Carboprost versus Oxytocin as the first-line treatment of primary postpartum haemorrhage (COPE): protocol for a phase IV, double-blind, double-dummy, randomised controlled trial and economic analysis

Carboprost versus Oxytocin as the first-line treatment of primary postpartum haemorrhage (COPE): protocol for a phase IV, double-blind, double-dummy, randomised controlled trial and economic analysis

Introduction Excessive bleeding after childbirth (postpartum haemorrhage, PPH) affects 5% of births and causes 75 000 maternal deaths worldwide annually. It is the leading cause of direct maternal deaths globally and continues to be a major cause of mortality in the UK. Oxytocin is the standard firs...

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Main Authors: Kerry Woolfall, Ben Hardwick, Dimitrios Siassakos, Andrew Shennan, Stephen Robson, Dyfrig A Hughes, Carrol Gamble, Elizabeth Deja, Andrew Weeks, Peter Collins, Jim Thornton, Kirtana Vallabhaneni, Tina Lavender, Gillian Gyte, Helen Hickey, Egle Saviciute, Anna Rosala-Hallas, Efstathia Gkioni, Kim Hinshaw, Catrin Plumpton, Shireen Meher, Annette L Briley, Rachel E Collis, Charlotte Van Netten, Dilly Anumba, Sion Kenyon, Elaine Willis
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/5/e101255.full
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