Prunellate A: An Unprecedented Lignan Lactone with a 6/7/6/5-Fused Tetracycle Skeleton by C‑2–C-2′ and C‑7–C-8′ Linkage from the Chinese Medicinal Plant Prunella vulgaris Inhibiting the Activation of Hepatic Stellate Cells by Targeting FXR
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2025-03-01
|
| Series: | ACS Omega |
| Online Access: | https://doi.org/10.1021/acsomega.4c11609 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850275611641118720 |
|---|---|
| author | Xiuqin Zheng Yi Zhang Qian Zhang Jia-rui Jiang Zhu-zhen Han Li-hua Gu Li-li Ding Rui Wang Li Yang Zheng-tao Wang |
| author_facet | Xiuqin Zheng Yi Zhang Qian Zhang Jia-rui Jiang Zhu-zhen Han Li-hua Gu Li-li Ding Rui Wang Li Yang Zheng-tao Wang |
| author_sort | Xiuqin Zheng |
| collection | DOAJ |
| format | Article |
| id | doaj-art-29d542cf1ff94a62b73e2bb2e627c586 |
| institution | OA Journals |
| issn | 2470-1343 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | ACS Omega |
| spelling | doaj-art-29d542cf1ff94a62b73e2bb2e627c5862025-08-20T01:50:41ZengAmerican Chemical SocietyACS Omega2470-13432025-03-011012124251243110.1021/acsomega.4c11609Prunellate A: An Unprecedented Lignan Lactone with a 6/7/6/5-Fused Tetracycle Skeleton by C‑2–C-2′ and C‑7–C-8′ Linkage from the Chinese Medicinal Plant Prunella vulgaris Inhibiting the Activation of Hepatic Stellate Cells by Targeting FXRXiuqin Zheng0Yi Zhang1Qian Zhang2Jia-rui Jiang3Zhu-zhen Han4Li-hua Gu5Li-li Ding6Rui Wang7Li Yang8Zheng-tao Wang9School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. ChinaInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. ChinaInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. ChinaInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. ChinaInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. ChinaInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. ChinaInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. ChinaInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. ChinaInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. Chinahttps://doi.org/10.1021/acsomega.4c11609 |
| spellingShingle | Xiuqin Zheng Yi Zhang Qian Zhang Jia-rui Jiang Zhu-zhen Han Li-hua Gu Li-li Ding Rui Wang Li Yang Zheng-tao Wang Prunellate A: An Unprecedented Lignan Lactone with a 6/7/6/5-Fused Tetracycle Skeleton by C‑2–C-2′ and C‑7–C-8′ Linkage from the Chinese Medicinal Plant Prunella vulgaris Inhibiting the Activation of Hepatic Stellate Cells by Targeting FXR ACS Omega |
| title | Prunellate A: An Unprecedented Lignan Lactone with a 6/7/6/5-Fused Tetracycle Skeleton by C‑2–C-2′ and C‑7–C-8′ Linkage from the Chinese Medicinal Plant Prunella vulgaris Inhibiting the Activation of Hepatic Stellate Cells by Targeting FXR |
| title_full | Prunellate A: An Unprecedented Lignan Lactone with a 6/7/6/5-Fused Tetracycle Skeleton by C‑2–C-2′ and C‑7–C-8′ Linkage from the Chinese Medicinal Plant Prunella vulgaris Inhibiting the Activation of Hepatic Stellate Cells by Targeting FXR |
| title_fullStr | Prunellate A: An Unprecedented Lignan Lactone with a 6/7/6/5-Fused Tetracycle Skeleton by C‑2–C-2′ and C‑7–C-8′ Linkage from the Chinese Medicinal Plant Prunella vulgaris Inhibiting the Activation of Hepatic Stellate Cells by Targeting FXR |
| title_full_unstemmed | Prunellate A: An Unprecedented Lignan Lactone with a 6/7/6/5-Fused Tetracycle Skeleton by C‑2–C-2′ and C‑7–C-8′ Linkage from the Chinese Medicinal Plant Prunella vulgaris Inhibiting the Activation of Hepatic Stellate Cells by Targeting FXR |
| title_short | Prunellate A: An Unprecedented Lignan Lactone with a 6/7/6/5-Fused Tetracycle Skeleton by C‑2–C-2′ and C‑7–C-8′ Linkage from the Chinese Medicinal Plant Prunella vulgaris Inhibiting the Activation of Hepatic Stellate Cells by Targeting FXR |
| title_sort | prunellate a an unprecedented lignan lactone with a 6 7 6 5 fused tetracycle skeleton by c 2 c 2 and c 7 c 8 linkage from the chinese medicinal plant prunella vulgaris inhibiting the activation of hepatic stellate cells by targeting fxr |
| url | https://doi.org/10.1021/acsomega.4c11609 |
| work_keys_str_mv | AT xiuqinzheng prunellateaanunprecedentedlignanlactonewitha6765fusedtetracycleskeletonbyc2c2andc7c8linkagefromthechinesemedicinalplantprunellavulgarisinhibitingtheactivationofhepaticstellatecellsbytargetingfxr AT yizhang prunellateaanunprecedentedlignanlactonewitha6765fusedtetracycleskeletonbyc2c2andc7c8linkagefromthechinesemedicinalplantprunellavulgarisinhibitingtheactivationofhepaticstellatecellsbytargetingfxr AT qianzhang prunellateaanunprecedentedlignanlactonewitha6765fusedtetracycleskeletonbyc2c2andc7c8linkagefromthechinesemedicinalplantprunellavulgarisinhibitingtheactivationofhepaticstellatecellsbytargetingfxr AT jiaruijiang prunellateaanunprecedentedlignanlactonewitha6765fusedtetracycleskeletonbyc2c2andc7c8linkagefromthechinesemedicinalplantprunellavulgarisinhibitingtheactivationofhepaticstellatecellsbytargetingfxr AT zhuzhenhan prunellateaanunprecedentedlignanlactonewitha6765fusedtetracycleskeletonbyc2c2andc7c8linkagefromthechinesemedicinalplantprunellavulgarisinhibitingtheactivationofhepaticstellatecellsbytargetingfxr AT lihuagu prunellateaanunprecedentedlignanlactonewitha6765fusedtetracycleskeletonbyc2c2andc7c8linkagefromthechinesemedicinalplantprunellavulgarisinhibitingtheactivationofhepaticstellatecellsbytargetingfxr AT liliding prunellateaanunprecedentedlignanlactonewitha6765fusedtetracycleskeletonbyc2c2andc7c8linkagefromthechinesemedicinalplantprunellavulgarisinhibitingtheactivationofhepaticstellatecellsbytargetingfxr AT ruiwang prunellateaanunprecedentedlignanlactonewitha6765fusedtetracycleskeletonbyc2c2andc7c8linkagefromthechinesemedicinalplantprunellavulgarisinhibitingtheactivationofhepaticstellatecellsbytargetingfxr AT liyang prunellateaanunprecedentedlignanlactonewitha6765fusedtetracycleskeletonbyc2c2andc7c8linkagefromthechinesemedicinalplantprunellavulgarisinhibitingtheactivationofhepaticstellatecellsbytargetingfxr AT zhengtaowang prunellateaanunprecedentedlignanlactonewitha6765fusedtetracycleskeletonbyc2c2andc7c8linkagefromthechinesemedicinalplantprunellavulgarisinhibitingtheactivationofhepaticstellatecellsbytargetingfxr |