TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32-mediated ubiquitination

TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32-mediated ubiquitination

Abstract Background Bone metastasis is a principal cause of mortality in patients with prostate cancer (PCa). Increasing evidence indicates that high expression of stromal interaction molecule 1 (STIM1)-mediated store-operated calcium entry (SOCE) significantly activates the calcium (Ca2+) signaling...

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Main Authors: Qianghua Zhou, Xu Chen, Kai Yao, Yangjie Zhang, Haixia He, Hao Huang, Hao Chen, Shengmeng Peng, Ming Huang, Liang Cheng, Qiang Zhang, Ruihui Xie, Kaiwen Li, Tianxin Lin, Hai Huang
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Prostate cancer
Bone metastasis
STIM1
TSPAN18
TRIM32
Online Access:https://doi.org/10.1186/s13046-023-02764-4
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