Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: Pro-inflammatory or anti-inflammatory effect?
A new population of T cells known as Th22 was described for the first time in 2009. These cells are usually identified by the production of IL-22. However, this cytokine is also secreted by other cells such as Th1, Th2, Th17, natural killers, and innate lymphoid cells. Th22 is known as a pro-inflamm...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-08-01
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| Series: | Pediatrics and Neonatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957216303989 |
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| author | Laura Tamasauskiene Brigita Sitkauskiene |
| author_facet | Laura Tamasauskiene Brigita Sitkauskiene |
| author_sort | Laura Tamasauskiene |
| collection | DOAJ |
| description | A new population of T cells known as Th22 was described for the first time in 2009. These cells are usually identified by the production of IL-22. However, this cytokine is also secreted by other cells such as Th1, Th2, Th17, natural killers, and innate lymphoid cells. Th22 is known as a pro-inflammatory agent in allergic skin diseases. Recently, more evidence has emerged showing associations between these cells and other diseases. The role of Th22 in asthma and allergic rhinitis is controversial: some authors suggest that Th22 has a pro-inflammatory effect, while others state that Th22 has anti-inflammatory properties. The aim of this article was to review the role of Th22 and IL-22 in allergic airway diseases based on the most recent literature. This review suggests that Th22 plays a significant role in the pathogenesis of allergic airway diseases and has predominantly anti-inflammatory properties. More studies are needed to clarify the role of Th22 in more detail. Key Words: allergy, asthma, IL-22, rhinitis, Th22 |
| format | Article |
| id | doaj-art-29e2e481ffe343f791f7aa886466a595 |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-29e2e481ffe343f791f7aa886466a5952025-08-20T02:10:57ZengElsevierPediatrics and Neonatology1875-95722018-08-0159433934410.1016/j.pedneo.2017.11.020Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: Pro-inflammatory or anti-inflammatory effect?Laura Tamasauskiene0Brigita Sitkauskiene1Corresponding author. Department of Immunology and Allergology, Lithuanian University of Health Sciences, Eiveniu str. 2, Kaunas, LT-50161, Lithuania.; Department of Immunology and Allergology, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Immunology and Allergology, Lithuanian University of Health Sciences, Kaunas, LithuaniaA new population of T cells known as Th22 was described for the first time in 2009. These cells are usually identified by the production of IL-22. However, this cytokine is also secreted by other cells such as Th1, Th2, Th17, natural killers, and innate lymphoid cells. Th22 is known as a pro-inflammatory agent in allergic skin diseases. Recently, more evidence has emerged showing associations between these cells and other diseases. The role of Th22 in asthma and allergic rhinitis is controversial: some authors suggest that Th22 has a pro-inflammatory effect, while others state that Th22 has anti-inflammatory properties. The aim of this article was to review the role of Th22 and IL-22 in allergic airway diseases based on the most recent literature. This review suggests that Th22 plays a significant role in the pathogenesis of allergic airway diseases and has predominantly anti-inflammatory properties. More studies are needed to clarify the role of Th22 in more detail. Key Words: allergy, asthma, IL-22, rhinitis, Th22http://www.sciencedirect.com/science/article/pii/S1875957216303989 |
| spellingShingle | Laura Tamasauskiene Brigita Sitkauskiene Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: Pro-inflammatory or anti-inflammatory effect? Pediatrics and Neonatology |
| title | Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: Pro-inflammatory or anti-inflammatory effect? |
| title_full | Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: Pro-inflammatory or anti-inflammatory effect? |
| title_fullStr | Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: Pro-inflammatory or anti-inflammatory effect? |
| title_full_unstemmed | Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: Pro-inflammatory or anti-inflammatory effect? |
| title_short | Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: Pro-inflammatory or anti-inflammatory effect? |
| title_sort | role of th22 and il 22 in pathogenesis of allergic airway diseases pro inflammatory or anti inflammatory effect |
| url | http://www.sciencedirect.com/science/article/pii/S1875957216303989 |
| work_keys_str_mv | AT lauratamasauskiene roleofth22andil22inpathogenesisofallergicairwaydiseasesproinflammatoryorantiinflammatoryeffect AT brigitasitkauskiene roleofth22andil22inpathogenesisofallergicairwaydiseasesproinflammatoryorantiinflammatoryeffect |