MVA-based SARS-CoV-2 vaccine candidates encoding different spike protein conformations induce distinct early transcriptional responses which may impact subsequent adaptive immunity

MVA-based SARS-CoV-2 vaccine candidates encoding different spike protein conformations induce distinct early transcriptional responses which may impact subsequent adaptive immunity

IntroductionVaccine platforms such as viral vectors and mRNA can accelerate vaccine development in response to newly emerging pathogens, as demonstrated during the COVID-19 pandemic. However, the differential effects of platform and antigen insert on vaccine immunogenicity remain incompletely unders...

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Bibliographic Details
Main Authors: Ilka Grewe, Monika Friedrich, Marie-Louise Dieck, Michael Spohn, My Linh Ly, Verena Krähling, Leonie Mayer, Sibylle C. Mellinghoff, Monika Rottstegge, Rebekka Kraemer, Asisa Volz, Stephan Becker, Anahita Fathi, Christine Dahlke, Leonie M. Weskamm, Marylyn M. Addo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
COVID-19
modified vaccinia virus Ankara
systems vaccinology
spike protein
transcriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500615/full
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