PAMPS gel and TG‐g‐PAMPS‐SN were evaluated as matrix materials for the release of the drug (diclofenac sodium) and the effect of SNs on the release was examined. The in‐vitro released data were analyzed using empirical equations to understand the mechanism of release. Among the various models, the released data were well fitted into the Korsmeyer–Peppas equation and the released kinetics followed non‐Fickian diffusion.https://doi.org/10.1002/nano.202300200antibacterial activitydrug deliveryKorsmeyer–Peppas modelmicrowave radiationsilver nanoparticlestragacanth gum |
| spellingShingle | Sharanappa Chapi Gangadhar Babaladimath M. V. Murugendrappa Anjanapura V. Raghu Microwave‐Assisted Tragacanth Gum–Based Grafted Silver Nanocomposite Hydrogel for Sustained Release Formulations of Diclofenac Sodium and Antibacterial Assay Nano Select antibacterial activity drug delivery Korsmeyer–Peppas model microwave radiation silver nanoparticles tragacanth gum |
| title | Microwave‐Assisted Tragacanth Gum–Based Grafted Silver Nanocomposite Hydrogel for Sustained Release Formulations of Diclofenac Sodium and Antibacterial Assay |
| title_full | Microwave‐Assisted Tragacanth Gum–Based Grafted Silver Nanocomposite Hydrogel for Sustained Release Formulations of Diclofenac Sodium and Antibacterial Assay |
| title_fullStr | Microwave‐Assisted Tragacanth Gum–Based Grafted Silver Nanocomposite Hydrogel for Sustained Release Formulations of Diclofenac Sodium and Antibacterial Assay |
| title_full_unstemmed | Microwave‐Assisted Tragacanth Gum–Based Grafted Silver Nanocomposite Hydrogel for Sustained Release Formulations of Diclofenac Sodium and Antibacterial Assay |
| title_short | Microwave‐Assisted Tragacanth Gum–Based Grafted Silver Nanocomposite Hydrogel for Sustained Release Formulations of Diclofenac Sodium and Antibacterial Assay |
| title_sort | microwave assisted tragacanth gum based grafted silver nanocomposite hydrogel for sustained release formulations of diclofenac sodium and antibacterial assay |
| topic | antibacterial activity drug delivery Korsmeyer–Peppas model microwave radiation silver nanoparticles tragacanth gum |
| url | https://doi.org/10.1002/nano.202300200 |
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