Brain Activation Pattern Caused by Soft Rehabilitation Glove and Virtual Reality Scenes: A Pilot fNIRS Study
Clinical studies have proved significant improvements in hand motor function in stroke patients when assisted by robotic devices. However, there were few studies on neural activity changes in the brain during execution. This study aimed to investigate the brain activation pattern caused by soft reha...
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| Language: | English |
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IEEE
2024-01-01
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| Series: | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
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| Online Access: | https://ieeexplore.ieee.org/document/10721199/ |
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| author | Pengju Liu Xinyi Yang Fenglin Han Guangshuai Peng Qiao Li Liping Huang Lizhen Wang Yubo Fan |
| author_facet | Pengju Liu Xinyi Yang Fenglin Han Guangshuai Peng Qiao Li Liping Huang Lizhen Wang Yubo Fan |
| author_sort | Pengju Liu |
| collection | DOAJ |
| description | Clinical studies have proved significant improvements in hand motor function in stroke patients when assisted by robotic devices. However, there were few studies on neural activity changes in the brain during execution. This study aimed to investigate the brain activation pattern caused by soft rehabilitation glove and virtual reality scenes. Twenty healthy subjects and twenty stroke patients were recruited to complete three controlled trials: grasping passively with robotic glove assistance (RA), watching grasping movement video in virtual reality (VR), and the joint use of robotic glove and virtual reality (VRA). Neural activity in the prefrontal cortex, motor cortex and occipital lobe was synchronously collected by the functional near-infrared spectroscopy (fNIRS) device. Activation level and functional connectivity of these brain regions were subsequently calculated and statistically analyzed. For both groups, the VR and VRA tasks induced activation of larger cortical areas. Stroke group had higher average cortical activation in all three tasks compared to healthy group, especially in the prefrontal cortex (<inline-formula> <tex-math notation="LaTeX">${P} \lt 0.05$ </tex-math></inline-formula>). Functional connectivity was weaker in the stroke group than in the healthy group across most regions, but was significantly stronger across some regions of the right hemisphere. These findings suggest significant differences in activation patterns across three tasks. In addition, multi-sensory stimulation can promote functional communication between more brain regions in patients. It has potential for neuromodulation in rehabilitation training by setting up different sensory stimulation modalities. |
| format | Article |
| id | doaj-art-29dbb41f3170424780ef6fd09d14f801 |
| institution | DOAJ |
| issn | 1534-4320 1558-0210 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | IEEE |
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| series | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| spelling | doaj-art-29dbb41f3170424780ef6fd09d14f8012025-08-20T03:13:42ZengIEEEIEEE Transactions on Neural Systems and Rehabilitation Engineering1534-43201558-02102024-01-01323848385710.1109/TNSRE.2024.348247010721199Brain Activation Pattern Caused by Soft Rehabilitation Glove and Virtual Reality Scenes: A Pilot fNIRS StudyPengju Liu0https://orcid.org/0000-0002-6171-9612Xinyi Yang1Fenglin Han2Guangshuai Peng3Qiao Li4Liping Huang5Lizhen Wang6https://orcid.org/0000-0002-9658-659XYubo Fan7https://orcid.org/0000-0002-3480-4395Key Laboratory for Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaKey Laboratory for Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaKey Laboratory for Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaKey Laboratory for Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaSchool of Engineering Medicine, Beihang University, Beijing, ChinaDepartment of Rehabilitation Medicine, The First Medical Center, Chinese PLA General Hospital, Haidian, Beijing, ChinaKey Laboratory for Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaKey Laboratory for Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaClinical studies have proved significant improvements in hand motor function in stroke patients when assisted by robotic devices. However, there were few studies on neural activity changes in the brain during execution. This study aimed to investigate the brain activation pattern caused by soft rehabilitation glove and virtual reality scenes. Twenty healthy subjects and twenty stroke patients were recruited to complete three controlled trials: grasping passively with robotic glove assistance (RA), watching grasping movement video in virtual reality (VR), and the joint use of robotic glove and virtual reality (VRA). Neural activity in the prefrontal cortex, motor cortex and occipital lobe was synchronously collected by the functional near-infrared spectroscopy (fNIRS) device. Activation level and functional connectivity of these brain regions were subsequently calculated and statistically analyzed. For both groups, the VR and VRA tasks induced activation of larger cortical areas. Stroke group had higher average cortical activation in all three tasks compared to healthy group, especially in the prefrontal cortex (<inline-formula> <tex-math notation="LaTeX">${P} \lt 0.05$ </tex-math></inline-formula>). Functional connectivity was weaker in the stroke group than in the healthy group across most regions, but was significantly stronger across some regions of the right hemisphere. These findings suggest significant differences in activation patterns across three tasks. In addition, multi-sensory stimulation can promote functional communication between more brain regions in patients. It has potential for neuromodulation in rehabilitation training by setting up different sensory stimulation modalities.https://ieeexplore.ieee.org/document/10721199/Strokecortical activationwearable rehabilitation devicevirtual realityfNIRS |
| spellingShingle | Pengju Liu Xinyi Yang Fenglin Han Guangshuai Peng Qiao Li Liping Huang Lizhen Wang Yubo Fan Brain Activation Pattern Caused by Soft Rehabilitation Glove and Virtual Reality Scenes: A Pilot fNIRS Study IEEE Transactions on Neural Systems and Rehabilitation Engineering Stroke cortical activation wearable rehabilitation device virtual reality fNIRS |
| title | Brain Activation Pattern Caused by Soft Rehabilitation Glove and Virtual Reality Scenes: A Pilot fNIRS Study |
| title_full | Brain Activation Pattern Caused by Soft Rehabilitation Glove and Virtual Reality Scenes: A Pilot fNIRS Study |
| title_fullStr | Brain Activation Pattern Caused by Soft Rehabilitation Glove and Virtual Reality Scenes: A Pilot fNIRS Study |
| title_full_unstemmed | Brain Activation Pattern Caused by Soft Rehabilitation Glove and Virtual Reality Scenes: A Pilot fNIRS Study |
| title_short | Brain Activation Pattern Caused by Soft Rehabilitation Glove and Virtual Reality Scenes: A Pilot fNIRS Study |
| title_sort | brain activation pattern caused by soft rehabilitation glove and virtual reality scenes a pilot fnirs study |
| topic | Stroke cortical activation wearable rehabilitation device virtual reality fNIRS |
| url | https://ieeexplore.ieee.org/document/10721199/ |
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