Optimal dose and type of exercise improve walking velocity in adults with Parkinson’s disease: a systematic review and Bayesian network meta-analysis
Abstract To examine the dose–response relationship between specific types of exercise for improving walking velocity in Parkinson’s disease (PD). This systematic review and network meta-analysis included searches of PubMed, Medline, Embase, PsycINFO, Cochrane Library, and Web of Science were searche...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-85456-7 |
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| author | Shaoqing Xie Yuan Yuan Junyu Wang Ying Bai Tao Wang Bopeng Qiu Yong Yang Shu-Cheng Lin |
| author_facet | Shaoqing Xie Yuan Yuan Junyu Wang Ying Bai Tao Wang Bopeng Qiu Yong Yang Shu-Cheng Lin |
| author_sort | Shaoqing Xie |
| collection | DOAJ |
| description | Abstract To examine the dose–response relationship between specific types of exercise for improving walking velocity in Parkinson’s disease (PD). This systematic review and network meta-analysis included searches of PubMed, Medline, Embase, PsycINFO, Cochrane Library, and Web of Science were searched from inception until February 18th, 2024. Data analysis was performed using R software with the MBNMA and RJAGS packages. Outcome indicators were measured as mean standard deviation (SMD) along with 95% confidence intervals (95% CrI). The network’s risk of bias was independently evaluated by two reviewers employing the ROB2 tool. Our review encompassed 54 studies with 2,828 PD patients, examining the dose–response effects of different exercises on walking velocity. Aerobic Exercise (AE) demonstrated the greatest improvement at an optimal dose of 1,400 METs-min/week (SMD:1.215, 95% Crl: 0.113 to 2.306). Both Multicomponent Exercise (Mul) (SMD: 1.202, 95% Crl: 0.193 to 2.231) and Sensory Exercise (SE) (SMD: 0.649, 95% Crl: 0.139 to 1.183) showed optimal outcomes at a dose of 1,000 METs-min/week. Resistance Training (RT) was most effective at 750 METs-min/week (SMD:0.778, 95% Crl: 0.062 to 1.549), while Mind–Body Exercise (MBE) yielded significant improvements at a lower optimal dose of 500 METs-min/week (SMD: 0.580, 95% Crl: 0.218 to 1.137), offering valuable insights for exercise prescription in PD management. Various types of exercise showed specific optimal benefits at corresponding doses, among which AE was the most effective in improving the walking speed of PD patients at 1,400 Mets*min/week. Trial registration: PROSPERO (CRD42024506919). |
| format | Article |
| id | doaj-art-29d59ca5958f49fd8ff90a08d5032eee |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-29d59ca5958f49fd8ff90a08d5032eee2025-01-19T12:24:12ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-025-85456-7Optimal dose and type of exercise improve walking velocity in adults with Parkinson’s disease: a systematic review and Bayesian network meta-analysisShaoqing Xie0Yuan Yuan1Junyu Wang2Ying Bai3Tao Wang4Bopeng Qiu5Yong Yang6Shu-Cheng Lin7School of Physical Education and Sport, West Anhui UniversityDepartment of Physical Education, Kunsan National UniversitySchool of Exercise and Health, Shanghai University of SportDepartment of Physical Education, Kunsan National UniversitySchool of Physical Education and Institute of Sports Biology, Shaanxi Normal UniversitySchool of Strength and Conditioning Training, Beijing Sport UniversityLaboratory of Kinesiology and Rehabilitation, School of Physical Education and Sport, Chaohu UniversitySchool of Gerontology and Long-Term Care, Taipei Medical University, Taipei City 110, Taiwan (R.O.C.)Abstract To examine the dose–response relationship between specific types of exercise for improving walking velocity in Parkinson’s disease (PD). This systematic review and network meta-analysis included searches of PubMed, Medline, Embase, PsycINFO, Cochrane Library, and Web of Science were searched from inception until February 18th, 2024. Data analysis was performed using R software with the MBNMA and RJAGS packages. Outcome indicators were measured as mean standard deviation (SMD) along with 95% confidence intervals (95% CrI). The network’s risk of bias was independently evaluated by two reviewers employing the ROB2 tool. Our review encompassed 54 studies with 2,828 PD patients, examining the dose–response effects of different exercises on walking velocity. Aerobic Exercise (AE) demonstrated the greatest improvement at an optimal dose of 1,400 METs-min/week (SMD:1.215, 95% Crl: 0.113 to 2.306). Both Multicomponent Exercise (Mul) (SMD: 1.202, 95% Crl: 0.193 to 2.231) and Sensory Exercise (SE) (SMD: 0.649, 95% Crl: 0.139 to 1.183) showed optimal outcomes at a dose of 1,000 METs-min/week. Resistance Training (RT) was most effective at 750 METs-min/week (SMD:0.778, 95% Crl: 0.062 to 1.549), while Mind–Body Exercise (MBE) yielded significant improvements at a lower optimal dose of 500 METs-min/week (SMD: 0.580, 95% Crl: 0.218 to 1.137), offering valuable insights for exercise prescription in PD management. Various types of exercise showed specific optimal benefits at corresponding doses, among which AE was the most effective in improving the walking speed of PD patients at 1,400 Mets*min/week. Trial registration: PROSPERO (CRD42024506919).https://doi.org/10.1038/s41598-025-85456-7Parkinson’s diseaseExerciseWalking velocityDose–responseRCTsBayesian network meta-analysis |
| spellingShingle | Shaoqing Xie Yuan Yuan Junyu Wang Ying Bai Tao Wang Bopeng Qiu Yong Yang Shu-Cheng Lin Optimal dose and type of exercise improve walking velocity in adults with Parkinson’s disease: a systematic review and Bayesian network meta-analysis Scientific Reports Parkinson’s disease Exercise Walking velocity Dose–response RCTs Bayesian network meta-analysis |
| title | Optimal dose and type of exercise improve walking velocity in adults with Parkinson’s disease: a systematic review and Bayesian network meta-analysis |
| title_full | Optimal dose and type of exercise improve walking velocity in adults with Parkinson’s disease: a systematic review and Bayesian network meta-analysis |
| title_fullStr | Optimal dose and type of exercise improve walking velocity in adults with Parkinson’s disease: a systematic review and Bayesian network meta-analysis |
| title_full_unstemmed | Optimal dose and type of exercise improve walking velocity in adults with Parkinson’s disease: a systematic review and Bayesian network meta-analysis |
| title_short | Optimal dose and type of exercise improve walking velocity in adults with Parkinson’s disease: a systematic review and Bayesian network meta-analysis |
| title_sort | optimal dose and type of exercise improve walking velocity in adults with parkinson s disease a systematic review and bayesian network meta analysis |
| topic | Parkinson’s disease Exercise Walking velocity Dose–response RCTs Bayesian network meta-analysis |
| url | https://doi.org/10.1038/s41598-025-85456-7 |
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